Prize Prize 2007 2007 Gnther Laukien Prize Gnther Laukien Prize - PowerPoint PPT Presentation

Günther Günther Laukien Laukien Prize Prize 2007 2007

Günther Laukien Prize Günther Laukien Prize Established in 1999 to honour the memory of Established in 1999 to honour the memory of Professor Günther Laukien, co-founder of Professor Günther Laukien, co-founder of Bruker instruments, the Laukien Prize carries Bruker instruments, the Laukien Prize carries a monetary award of $ 20’000.—, funded by a monetary award of $ 20’000.—, funded by Bruker Instruments, and is intended to Bruker Instruments, and is intended to recognize cutting edge experimental NMR recognize cutting edge experimental NMR research with a high probability of enabling research with a high probability of enabling beneficial new applications. beneficial new applications.

Günther Günther Laukien Laukien

JURY OF GÜ ÜNTHER LAUKIEN PRIZE NTHER LAUKIEN PRIZE JURY OF G JURY OF GÜNTHER LAUKIEN PRIZE 2007 2007 2007 Truman R. Brown Truman R. Brown Angela Gronenborn Angela Gronenborn Lewis Kay Lewis Kay Alex Pines Alex Pines James Prestegard James Prestegard Kurt W. Zilm Kurt W. Zilm Richard R. Ernst Richard R. Ernst

Former Winners of Günther Laukien Prize Former Winners of Günther Laukien Prize 1999: Konstantin Pervushin, Roland Riek, Gerhard Wider, Kurt Wüthrich 1999: Konstantin Pervushin, Roland Riek, Gerhard Wider, Kurt Wüthrich 2000: Lucio Frydman 2000: Lucio Frydman 2001: Klaas Paul Prüssmann, Markus Weiger, Peter Bösiger 2001: Klaas Paul Prüssmann, Markus Weiger, Peter Bösiger 2002: Ad Bax, Axel Bothner-By, James H. Prestegard 2002: Ad Bax, Axel Bothner-By, James H. Prestegard 2003: Jacob Schaefer 2003: Jacob Schaefer 2004: Lewis E. Kay 2004: Lewis E. Kay 2005: Stephan Grzesiek 2005: Stephan Grzesiek 2006: Thomas Szyperski, Eriks Kup č e, Ray Freeman, Rafael Brüschweiler 2006: Thomas Szyperski, Eriks Kup č e, Ray Freeman, Rafael Brüschweiler

Speeding-Up Speeding-Up Multi - dimensional NMR Multi - dimensional NMR

20 NOMINATIONS 20 NOMINATIONS A A 2007 2007 B B C + D + E C + D + E F F G G H + I H + I K K L All of them excellent, L All of them excellent, M M N N but one of them but one of them N + O + P N + O + P Q + R Q + R SUPERB !!! SUPERB !!! S S T T U + V + W U + V + W X X Y Y Z Z ZZ ZZ

H ow to get H ow to get out of the noise ? out of the noise ?

DN P gets you DN P gets you out of the noise ! out of the noise !

April 1959 SCIENTIFIC AMERICAN

1972 at MIT 1972 at MIT

1975 1975

1991 1991

Adventures in Biological Solid State NMR Adventures in Biological Solid State NMR 1981 13 CO-labeled lipids 1981 13 CO-labeled lipids 1981 Dipolar recouping (DIPSHIFT) 1981 Dipolar recouping (DIPSHIFT) 1983 15 N lysine-labeled bacteriorhodopsin 1983 15 N lysine-labeled bacteriorhodopsin 1987 Rotational resonance (R 2 ) 1987 Rotational resonance (R 2 ) 1992 Improved recoupling (MELODRAMA) 1992 Improved recoupling (MELODRAMA)

Bob’s career as a noise Bob’s career as a noise generator generator

DN P gets you DN P gets you out of the noise ! out of the noise !

Enhancement up to 40x for 13 C

The seminal contributions consist of The seminal contributions consist of five key elements . five key elements .

(i) The development of high-power (i) The development of high-power high-frequency gyrotron microwave sources high-frequency gyrotron microwave sources RICHARD J. TEMKIN, RICHARD J. TEMKIN, Associate Director, Associate Director, MIT Plasma Science and Fusion Center MIT Plasma Science and Fusion Center Waves and Beams Divsion Waves and Beams Divsion

(ii) the development of MAS NMR probes with the (ii) the development of MAS NMR probes with the possibility of DNP sensitivity enhancement, in possibility of DNP sensitivity enhancement, in addition to full solid-state NMR capabilities and low- addition to full solid-state NMR capabilities and low- temperature operation temperature operation

the development of MAS the development of MAS NMR probes with the NMR probes with the possibility of DNP possibility of DNP sensitivity enhancement, sensitivity enhancement, in addition to full solid- in addition to full solid- state NMR capabilities and state NMR capabilities and low-temperature operation low-temperature operation

Enhancement of 400x

(iii) investigation of the basic mechanism of (iii) investigation of the basic mechanism of DNP and its optimization for achieving DNP and its optimization for achieving maximum sensitivity enhancement. maximum sensitivity enhancement.

DNP by Thermal Mixing DNP by Thermal Mixing ω e - ω H ω e - ω H

EPR EPR NMR NMR

DNP by Thermal Mixing

Applications to Biological Solids Applications to Biological Solids

(iv) development of novel biradical dopant molecules (iv) development of novel biradical dopant molecules for efficient DNP enhancement in frozen solutions of for efficient DNP enhancement in frozen solutions of bio-molecules bio-molecules

TOTAPOL TOTAPOL

(v) demonstrating the feasibility of in situ temperature (v) demonstrating the feasibility of in situ temperature jump experiments for sensitivity-enhanced liquid-state jump experiments for sensitivity-enhanced liquid-state NMR NMR

Dynamic nuclear polarization is an old effect, Dynamic nuclear polarization is an old effect, going back more than fifty years, that has been going back more than fifty years, that has been revived by the work of Robert G. Griffin and revived by the work of Robert G. Griffin and coworkers. coworkers. In the mean time, DNP has found related In the mean time, DNP has found related applications also in ex-situ field-cycling liquid- applications also in ex-situ field-cycling liquid- state NMR and in bio-medical imaging, for state NMR and in bio-medical imaging, for example by Klaes Golman and coworkers. example by Klaes Golman and coworkers.

e h e e t h h o t t o t o s t t n s s o n n o i o t a i t i l a t a u l l t u u a t t r a a g r r n g g n o n C o o C C ! ! e ! z e e i z r z i P r i r P P d e d d v e e r v v e r r s e e e s s e d e d l d l e l l l w e l e w w

Please send in Please send in Well-documented Nominations Well-documented Nominations (work to be honored, CV, publications) (work to be honored, CV, publications) for the for the Günther Laukien Prize 2008 Günther Laukien Prize 2008