Selection and haplotypes EHH statistics Anders Albrechtsen - - PowerPoint PPT Presentation

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Nov 25, 2022 408 likes •669 views

Selection and haplotypes EHH statistics Anders Albrechtsen Haplotypes Signature of selection Mutation enters the population Mutation increases in frequency due to positive selection Increases LD Affects the variability

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Selection and haplotypes EHH statistics

Anders Albrechtsen

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Haplotypes

Signature of selection

Mutation enters the

population

Mutation increases in

frequency due to positive selection

Increases LD
Affects the variability
Increases haplotype

similarity

Increases differences with
ther populations in the

whole region

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Haplotypes

EHH - Extended Haplotype Homozygosity

What is EHH? Extended haplotype homozygosity (EHH): EHH at distance x from the core region is the probability that two randomly chosen chromosomes carry a tested core haplotype are homozygous at all SNPs for the entire interval from the core region to the distance x .

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Haplotypes

slides stolen from Matteo Fumagalli

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

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Haplotypes

iHs

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Haplotypes

iHs

ften |iHs| is used

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Haplotypes

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Haplotypes

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Haplotypes

Exercises

Let see how the haplotype methods works on famous examples of human adaptation (LCT). go to http://popgen.dk/albrecht/BAG2018/web/

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Haplotypes