SCEPTER-III Clinical Trials to Evaluate Patient-Centered Outcomes - PowerPoint PPT Presentation

SCEPTER-III Clinical Trials to Evaluate Patient-Centered Outcomes of Sedation in Mechanically Ventilated Patients in the Adult ICU March 28-29, 2019 Washington, DC

Pre-clinical testing Compound Discovery Phase 4 post marketing clinical trials Phase 1 -3 clinical trials FDA Approval

Practicing Clinician Pharma FDA Data Clinical Collection Trial Outcomes Design (GCP) Academic Clinical Public Health Care Systems Researcher

Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research (SCEPTER) • Two systematic reviews on Procedural Sedation (adult and pediatric) published • Two consensus recommendations published on Procedural Sedation (Efficacy and Safety) • Consensus conference on sedation for Adult ICU patients in March • Future conference on sedation for Pediatric ICU patients

https://www.openanesthesia.org/article-of-the-month/

Safe Equitable Timely Healthcare Quality Domains Patient Efficient centered Effective

Clinician Patient • Rapid recovery & D/C • Comfortable • Ease of sedation • Optimal procedure • No anxiety • Consistent sedation outcome • No unpleasant recall • Ease of procedure • No airway • Prompt return to • Ideal conditions for intervention or CV baseline procedure instability • No side effects (e.g. PONV)

Re Reade MC, Fi Finfer er S. S. N En Engl J J Med 2014;370:444-454. 454.