Sea Lane Human Antibody Libraries Sea Lane Human Antibody Libraries - - PowerPoint PPT Presentation
Sea Lane Human Antibody Libraries Sea Lane Human Antibody Libraries ConCIRT and EnCORE Largest, highest quality known synthetic library Built-in optimization technology to improve candidates Rondo Disease targeted and
www.sealanebio.com Sea Lane Biotechnologies – Proprietary
Largest, highest quality known synthetic library Built-in optimization technology to improve candidates
Disease targeted and therapeutically annotated collection Proprietary, addressable, barcoded sub-library system
Leverages attributes of ConCIRT and Rondo to provide
www.sealanebio.com Sea Lane Biotechnologies – Proprietary
Protein Class Structural type Protein Class Structural type
Growth Factor Receptor 3- Ig-like domain Cytokine alpha-helical cytokine 7-Ig-like domain Cys-rich domain Cysteine knot Sema and Ig-like domain dimeric cytokine Receptor Ig-like superfamily IL-1 superfamily Death Receptor TNF Receptor-like TNF-like Growth Factor Cysteine knot Ligand Cysteine knot EGF-like phospho/sulfated protein Kringle and Serine Protease- like domains TNF superfamily Costimulatory Molecule Ig-like superfamily Chemokine Chemokine
www.sealanebio.com Sea Lane Biotechnologies – Proprietary
<1 nM 1-9.9 nM 100-999 nM 10-99 nM >1 μM
% Fabs tested
10 20 30 40 50 60 70
2 4
Log nM
“variants” “parent”
Improved binders