Prion diseases Mabbott et al. Nature Reviews Microbiology advance - - PowerPoint PPT Presentation

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Nov 12, 2023 273 likes •403 views

Prion diseases Mabbott et al. Nature Reviews Microbiology advance online publication; published online 06 February 2006 | doi:10.1038/nrmicro1346 Infected brains CJD - human BSE - cow kuru - human BSE vCJD Infected animals Incidence of

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Mabbott et al. Nature Reviews Microbiology advance online publication; published online 06 February 2006 | doi:10.1038/nrmicro1346

Prion diseases

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Infected brains BSE - cow CJD - human kuru - human

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Infected animals entering food supply Incidence of vCJD

BSE  vCJD

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Structure of PrP

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PrPc PrPSc

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Models for conversion from PrPc to PrPSc

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Seeding models of prion propagation

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Mutations in Prnp associated with human TSEs

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Role of cytoplasmic PrP in neurodegenerative disease

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Lee et al., 2000

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