Sea Lane Human Antibody Libraries Sea Lane Human Antibody Libraries ConCIRT™ and EnCORE � Largest, highest quality known synthetic library � Built-in optimization technology to improve candidates Rondo � Disease targeted and therapeutically annotated collection � Proprietary, addressable, barcoded sub-library system Ensemble � Leverages attributes of ConCIRT and Rondo to provide additional unique solutions from a semisynthetic repertoire www.sealanebio.com Sea Lane Biotechnologies – Proprietary
ConCIRT Libraries are Productive Against ConCIRT Libraries are Productive Against Structurally Diverse Targets Structurally Diverse Targets Protein Protein Class Structural type Structural type Class 3- Ig-like domain alpha-helical cytokine 7-Ig-like domain Growth Factor Receptor Cys-rich domain Cysteine knot Cytokine Sema and Ig-like domain dimeric cytokine Receptor Ig-like superfamily IL-1 superfamily Death Receptor TNF Receptor-like TNF-like Cysteine knot Cysteine knot phospho/sulfated EGF-like Growth Factor Ligand protein Kringle and Serine Protease- TNF superfamily like domains Costimulatory Ig-like superfamily Chemokine Chemokine Molecule www.sealanebio.com Sea Lane Biotechnologies – Proprietary
ConCIRT Antibody Libraries Yield Industry Competitive High Affinity Hits Unoptimized ConCIRT antibody EnCORE optimization rapidly hits have good affinities yields greatly improved affinities 70 60 % Fabs tested 50 “variants” 40 Improved 30 binders “parent” 20 10 -4 -2 0 2 4 Log nM >1 μ M <1 nM 1-9.9 10-99 100-999 nM nM nM www.sealanebio.com Sea Lane Biotechnologies – Proprietary
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