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PREVALENZA : ANNI 80 ANNI 80 Comunit Europea 2000 6403 sera - - PowerPoint PPT Presentation
PREVALENZA : ANNI 80 ANNI 80 Comunit Europea 2000 6403 sera - - PowerPoint PPT Presentation
PREVALENZA : ANNI 80 ANNI 80 Comunit Europea 2000 6403 sera Tissue transglutaminase testing 134 tTg+ ( > 7) 3 tTg - (5.1-6.9), EMA + PREVALENZA 1: 49 8 CD without 6 CD diagnosed 120 antibody + GFD diagnosed between 2000 33tTg >
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8 CD without GFD diagnosed before 2000 Tissue transglutaminase testing 6403 sera 134 tTg+ ( > 7) 3 tTg - (5.1-6.9), EMA + 6 CD diagnosed between 2000 and 2002 120 antibody + 33tTg > 7, EMA – 87 tTG > 7, EMA 123 individuals to be biopsied 81 (66%) aggred on biopsy 17 (14%) refused 21 (17%) could be not be traced 4 (3%) had died after serum sampling 40 biopsied so far
Comunità Europea 2000 PREVALENZA 1: 49
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Prevalence of coeliac disease among 5055 pregnant women
TGASE Units n EMA + EMA
- DQ
2 DQ 8 DQ2/ 8 DQ2/ 8- DIAGNOSI S RATE TGASE > 9 UI 48 48 42 4 1 1 48 Coeliac >7 TGASE< 9 UI 10 3 7 4 1
- 5
6 Coeliacs >5 TGASE<7 UI 20 20 6 1 13 2 Coeliacs TGASE < 5 4977 Negative TOTAL 5055 51 27 50 6 2 20
New cases
56 Known cases 12 Known 12 1:4,6
1:74
TUTTA LA CAMPANIA 2000
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Italian areas Immigrant CD patients Total CD patients % ( n = 34 ) ( n = 1764 )
NORTHERN 11 615 1.8 CENTER 15 603 2.5
SOUTHERN – INSULAR*
8 546 1.5
____________________________________________________________________
* Insular = Sicily
Celiaci tra bimbi immigrati in Italia
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TABLE 1: Geographic distribution in our country of the immigrant CD patients
_______________________________________________________ EAST EUROPE : Macedonia ( 1 ), Rumania ( 3 ), Poland ( 2 ), Russia ( 2 ), Serbia ( 1 ), Albania ( 5 ) NORTH AFRICA : Egypt ( 1 ), Morocco ( 6 ), Tunisia ( 4 ), Saharawi ( 2 ) WEST AFRICA : Cape Verde ( 1 ) EAST AFRICA : Somalia ( 1 ) MIDDLE- EAST : Syria ( 1 ) SOUTHERN : Sri-Lanka ( 1 ), Pakistan ( 3 ) ASIA ______________________________________________________
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QUEST’ANNO 2006
1:33 1:41 1:60 1:50 Tunisia 1: 45
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In the recent past One in every 50-100 common people, many apparently healthy
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epilessia Lesioni smalto dentario esofagite cardiomiopatia pancreatite diabete colite ulcere amenorrea Dermatite Erpetiforme artrite anemia neurite distrofia nefrite diarrea epatite gastrite tiroidite iridociclite atassia
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- Epilessia e calcificazioni
cerebrali
- Sclerosi Multipla
- Emicrania
capelli
- Alopecia
- Riduzione diametro
capelli
- Atassia glutine
dipendente
- Ipoacusia
Cataratta
- Uveite
- Cataratta
- Lesioni smalto
dentario
- Stomatite aftosa
- Modifiche salivare
- Tiroidite
- Carcinoma papillare della
tiroide
- Iperparatiroidismo
- GERD
(Paterson-Kelly)
- GERD
- Esofagite eosinofila
- Sindrome di Plummer-Vinson
(Paterson-Kelly) Sintomi Sintomi atipici Patologie associate Complicanze
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- Cardiomiopatia
- Fibrillazione
atriale
- Sarcoidosi
- Emosiderosi
- Vomito
- Gastrite
linfocitaria
- Diabete
- Insufficienza
Pancreatica
- Epatite
- Cirrosi biliare
primitiva
- Colangite sclerosante
- Ipertransaminasemia
- Osteoporosi
- Fratture
- Debolezza
muscolare
- Iper-CK-emia
- Sjögren
Sintomi Sintomi atipici Patologie associate Complicanze
- Depressione
- Ansietà
- Disturbi della
sfera affettiva
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- Diarrea
- Dolori addominali
- IBS
- Colite
- Tumori Intestinali
- Cavitazione
linfonodi mesenter
- Amenorrea
- Infertilità
- Aborti ricorrenti
- Nefrite
- Insufficienza
renale cronica
- Dermatite
Erpetiforme
- Psoriasi
- Keratosis Pilaris
- Xerosi cutanea
- Artrite
- Artrite
- Artrite reumatoide
- Anemia ferrocarenziale
- Anemia megaloblastica
- Porpora trombocitopenica
- Trombocitosi
Sintomi Sintomi atipici Patologie associate Complicanze
- Iposplenismo
- Iposplenismo
- Neuropatie mot
- Gangliopatie
sensoriali
- RLS (Restless
Leg Syndrome)
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www.medicel.unina.it
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But know how and diagnostic facilities VERY different
Most patients cared for appropriately Few patients cared for well Care very occasional, start after 6 years ! What about the infants ?
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Que c’es qu il a en Algerie ?
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Le celiaquie en Algerie en 2020
Population 33.769.669 Trouble digestif 51.040 Enfant 0-14 an 8.878.665 Anemia 24.019 CELIAQUE 337.697 Osteoporosis 18.014 ENFANTS Celiaque 88.787 Anomalies du foie 6.005 Arête de Croissance 4.000 COUT DE LA CELIAQUE € 123.410.460 Dinar 123.420.500.000 Excess de mort 14.118
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Consumption of wheat per capita (Kcal/Day)
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Rise in the consumption of wheat flour
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Pasta consumption in the E.U. (1990 - 2008)
SLIDE 20
CONSUMPTION OF PASTA PER CAPITA
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Production of pasta in the world
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SLIDE 21
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SLIDE 22
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Expected N. of Cases, Health Cost and related Deaths
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+ *
- $
- $
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$
- 8/777
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The Past : < 100.000
Clinical Clear CD Potential CD Gluten Sensitive
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The Present : about 1 Million
Clinical Clear CD Potential CD Gluten Sensitive
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The Future > 5 Millions
Potential CD Gluten Sensitive Clinical Clear CD
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