Patient 1 Zinc Phosphide 23 y/o male ingested rodent pellets: Zn 3 P - - PDF document
Patient 1 Zinc Phosphide 23 y/o male ingested rodent pellets: Zn 3 P - - PDF document
Using the Poison Center as a Hazmat Resource Susan Smolinske MD, PharmD, DABAT, FAACT Director New Mexico Poison and Drug Information Center Patient 1 Zinc Phosphide 23 y/o male ingested rodent pellets: Zn 3 P 2 Awake but intubated
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Patient 1
Negative pressure
room
Phosphine monitoring
commenced
SCBA and Level 2
HazMat
Level > STEL
Staff refused to enter
Patient self-extubated Sensor positioned at
patients anus
Repositioned to staff
breathing space
Safe levels Patient reintubated
Levels rapidly dropped
Patient recovered
Patient 2 Zinc Phosphide
28-year-old man presented after ingestion
- f an unknown amount of Zn3P2
On arrival stable with no reported odor Intubated for airway protection Lavage returned 200 mL of white stuff, WBI Rectal tube inserted, waste double-bagged Admitted to ICU rather than isolation room
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Patient 2
At 18 hours staff report strong odor in room SCBA and Ph3 sensors brought in by Hazmat
team
One sensor had level above STEL ICU evacuated Patient moved to negative pressure room Patient had transient anemia and pulmonary
- complications. No staff illnesses
Patient 3 Zinc Phosphide
36-year-old man presented to ED 2 hours after ingesting
750 grams of 60% AlP pellets
Intubated, profused gray, green material came up
esophagus clogging suction tube
Material had garlic odor, causing pulmonary and ocular
irritation to staff
Patient moved outdoors, resuscitated 1 hour and died PPE was gloves, gowns, N-95 masks, higher levels not
available
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Patient 3
Hazmat called initially by canceled by IC
when he mistakenly thought it was phosgene and not phosphine
Hazmat reactivated, National Guard called High phosphine levels detected 11 days
later
Patient 3
Ventilator and ultrasound left outside in
rain with monitors, gurney, pumps due to monitoring inability
Two providers hospitalized for respiratory
distress
ED not usable for 2 days OMI consulted with poison center
regarding autopsy and burial precautions
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Patient 4 Cyanide
31 year old man
suicide with KCN
Resuscitated at the
scene
Transported to local
hospital
Intubated Supportive care antidote
Portable negative pressure room
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Patient 4
Poison center advised antidote while en
route to hospital (hydroxocobalamin)
Hospital personnel start calling poison
center concerned about contamination
Hospital put ambulances on divert but
accepting walk-ins with “informed consent” about potential toxic fumes
Patient 4
Hazmat was in the area doing a massive
preparedness exercise and did testing fairly quickly with negative results
Patient died and concern raised about autopsy;
ME was given PPE
The poison center was never given the IC name
and only communicated with hospital staff
Hazmat removed remaining packets of KCN
from patient’s home
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Patient 5 Mercury
Patient called 911 reporting mercury poisoning Paramedics called Poison Center to ask about
mercury poisoning
2 paramedics + 1 firefighter arrive on scene. Patient admitted to ED for bloody diarrhea.
Patient reported “working with metals, maybe mercury 3 days ago.”
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Accidental Mercury Poisoning
Patient brought contaminated grease pan with
him, which was doubled bagged at ED as well as clothes. Both bags sent to Safety Risk Services.
- DOH received call from UNM about case.
- Told patient had been cooking a powdered ore
in home oven with mercury to obtain gold
Photo of Ore
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Health Effects: Elemental Mercury
Symptoms may develop within a few hours Chills, metallic taste, mouth sores, swollen
gums, nausea, vomiting, abdominal pain, diarrhea, headache, weakness, confusion, shortness of breath, cough, chest tightness, bronchitis, pneumonia and kidney damage
ED Visit by ATSDR
Tests of patient on revealed:
Blood Mercury of 576 ug/L Urine Mercury of 1827 ug/L Notifiable Condition Level: Blood Mercury: >3 ug/L Urine Mercury: >5 ug/L
Patient started on oral chelation with
succimer
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Ambulance
DOH urged paramedics and firefighters to be
tested for mercury
Ambulance used to transport patient temporarily
‘retired’ until ambulance could be tested
Jerome analyzer rented and ambulance was
found ‘negative’ for mercury
Results for paramedics and firefighter were not
received until one month after the tests were run All results below notifiable condition level.
