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Serum Uric Acid, Lipid Profile and Atherogenic Index of Plasma in Dipper and Non-dipper Normotensive Subjects

Wai Wai Phyo Nwe, Aye Mya Mya Thwin, Mya Mya Thwin Department of Physiology, University of Medicine 2, Yangon

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Background information

• Blood pressure is under circadian diurnal control and normally declines during sleep,

compared to daytime.

• Individuals with a fall in arterial blood pressure of 10% or more at night are dippers,

whereas those without a fall in blood pressure at night are non-dippers (O’ Brien et al., 1988).

• The presence of non-dipping hypertension, elevated serum uric acid level,

dyslipidemia and higher AIP values are cardiovascular risk factors.

• By determining and comparing serum uric acid, fasting lipid profile and AIP in

dipper and non-dipper normotensive subjects, cardiovascular risk factors could be monitored in normotensive subjects.

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Methods

• A total of 64 apparently healthy normotensive male and female subjects,

(age between 30-55 years )with BMI less than 25kg/m2 were involved in this study.

• They were divided into dippers and non-dippers by using

24-hour ambulatory blood pressure monitoring device (Spacelabs-90207).

• Fasting lipid profile and uric acid were determined and AIP values were

calculated by using formula (log[TG/HDL]).

• This study was done from April 2016 to April 2017.

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Results

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Figure 1. Comparison of serum uric acid level in normotensive dippers and non- dippers Figure 2. Comparison of serum triglyceride level in normotensive dippers and non-dippers

p <0.001 p < 0.05pp< 0.05

Results

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P0p < 0.001

Figure 3. Comparison of atherogenic index of plasma (AIP) value in normotensive dippers and non-dippers

Results

• The median (interquartile range) of serum uric acid in the dipper group was

5.08 (4.12-5.66) mg/dL and the non-dipper group was 5.27 (4.63-6.33) mg/dL .

• The median (interquartile range) of triglyceride in the dipper group was

91.89 (72.36-122.3) mg/dL and in the non-dipper group was 142.91 (113.12-242.42) mg/dL.

• The median (interquartile range) of AIP was 0.24 (0.05-0.38) in the dipper

group and 0.48 (0.32-0.67) in the non-dipper group.

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Results

• The median (interquartile range) of serum uric acid, triglyceride and AIP

values in non-dipper group were significantly higher than that of dipper group (p < 0.05).

• The median (interquartile range) of total cholesterol and LDL cholesterol

in non-dipper group were higher than that of dipper group, but statistically significant difference was not seen (p > 0.05).

• The median (interquartile range) of HDL in non-dipper group was lower

than that of dipper group, statistically significant difference was not seen (p > 0.05).

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Conclusion

• In the present study, serum uric acid, triglyceride, total cholesterol and AIP

values, which were used as risk factors for cardiovascular disease, were increased in non-dipper group.

• Thus,

it would be concluded that non-dipper group had higher cardiovascular risk than dipper group even in normotensive healthy subjects.

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