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Asian Healthcare Foundation (Registered Trust) Research wing of AIG
Recognized by Department of Scientific and Industrial Research, GOI Affiliated to
- Dr NTR University of Health Sciences
- University of Hyderabad (Ranked1)
Research at Asian Institute of Gastroenterology OMED Center of - - PowerPoint PPT Presentation
Research at Asian Institute of Gastroenterology OMED Center of - - PowerPoint PPT Presentation
Research at Asian Institute of Gastroenterology OMED Center of Excellence and Tertiary care Referral Center DSIR Recognized Translational Research Center Pradeep R Surgical Gastroenterologist Asian Institute of Gastroenterology
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Research and Training Activities
- Research grants obtained from federal agencies
- ICMR
- DBT
- DBT-Wellcome Trust India Alliance
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Areas of Research
- Inflammatory bowel disease: N=900
- Chronic pancreatitis: N=310;
- Gall stone disease: N=1200
- Liver disease including viral hepatitis N=4800
- Non alcoholic fatty liver disease
- Periampullary carcinoma: N=40
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Nature of data
- Patient information: Personal details, disease characters
- Clinical profiling:
- Investigations:
- Medications:
- Follow up
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Etiopathogenesis
Metabolomics
Genomics (Genes) Transcriptomics (Transcripts – mRNA) Proteomics
Systems Biology Approach
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- Etiopathogenesis:
Targeted Therapies can be developed using technological resources Biomarkers: Diagnosis or Prognosis
Basic Research
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Intestinal Disease
- Much attention is being focused on
- inflammatory bowel diseases
– Increasing prevalence – Controversy (Auto immunity and Inflammation) – (Ind. J. Gastroenterol 2009; 28: 169-174). – (Journal of Gastroenterology and Hepatology, 2010; 26:694-699).
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Meta Genomics
– We have thus embarked on obtaining detailed data on intestinal microflora in patients diagnosed for inflammatory bowel disease/Irritable bowel syndrome employing next generation sequencing. (BGI)
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Specific objectives
- To
find
- ut
predominant bacterial phylotypes associated with IBS. These bacteria may serve as biomarkers for IBS diagnosis.
- Comparative profiling of microbial flora in IBS and HCs.
- To identify the ideal probiotic strain for IBS patients.
- This project may help to develop and evaluate new
treatment alternatives based
- n
the microbiota alterations present in IBS patients.
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Intestinal Tuberculosis
356 638 750 740 745
2007 JUL-DEC 2008 2009 2010 2011
MTB
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> 3000 patients
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Hepatitis B data at AIG
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Hepatitis B Virus genotype B identified in India-1st Report
Ann Hepatol 2009 Jul-Sep; 8(3):269-70.
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42% 45% 10% 1% 2%
Genotype-1 Genotype-3 Genotype-4 Genotype-6 Genotype-3&4 (MIXED)
Hepatitis C
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Pancreas
- Chronic pancreatitis(Idiopathic:Tropical)
- Predicting Prediabetes in chronic pancreatitis
- Periampullary carcinoma- miRNA profiling
- Gene silencing
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T helper cell profiling in chronic pancreatitis
Subjects - >5000 Data set / Sub - 40
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miRNA profiling in periampullary carcinoma
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Micro array
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Quantitative Data
847 miRNA
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Gallstone disease
1268 patients
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