Program of Mental Health Research, QIMR Berghofer
Michael Breakspear Coordinator, Program of Mental Health, QIMR Berghofer • Psychiatrist, Brisbane Women’s Correctional Centre • Chair, Herston Imaging Centre Research Advisory Group and Chair, Metro North Research Collaborative Committee • • Scientific Committee Metro North Mental Health Research Review 2014
Program of Mental Health and Complex Disorders Mental Illness Cardiovascular Disease 100 100 50 50 Other Other Other Other Schizophrenia Schizophrenia Inflammatory heart disease Inflammatory heart disease Peripheral vascular disease Peripheral vascular disease Personality disorders Personality disorders Stroke Stroke Alcohol dependence Alcohol dependence Ischaemic heart disease Ischaemic heart disease Anxiety & depression Anxiety & depression Number (thousands) Number (thousands) Number (thousands) Number (thousands) 50 50 0 0 0 0 100 100 0 0 20 20 40 40 60 60 80 80 100 100 100 100 0 0 20 20 40 40 60 60 80 80 100 100 Age Age Age Age Mental Illnesses are the leading cause of illness, loss of func3on, death and disability in adolescents and young adults in Australia. This impacts directly on society through health costs (especially rising costs of demen3a), loss of func3oning (especially depression), injury (drug and alcohol harm) and premature death (suicide and MVA leading causes of death for ages 18-35). Suicide is the leading cause of death in young adult males, and the third leading cause of YLL in males over all ages. �� ��
Youth Mental Health Research Mental Illness Cardiovascular Disease The harm from risks occur up to 6 decades before those of medical diseases 100 100 Other Other 50 50 Inflammatory heart disease Inflammatory heart disease Other Other Peripheral vascular disease Peripheral vascular disease Schizophrenia Schizophrenia Stroke Stroke Personality disorders Personality disorders Ischaemic heart disease Ischaemic heart disease Alcohol dependence Alcohol dependence 40 Anxiety & depression Anxiety & depression Number (thousands) Number (thousands) Other Stroke Other Other Number (thousands) Number (thousands) 10 10 Ischaemic heart disease Benzodiazepine dependence Benzodiazepine dependence 50 50 Hepatitis B Hepatitis B Suicide & self-inflicted Suicide & self-inflicted Cannabis dependence Cannabis dependence Hepatitis C Hepatitis C Number (thousands) Number (thousands) Number (thousands) Number (thousands) Heroin dependence Heroin dependence 20 5 5 0 0 100 100 0 0 20 20 40 40 60 60 80 80 100 100 0 0 Age Age 100 100 0 0 20 20 40 40 60 60 80 80 100 100 Age Age In contrast to the major medical disorders, mental 0 0 0 100 100 0 0 20 20 40 40 60 60 80 80 100 100 100 100 0 20 40 60 80 100 Age Age Age health impacts most greatly on young people Cholesterol Illicit drugs Benefits of Youth Mental Health Research 1. Prevent the risks and harm before they occur 2. A small adjustment of brain development can have major � � � ������ ������ long term implica3ons 3. Would put QLD squarely on the map of mental health research and policy (currently dominated by Vic, ACT, NSW). 4. Would strengthen the reciprocal exchange between QLD Health, QIMR and the university sector ������ � � �� �� �� �� ��
Program of Mental Health and Complex Disorders At QIMR we focus on these serious and prevalent disorders - depression, schizophrenia, bipolar disorder, drug and alcohol use and demen3a Drug Juvenile exposure Rodent Preclinical imaging Schoolies Transla3onal week Adolescent imaging We are uniquely posi3oned to iterate between basic, preclinical and transla3onal research
Bipolar Kids and Sibs Study 70 “At risk” (young people with a 40 “Bipolar” 100 “Controls” first degree relative with BP) (young people with BP) (healthy young people) 50 50 Other Other Schizophrenia Schizophrenia Personality disorders Personality disorders Alcohol dependence Alcohol dependence Anxiety & depression Anxiety & depression Number (thousands) Number (thousands) The goal of this project is to follow these young people (especially the high risk) through the peak period of conversion to bipolar disorder 0 0 100 100 0 0 20 20 40 40 60 60 80 80 100 100 (i.e. the occurrence of a manic Age Age episode) Alistair Perry, Gloria Roberts, Anton Lord, Vinh Nguyen, Philip Mitchell
Bipolar Kids and Sibs Study Left sided network weaker in the high risk group, centre on hubs in IFG and AI Right sided network weaker in the high risk group, centred on hubs in IFG and AI 50 50 Other Other Schizophrenia Schizophrenia Personality disorders Personality disorders Alcohol dependence Alcohol dependence Anxiety & depression Anxiety & depression Number (thousands) Number (thousands) 0 0 100 100 0 0 20 20 40 40 60 60 80 80 100 100 Age Age Roberts/Perry, Mitchell, Breakspear (in review)
Depression and Demen=a research Unfortunately as mental health declines, the burden of demen3a arises Anxiety, depression Dementia Demen3a will soon become the leading cause of illness burden in Australian society. Current imaging and laboratory tests are insensi3ve to the early changes that precede demen3a
Prospective imaging study of ageing 50 50 Other Other Other Other Migraine Migraine 40 40 Schizophrenia Schizophrenia Parkinson's disease Parkinson's disease Personality disorders Personality disorders Vision loss Vision loss Alcohol dependence Alcohol dependence Adult-onset hearing loss Adult-onset hearing loss Anxiety & depression Anxiety & depression Dementia Dementia Number (thousands) Number (thousands) Number (thousands) Number (thousands) 20 20 0 0 0 0 100 100 0 0 20 20 40 40 60 60 80 80 100 100 100 100 0 0 20 20 40 40 60 60 80 80 100 100 Age Age Age Age ��r���so�’s ? ��r���so�’s �ar�ins�n’s �� ��
Prospective imaging study of ageing Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA) Core Investigators Gail Robinson Michael Breakspear Nick Martin Nancy Pachana Olivier Salvado University of Queensland QIMR Berghofer QIMR Berghofer University of Queensland CSIRO Christine Guo Stephen Rose Margie Wright Osvaldo Almeida Gerard Byrne QIMR Berghofer CSIRO University of Queensland University of Western Australia University of Queensland
Other Brisbane Collaborations Predic5ng impulsivity in Parkinson’s Disease Using brain network imaging to iden5fy epilepsy Interocep5ve disturbances in major following DBS focus depression Mosley/Perry/Breakspear + Silburn team Guo/Nguyen/Breakspear + Dionisio team Guo/Nguyen/Hye\/Gray/Breakspear et al (a) Brain dysfunc5on in delirium Neuroinflamma5on in schizophrenia Breakspear + Geriatric team (RBWH, TPCH) Burgher/Breakspear + James Sco\ + Paul Cumming
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