Mercury Levels in House
Patient’s house (a rental) was cordoned off after
informing home owner
DOH paid for an environmental consulting
company to monitor house outside and inside
Patient discharged on same day, under
supervision of physician
EPA uses ATSDR mercury action levels:
- <= 1 ug/m3: Level acceptable for occupancy of any
structure after a spill
- < 10 ug/m3: Level acceptable for objects (air around)
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Mercury Levels in House
In the kitchen, levels were 420 ug/m3 Other areas lower (23 ug/m3 by
washer/dryer)
Homeowner then wanted to know what
DOH could do about the house
Patient wanted his things out of house NMED was contacted but they could not
use emergency funds
EPA National Response Network
DOH discovered the EPA has a National
Response Network and a Mercury Team
Team mobilized to residence. EPA contractors conducted mercury monitoring
in the ambulance and ER
They tested the grease pan and clothes
(bagged) and both were hot (about 50 ug/m3) for mercury.
Also tested the ER chair where patient sat
(clothes had not been removed before transport). The chair was below 10 ug/m3
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EPA National Response Network
Ambulance tested and the biohazard bag was >
10 ug/m3.
No New Mexico protocol for clearing ambulance EPA suggested action level of 3 ug/m3 for “an
- ccupational or commercial setting where
mercury is not usually handled.”
Once bag removed, air in ambulance below 3
ug/m3
DOH + EMS Bureau then cleared (via letter) the
ambulance to resume service
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EPA National Response Network
EPA Team conducted air monitoring for mercury
vapors with a Lumex Mercury Analyzer— capable of detecting nanogram/m3 levels of Hg mercury vapor
EPA National Response Network
Just inside doorway, levels were 15 ug/m3 In order to reduce mercury levels, house
was actively vented
Heaters inside home set up with copious
blowers/fans to push vapors out of windows.
Vented air monitored to ensure
permissible exposure levels weren’t exceeded
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Complications
Homeowner was given choice: EPA can
clean up or she could pay to do it herself
She had house cleaned up but did not
coordinate with EPA
Homeowner-hired environmental
company: reported 0.00 ug/m3 mercury in the house
BUT, used Jerome meter and detection
limit is 1 ug/m3
Patient 6 Mercury: Day 1
2 children playing with vial, broke in bed, estimate 1 tsp
spilled
Recommendations:
Clean up per MI guidelines Shower and change clothes (resulted in drain being
contaminated)
Stat blood mercury Provided DOH phone number
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Follow up on Day 1
Caller states still beads visible in planks of
wood floor; she was going to vacuum
Recommended against vacuum Keep door closed and stay out of room
until plan for cleanup
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Follow up on day 4
Detailed self clean-up advice given
Contact insurance Remove carpeting Take remaining Hg to hazmat site (gave
address)
Follow up on day 5
Lab results on two less exposed children
return
Both 8 mcg/L (nl < 10) Normals are based on adult occupational
exposures
NHANES data shows 95% of children have
levels < 1)
The fact that index child’s level not back likely
indicates it is hig
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Follow up day 5 continued
Asked for seafood history; if negative
evacuate home, call contractor
Mother states no seafood; additional history is
that home has no AC, temperatures are 75 degrees or higher
Home evacuated; went to grandmother’s on
same property
On hold with Tricore 15 minutes or more lab
tech did not return to phone
Day 6
MD calls with mercury level of 67 mcg/L Chelation recommended directly to MD from consultant
Began to initiate process to obtain succimer
Family calls and still seeing beads in flooring after
extensive cleanup effort (ignored recommendation to call consultant)
History obtained that child has baseline developmental
disorders (spatial anxiety, abnormal sensory processing)
Child goes to ED to get Rx and resident says admission
needed
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Day 7
EPA notified and agreed to send a team
