Parentage Verification Development of new ICAR and Interbull - - PowerPoint PPT Presentation

Parentage Verification

Development of new ICAR and Interbull services: GenoEx-PSE and ICAR Accreditation

Outline

Background 1 Interbull Centre 2 GenoEx-PSE 3 ICAR Accreditation 4 Service Users 5 Conclusions and benefits 6

Interbull Centre

Department of Animal Breeding and Genetics Swedish University of Agricultural Sciences Uppsala, Sweden

Interbull Centre

• Operational unit of Interbull – a permanent

sub-committee of the International Committee for Animal Recording (ICAR)

• European Union Reference Laboratory

(EURL) for Zootechnics (Bovine Breeding)

• ISO 9001:2008 certified.

Supporting dairy and beef industry:

• Accurate genetic information on bulls
• Dairy and beef; 35 Countries; Since 1996
• Enabling importers and exporters to select, worldwide,

the best genetics for different countries, environments or breeding goals

• International Genetic and Genomic Evaluations:
• Interbull “MACE”, “GMACE”, “InterGenomics”; Interbeef

Interbull / Interbull Centre

Interbull / Interbull Centre

• Infrastructure and expertise for International Data

Exchange and Quality Assurance:

• Processes
• Standards
• Protocols
• Code or Practice

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Interbull

• Breed associations globally have been manually

sharing microsatellite profiles as a process for maintaining herd book integrity.

• SNP genotypes more accurate than microsatellite

profiles for confirmation of parentage

• International exchange of SNP genotypes for

parentage analysis provides benefit to wide group of ICAR member countries

Parentage Verification

GenoEx-PSE - principles

GENOEX-PSE

• Is a tool to facilitate (not a replacement for national authorities);
• Interbull Centre will not have the right to do parentage

analysis;

• SNP exchange ONLY for parentage analysis;
• Verification, discovery, imputation for subsequent verification
• Currently only cattle: both dairy and beef;
• A voluntary initiative;
• National responsibilities will remain where they are now.

• “Targeted” animals to be routinely uploaded:
• AI sires and their dams
• Foreign-born sires with daughters born in your country
• Parents of animals born by embryo transfer (ET)
• Other special cases as needed

Target Animals

• ICAR has existing accreditation procedures for

laboratories processing DNA into genotypes

• New ICAR accreditation service will be introduced in

conjunction with GenoEx-PSE

• Accreditation for DNA Data Interpretation Centres
• Initial application followed by a accreditation renewal

every two years

• Prerequisite to join GenoEx-PSE

ICAR Accreditation

Service Users

• Interbull Users and ICAR Members:
• Only service users with signed agreement can upload

and download data

• Can only download SNPs in accordance with what they

upload

• Organizations officially in charge of parentage

certification in each of the ICAR member countries, or

• therwise traditionally providing parentage certificate
• Organizations that in their capacity as the official body in

charge of genetic/genomic evaluation services

• ICAR/ISAG accredited laboratories that are under

contract with the organizations identified in 1 or 2 above

Service Users must:

• Upload regularly (at least 3x per year)
• Report conflicts identified via GenoEx-PSE to the

authorised organisation

• Follow ICAR rules, regulations and policies
• GenoEx-PSE rules
• Pass ICAR accreditation for DNA Data Interpretation Centre
• Maintain the accreditation status
• Not use for other purposes than Parentage Analysis
• Not share/exchange data with third party

Service Users; Obligations

Exchange of SNPs – before GenoEx-PSE

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Exchange of SNPs – before GenoEx-PSE

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GenoEx- PSE

National responsibilities will remain where they are now. MULTILATERAL SNP DATA EXCHANGE by establishing a common repository and customer driven access rules:

• Countries with national genomic evaluations would already be

doing Parentage Analysis

• Have genotypes for essentially all dams and AI sires
• Potentially missing genotypes for some sires
• Quicker/smoother transition from use of microsatellite to use of

SNPs

• Optimize customer investments in genotyping by avoiding

duplication

• AI bull owners will have more accurate identity of daughters in

countries importing semen

Concusions and benefits

Thank you.