Program of Mental Health Research, QIMR Berghofer Michael - - PowerPoint PPT Presentation

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Program of Mental Health Research, QIMR Berghofer Michael - - PowerPoint PPT Presentation

Aug 13, 2023 280 likes •401 views

Program of Mental Health Research, QIMR Berghofer Michael Breakspear Coordinator, Program of Mental Health, QIMR Berghofer Psychiatrist, Brisbane Womens Correctional Centre Chair, Herston Imaging Centre Research Advisory Group and

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Program of Mental Health Research, QIMR Berghofer

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  • Chair, Metro North Research Collaborative Committee

Michael Breakspear

Metro North Mental Health

Research Review

2014

  • Coordinator, Program of Mental Health, QIMR Berghofer
  • Psychiatrist, Brisbane Women’s Correctional Centre
  • Chair, Herston Imaging Centre Research Advisory Group and

Scientific Committee

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Program of Mental Health and Complex Disorders

100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression 100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression

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50 100 Number (thousands) 20 40 60 80 100 Age Other Inflammatory heart disease Peripheral vascular disease Stroke Ischaemic heart disease 100 Number (thousands) 50 100 20 40 60 80 100 Age Other Inflammatory heart disease Peripheral vascular disease Stroke Ischaemic heart disease

Mental Illnesses are the leading cause of illness, loss of func3on, death and disability in adolescents and young adults in Australia. Mental Illness Cardiovascular Disease This impacts directly on society through health costs (especially rising costs of demen3a), loss of func3oning (especially depression), injury (drug and alcohol harm) and premature death (suicide and MVA leading causes of death for ages 18-35). Suicide is the leading cause of death in young adult males, and the third leading cause of YLL in males over all ages.

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Youth Mental Health Research

100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression 100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression

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50 100 Number (thousands) 20 40 60 80 100 Age Other Inflammatory heart disease Peripheral vascular disease Stroke Ischaemic heart disease 100 Number (thousands) 50 100 20 40 60 80 100 Age Other Inflammatory heart disease Peripheral vascular disease Stroke Ischaemic heart disease

Mental Illness Cardiovascular Disease In contrast to the major medical disorders, mental health impacts most greatly on young people Benefits of Youth Mental Health Research

  • 1. Prevent the risks and harm before they occur
  • 2. A small adjustment of brain development can have major

long term implica3ons

  • 3. Would put QLD squarely on the map of mental health

research and policy (currently dominated by Vic, ACT, NSW).

  • 4. Would strengthen the reciprocal exchange between QLD

Health, QIMR and the university sector

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5 10 Number (thousands) 20 40 60 80 100 Age Other Benzodiazepine dependence Hepatitis B Suicide & self-inflicted Cannabis dependence Hepatitis C Heroin dependence

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5 10 Number (thousands) 20 40 60 80 100 Age Other Benzodiazepine dependence Hepatitis B Suicide & self-inflicted Cannabis dependence Hepatitis C Heroin dependence

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20 40 Number (thousands) 20 40 60 80 100 Age Other Stroke Ischaemic heart disease

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Number (thousands)

Illicit drugs Cholesterol The harm from risks occur up to 6 decades before those of medical diseases

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Juvenile Rodent Drug exposure Preclinical imaging Adolescent Schoolies week Transla3onal imaging

At QIMR we focus on these serious and prevalent disorders - depression, schizophrenia, bipolar disorder, drug and alcohol use and demen3a We are uniquely posi3oned to iterate between basic, preclinical and transla3onal research

Program of Mental Health and Complex Disorders

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70 “At risk” (young people with a first degree relative with BP) 40 “Bipolar” (young people with BP) 100 “Controls” (healthy young people)

Bipolar Kids and Sibs Study

100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression 100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression

The goal of this project is to follow these young people (especially the high risk) through the peak period

  • f conversion to bipolar disorder

(i.e. the occurrence of a manic episode) Alistair Perry, Gloria Roberts, Anton Lord, Vinh Nguyen, Philip Mitchell

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Left sided network weaker in the high risk group, centre on hubs in IFG and AI

Roberts/Perry, Mitchell, Breakspear (in review)

Right sided network weaker in the high risk group, centred on hubs in IFG and AI

Bipolar Kids and Sibs Study

100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression 100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression

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Depression and Demen=a research

Unfortunately as mental health declines, the burden of demen3a arises

Anxiety, depression Dementia

Demen3a will soon become the leading cause of illness burden in Australian society. Current imaging and laboratory tests are insensi3ve to the early changes that precede demen3a

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Prospective imaging study of ageing

100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression 100 50 Number (thousands) 20 40 60 80 100 Age Other Schizophrenia Personality disorders Alcohol dependence Anxiety & depression

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20 40 Number (thousands) 20 40 60 80 100 Age Other Migraine Parkinson's disease Vision loss Adult-onset hearing loss Dementia

rso’s rso’s

arinsn’s 100 20 40 Number (thousands) 20 40 60 80 100 Age Other Migraine Parkinson's disease Vision loss Adult-onset hearing loss Dementia

?

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Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)

Michael Breakspear QIMR Berghofer Nick Martin QIMR Berghofer Gerard Byrne University of Queensland Stephen Rose CSIRO Olivier Salvado CSIRO Christine Guo QIMR Berghofer Gail Robinson University of Queensland Margie Wright University of Queensland Nancy Pachana University of Queensland Osvaldo Almeida University of Western Australia

Core Investigators Prospective imaging study of ageing

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Other Brisbane Collaborations

Interocep5ve disturbances in major depression Guo/Nguyen/Hye\/Gray/Breakspear et al Predic5ng impulsivity in Parkinson’s Disease following DBS Mosley/Perry/Breakspear + Silburn team Using brain network imaging to iden5fy epilepsy focus Guo/Nguyen/Breakspear + Dionisio team (a) Neuroinflamma5on in schizophrenia Burgher/Breakspear + James Sco\ + Paul Cumming Brain dysfunc5on in delirium Breakspear + Geriatric team (RBWH, TPCH)