Prize Prize 2007 2007 Gnther Laukien Prize Gnther Laukien Prize - - PowerPoint PPT Presentation

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Prize Prize 2007 2007 Gnther Laukien Prize Gnther Laukien Prize - - PowerPoint PPT Presentation

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Gnther Gnther Laukien Laukien Prize Prize 2007 2007 Gnther Laukien Prize Gnther Laukien Prize Established in 1999 to honour the memory of Established in 1999 to honour the memory of Professor Gnther Laukien, co-founder of

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Günther Laukien

Prize 2007

Günther Laukien

Prize 2007

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Günther Laukien Prize Günther Laukien Prize

Established in 1999 to honour the memory of Professor Günther Laukien, co-founder of Bruker instruments, the Laukien Prize carries a monetary award of $ 20’000.—, funded by Bruker Instruments, and is intended to recognize cutting edge experimental NMR research with a high probability of enabling beneficial new applications. Established in 1999 to honour the memory of Professor Günther Laukien, co-founder of Bruker instruments, the Laukien Prize carries a monetary award of $ 20’000.—, funded by Bruker Instruments, and is intended to recognize cutting edge experimental NMR research with a high probability of enabling beneficial new applications.

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Günther Laukien Günther Laukien

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JURY OF GÜNTHER LAUKIEN PRIZE 2007 JURY OF G JURY OF GÜ ÜNTHER LAUKIEN PRIZE NTHER LAUKIEN PRIZE 2007 2007

Truman R. Brown Angela Gronenborn Lewis Kay Alex Pines James Prestegard Kurt W. Zilm Richard R. Ernst Truman R. Brown Angela Gronenborn Lewis Kay Alex Pines James Prestegard Kurt W. Zilm Richard R. Ernst

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1999: Konstantin Pervushin, Roland Riek, Gerhard Wider, Kurt Wüthrich 2000: Lucio Frydman 2001: Klaas Paul Prüssmann, Markus Weiger, Peter Bösiger 2002: Ad Bax, Axel Bothner-By, James H. Prestegard 2003: Jacob Schaefer 2004: Lewis E. Kay 2005: Stephan Grzesiek 2006: Thomas Szyperski, Eriks Kupče, Ray Freeman, Rafael Brüschweiler 1999: Konstantin Pervushin, Roland Riek, Gerhard Wider, Kurt Wüthrich 2000: Lucio Frydman 2001: Klaas Paul Prüssmann, Markus Weiger, Peter Bösiger 2002: Ad Bax, Axel Bothner-By, James H. Prestegard 2003: Jacob Schaefer 2004: Lewis E. Kay 2005: Stephan Grzesiek 2006: Thomas Szyperski, Eriks Kupče, Ray Freeman, Rafael Brüschweiler

Former Winners of Günther Laukien Prize Former Winners of Günther Laukien Prize

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Speeding-Up

Multi-dimensional NMR

Speeding-Up

Multi-dimensional NMR

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A B C + D + E F

G

H + I K L M N N + O + P Q + R S T U + V + W X Y Z ZZ A B C + D + E F

G

H + I K L M N N + O + P Q + R S T U + V + W X Y Z ZZ

All of them excellent, but one of them SUPERB !!! All of them excellent, but one of them SUPERB !!! 20 NOMINATIONS 2007 20 NOMINATIONS 2007

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H ow to get

  • ut of the noise ?

H ow to get

  • ut of the noise ?
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DN P gets you

  • ut of the noise !

DN P gets you

  • ut of the noise !
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SCIENTIFIC AMERICAN

April 1959

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1972 at MIT 1972 at MIT

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1975 1975

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1991 1991

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Adventures in Biological Solid State NMR

1981

13CO-labeled lipids

1981 Dipolar recouping (DIPSHIFT) 1983

15N lysine-labeled bacteriorhodopsin

1987 Rotational resonance (R2) 1992 Improved recoupling (MELODRAMA)

Adventures in Biological Solid State NMR

1981

13CO-labeled lipids

1981 Dipolar recouping (DIPSHIFT) 1983

15N lysine-labeled bacteriorhodopsin

1987 Rotational resonance (R2) 1992 Improved recoupling (MELODRAMA)

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Bob’s career as a noise generator Bob’s career as a noise generator

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DN P gets you

  • ut of the noise !

DN P gets you

  • ut of the noise !
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Enhancement up to 40x for 13C

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The seminal contributions consist of

five key elements.

The seminal contributions consist of

five key elements.

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RICHARD J. TEMKIN,

Associate Director, MIT Plasma Science and Fusion Center Waves and Beams Divsion

RICHARD J. TEMKIN,

Associate Director, MIT Plasma Science and Fusion Center Waves and Beams Divsion

(i) The development of high-power high-frequency gyrotron microwave sources (i) The development of high-power high-frequency gyrotron microwave sources

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(ii) the development of MAS NMR probes with the possibility of DNP sensitivity enhancement, in addition to full solid-state NMR capabilities and low- temperature operation (ii) the development of MAS NMR probes with the possibility of DNP sensitivity enhancement, in addition to full solid-state NMR capabilities and low- temperature operation

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the development of MAS NMR probes with the possibility of DNP sensitivity enhancement, in addition to full solid- state NMR capabilities and low-temperature operation the development of MAS NMR probes with the possibility of DNP sensitivity enhancement, in addition to full solid- state NMR capabilities and low-temperature operation

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Enhancement of 400x

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(iii) investigation of the basic mechanism of DNP and its optimization for achieving maximum sensitivity enhancement. (iii) investigation of the basic mechanism of DNP and its optimization for achieving maximum sensitivity enhancement.

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DNP by Thermal Mixing DNP by Thermal Mixing ωe - ωH ωe - ωH

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EPR EPR NMR NMR

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DNP by Thermal Mixing

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Applications to Biological Solids Applications to Biological Solids

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(iv) development of novel biradical dopant molecules for efficient DNP enhancement in frozen solutions of bio-molecules (iv) development of novel biradical dopant molecules for efficient DNP enhancement in frozen solutions of bio-molecules

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TOTAPOL TOTAPOL

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(v) demonstrating the feasibility of in situ temperature jump experiments for sensitivity-enhanced liquid-state NMR (v) demonstrating the feasibility of in situ temperature jump experiments for sensitivity-enhanced liquid-state NMR

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Dynamic nuclear polarization is an old effect, going back more than fifty years, that has been revived by the work of Robert G. Griffin and coworkers. In the mean time, DNP has found related applications also in ex-situ field-cycling liquid- state NMR and in bio-medical imaging, for example by Klaes Golman and coworkers. Dynamic nuclear polarization is an old effect, going back more than fifty years, that has been revived by the work of Robert G. Griffin and coworkers. In the mean time, DNP has found related applications also in ex-situ field-cycling liquid- state NMR and in bio-medical imaging, for example by Klaes Golman and coworkers.

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C

  • n

g r a t u l a t i

  • n

s t

  • t

h e w e l l d e s e r v e d P r i z e ! C

  • n

g r a t u l a t i

  • n

s t

  • t

h e C

  • n

g r a t u l a t i

  • n

s t

  • t

h e w e l l d e s e r v e d P r i z e ! w e l l d e s e r v e d P r i z e !

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Please send in Well-documented Nominations

(work to be honored, CV, publications) for the

Günther Laukien Prize 2008

Please send in Well-documented Nominations

(work to be honored, CV, publications) for the

Günther Laukien Prize 2008