Serum Uric Acid, Lipid Profile and Atherogenic Index of Plasma in Dipper and Non-dipper Normotensive Subjects Wai Wai Phyo Nwe, Aye Mya Mya Thwin, Mya Mya Thwin Department of Physiology, University of Medicine 2, Yangon Wai Wai Phyo Nwe JCMS 2017 1
Background information Blood pressure is under circadian diurnal control and normally declines during sleep, • compared to daytime. Individuals with a fall in arterial blood pressure of 10% or more at night are dippers, • whereas those without a fall in blood pressure at night are non-dippers (O’ Brien et al ., 1988). The presence of non-dipping hypertension, elevated serum uric acid level, • dyslipidemia and higher AIP values are cardiovascular risk factors. By determining and comparing serum uric acid, fasting lipid profile and AIP in • dipper and non-dipper normotensive subjects, cardiovascular risk factors could be monitored in normotensive subjects. Wai Wai Phyo Nwe JCMS 2017 2
Methods A total of 64 apparently healthy normotensive male and female subjects, • (age between 30-55 years )with BMI less than 25kg/m 2 were involved in this study. They were divided into dippers and non-dippers by using 24-hour • ambulatory blood pressure monitoring device (Spacelabs-90207). Fasting lipid profile and uric acid were determined and AIP values were • calculated by using formula (log[TG/HDL]). This study was done from April 2016 to April 2017. • Wai Wai Phyo Nwe JCMS 2017 3
Results p < 0.05pp< p <0.001 0.05 Figure 1. Comparison of serum uric acid Figure 2. Comparison of serum triglyceride level in normotensive dippers and non- level in normotensive dippers and non-dippers dippers Wai Wai Phyo Nwe JCMS 2017 4
Results P0p < 0.001 Figure 3. Comparison of atherogenic index of plasma (AIP) value in normotensive dippers and non-dippers Wai Wai Phyo Nwe 5 JCMS 2017
Results The median (interquartile range) of serum uric acid in the dipper group was • 5.08 (4.12-5.66) mg/dL and the non-dipper group was 5.27 (4.63-6.33) mg/dL . The median (interquartile range) of triglyceride in the dipper group was • 91.89 (72.36-122.3) mg/dL and in the non-dipper group was 142.91 (113.12-242.42) mg/dL. The median (interquartile range) of AIP was 0.24 (0.05-0.38) in the dipper • group and 0.48 (0.32-0.67) in the non-dipper group. Wai Wai Phyo Nwe JCMS 2017 6
Results The median (interquartile range) of serum uric acid, triglyceride and AIP • values in non-dipper group were significantly higher than that of dipper group (p < 0.05). The median (interquartile range) of total cholesterol and LDL cholesterol • in non-dipper group were higher than that of dipper group, but statistically significant difference was not seen (p > 0.05). The median (interquartile range) of HDL in non-dipper group was lower • than that of dipper group, statistically significant difference was not seen (p > 0.05). Wai Wai Phyo Nwe JCMS 2017 7
Conclusion In the present study, serum uric acid, triglyceride, total cholesterol and AIP • values, which were used as risk factors for cardiovascular disease, were increased in non-dipper group. Thus, it would be concluded that non-dipper group had higher • cardiovascular risk than dipper group even in normotensive healthy subjects. Wai Wai Phyo Nwe JCMS 2017 8
Wai Wai Phyo Nwe JCMS 2017 9
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