NRC notified (required to get EPA involved)
DOH notified Toxicology met EPA at patient’s home
Bedroom level exceeded limit of Lumex (> 50,000)
Required self-contained breathing protection
Clean-up efforts included
Mercury binding solution
Mercury vacuum
Heat and vent cycles
Entire room drywall and insulation removed
Two washing machines disposed (tried wash cycle with binding solution)
Wood flooring deemed the cause of remaining vapors
Sealed floor with polyurethane (ineffective)
Sealed floor with DuraPoxy (certified barrier)
Declared clear after 17 days of cleaning
EPA START team
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Day 8
Child gets first dose of succimer in ED She is sent home with 5 days worth of
medication (all we had)
Pharmacist recommended child swallow
capsules
We recommend putting in yogurt, applesauce
- r pudding
Subsequent mercury level is 12 mcg/L before
chelation
Lessons learned Mercury
Involve LEPC, NRC, DOH early if > 1 thermometer Get complete history (medical conditions, seafood consumption) Have family evacuate as soon as discovered Remove clothes and shoes then wipe with washcloth before
showering
Be more questioning about “pending labs” Wash hair with Selsun Blue or equivalent Use Selsun blue on dogs (not cats) Put all clothes, shoes and washcloths in sealed bags Figure out a better way to get succimer to patients
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What can we learn from these cases?
Call the poison center early When in doubt, remove patient’s clothes before transport to
prevent contamination in ER
We can activate Chempack and hazmat Identify an Incident Commander Double NG tube Lavage and WBI closed circuit Alert Hazmat early to obtain monitoring equipment Alert Hazmat early to obtain proper PPE Negative pressure room Limit patient movement to other areas Consult poison center regarding fatal hazmat cases
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New Mexico Poison Center
Cost analysis
PCCs save $13.00 for every $1.00 spent on PCC
support
It only takes 10 calls to prevent one unnecessary
hospitalization
We can reduce LOS (average 3 days)
We can reduce ICU overutilization We can reduce resource allocation We can reduce hospital admission costs
The pharmacist role for Hazmat
Include poison center in emergency plans Call us for antidote questions
Dose Administration Facilitate procurement of antidotes
Connect us with the incident commander Call in all patients “exposed” so that
surveillance can occur
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NPDS
National Poison Database System
Used by all poison centers Cases uploaded every 8 minutes Can identify clusters of poisonings Used by CDC for toxicosurveillance
Poison Center Chempack policy
During a potential public health emergency or
incident, where CHEMPACK contents might be required, the New Mexico Poison & Drug Information Center will assist the Department of Health by 1) determining whether the CHEMPACK antidotes may be useful given all known facts regarding the incident at the time NMPDIC is contacted 2) rendering a decision to use or not use the CHEMPACK 3) estimating antidote dosing units that will be needed.
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How to ask for help
The on-scene Incident Commander, Emergency
Response Officer, or hospital representative will contact the NMPDIC via 505-272-0064 and will request assistance in determining whether CHEMPACK should be used for a potential chemical/nerve agent incident.
All known information will be communicated to any Poison Information Specialist
The Poison Information Specialist will contact
the NMDOH on-call Epidemiologist Service, who will render a decision about usefulness of the CHEMPACK and will approve its deployment. List of chemical agents that create potential hospital hazmat patients
Mercury Organophosphates/nerve gases Aluminum phosphide Zinc phosphide ATSDR “Managing hazardous materials
incidents: a planning guide for the management of contaminated patients: http://www.atsdr.cdc.gov/MHMI/mhmi_v1_ 2_3.pdf.
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Many Ways to Contact NMPDIC
Emergency
1-800-222-1222
Cell phone issues
505-272-2222 ssmolinske@salud.unm.e
du
http://nmpoisoncenter.unm
.edu/
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