Simulation of Cardiac Ischemia and Arrhythmias - PDF document

Simulation of Cardiac Ischemia and Arrhythmias !"#$%&'()"* +&,*-".&/'01&,$!)/)&,'2$&3*$4,&-3-35$63/7808)$9+:!46; +"<=,)2)3/-.)$>,,2?82<-&$!)/)&,'2$&3*$ %>3&5)<)38$+)38),$9+>!%>; CVRTI

CARMA Heart Disease is a Killer

Simulation of Ischemia Ischemia

Coronary Supply versus Demand Supply Demand Coronary Supply versus Demand Supply Demand

Coronary Supply versus Demand Ischemia ! Supply Demand Coronary Supply versus Demand Supply Demand

Coronary Supply versus Demand Ischemia ! Supply Demand Heart Attacks and the ECG Continuous monitoring: ! 30-50% error rate ! Lead locations unclear, suboptimal ! Tracks changes dynamically Stress testing ! Low sensitivity/specificity ! Thresholds variable ! Tracks changes during stress

Experiments and Simulations Ischemic Zone LV RV Blood Pump Shome et al. IEEE EMBS, 2004 Hopenfeld et al. JCE, 15:1200, 2004 Simulation of Ischemia Intracellular Extracellular V m V i , g il , g it V e , g el , g et @-*"<&-3$>==,"&'2 A<#)*$6/'2)<-&

Model Making B46 :&/'01&80,) The Tools

Comparing Models to Experiments A 40% Transmural 70% Transmural 90% Transmural #$%&'()% *+,' -" !" B !"#$%&$'()$*)+',)-./0)12314550)4556) The Goal

Simulation of Atrial Arrhythmias Fibrosis Linked to AF

Fibrosis Linked to AF Modeling Approach v e , g e Extracellular I m Intracellular v i , g i

Model Construction Initial Results