Practical strategies for providing rats with a complex environment - - PowerPoint PPT Presentation

practical strategies for providing rats with a complex
SMART_READER_LITE
LIVE PREVIEW

Practical strategies for providing rats with a complex environment - - PowerPoint PPT Presentation

Practical strategies for providing rats with a complex environment Kate Shenton NC3Rs workshop for technicians. IAT Congress 2017 March 2017 Practical strategies for providing rats with a complex environment Kate Shenton NC3Rs workshop for


slide-1
SLIDE 1

Kate Shenton

March 2017

Practical strategies for providing rats with a complex environment

NC3Rs workshop for technicians. IAT Congress 2017

slide-2
SLIDE 2

Practical strategies for providing rats with a complex environment

Kate Shenton

NC3Rs workshop for technicians. IAT Congress 2017 March 2017

slide-3
SLIDE 3
  • Permanent housing
  • Intermittent access to enriched area

Practical strategies for providing rats with a complex environment

slide-4
SLIDE 4

Conventional caging used. Internal height 19cm.

slide-5
SLIDE 5

Modified rabbit exercise pen

5

slide-6
SLIDE 6

Playtime for telemetry animals

6

  • How it started
  • What we did
  • What we found
  • What we learnt
  • start slowly and build up the time spent in the play/exercise area
  • no aggression seen between mixed groups of mature male animals
  • animals enjoy utilising vertical space
slide-7
SLIDE 7

7

https://az.box.com/s/jy9u9uqtdege509aqxa 0grzaybfmyamg

Playtime for telemetry animals – video footage

https://az.box.com/s/df1mqdc24s6htv7quk p3231o2md9p1te

slide-8
SLIDE 8

Providing a play / exercise / socialisation area

8

  • Want to give it a go?
  • What have you already got that you might be able to utilise?

– Examples: modified rabbit exercise pen, rabbit housing and diet bin. Use your imagination!

  • Other options to consider are commercially available pet

ferret/parrot cages

slide-9
SLIDE 9

Modified rabbit exercise pen

9

slide-10
SLIDE 10

Modified diet bin

10

slide-11
SLIDE 11

Modified rabbit housing

11

This is actually used as a home cage but where that is not suitable this could be used as an exercise / play area.

slide-12
SLIDE 12

Alternative housing

12

To provide rats with continuous opportunities to carry out the activities a play area offers. Options looked at:

  • Modified rabbit cages
slide-13
SLIDE 13

13

  • Commercially available
  • ptions
  • rats in the enriched cage over

the conventional cage (18cm high) saw better muscle strength in an incline plane test.

  • Body weight and food

consumption were unaffected.

  • The behaviour repertoire

differed as rats in enriched cages could stretch and climb. Rats in the conventional cage spent a greater proportion of their time resting.

Alternative housing

slide-14
SLIDE 14

14

Alternative housing

Double level cages

  • Widely commercially available
  • Increased height, reduced floor

space Rats reported to ‘hang out’ on the platform. Increased playing and activity suspected but requires measuring.

slide-15
SLIDE 15

Barriers to implementation & considerations to be made

15

  • Making it work within the constraints of your facility and science.

– For example IVC facilities. GLP studies. Financial considerations. Space

  • available. Time available. Wash facilities.
  • Certification of play area contents- GLP required. Use of toys commercially made

for research dogs and primates.

  • Treats- to offer or not to offer? What to offer? How much? Certified?
  • What do you think the questions asked will be? How can you work around

concerns and constraints?

slide-16
SLIDE 16

16

Gathering some data. We would like to build up some scientific evidence to support the use of exercise time/areas and investigate the impact of these sessions on parameters such as stress hormone levels, bodyweight, lean tissue versus body fat composition, ultrasonic vocalisation Any other ideas of ways in which we can measure the affects of playtime? Any questions?

The next steps

slide-17
SLIDE 17

Confidentiality Notice

This file is private and may contain confidential and proprietary information. If you have received this file in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this file is not permitted and may be unlawful. AstraZeneca PLC, 1 Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0AA, UK, T: +44(0)203 749 5000, www.astrazeneca.com

17