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P❡r❢♦r♠❛♥❝❡ ♦❢ ❢✉t✉r❡ ♠❡❞✐❝❛❧ ♣r❡❞✐❝t✐♦♥s ❚❤♦♠❛s ❆❧❡①❛♥❞❡r ●❡r❞s ❉❡♣❛rt♠❡♥t ♦❢ ❇✐♦st❛t✐st✐❝s✱ ❯♥✐✈❡rs✐t② ♦❢ ❈♦♣❡♥❤❛❣❡♥✱ ❈♦♣❡♥❤❛❣❡♥✱ ❉❡♥♠❛r❦ ✶✽ ❆♣r✐❧ ✷✵✶✻ ✶ ✴ ✹✽

❖✉t❧✐♥❡ ❈❤❛♣t❡r ■✿ Pr❡❞✐❝t❡❞ r✐s❦ ❈❤❛♣t❡r ■■✿ ❘✐s❦ ♠♦❞❡❧❧✐♥❣ ❈❤❛♣t❡r ■■■✿ Pr❡❞✐❝t✐♦♥ ♣❡r❢♦r♠❛♥❝❡ ❈❤❛♣t❡r ■❱✿ ❉❛t❛ s♣❧✐tt✐♥❣ ❈❤❛♣t❡r ❱✿ ❈♦♠♣❡t✐♥❣ r✐s❦s ❈❤❛♣t❡r ❱■✿ ■♥❝r❡♠❡♥t❛❧ ✈❛❧✉❡ ✷ ✴ ✹✽

❚❤❡ s♦✉r❝❡s ♦❢ ❡rr♦r ✐♥ ❛♣♣❧②✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ❛r❡ ❧❡❣✐♦♥ ❛♥❞ ✐♥❝❧✉❞❡ ❛❧❧ ♦❢ t❤❡ ❢♦❧❧♦✇✐♥❣✿ ❯s✐♥❣ t❤❡ s❛♠❡ s❡t ♦❢ ❞❛t❛ ❜♦t❤ t♦ ❢♦r♠✉❧❛t❡ ❤②♣♦t❤❡s❡s ❛♥❞ t♦ t❡st t❤❡♠✳ ✳ ✳ ✳ ✳ ✳ ✳ ❋❛✐❧✐♥❣ t♦ ✈❛❧✐❞❛t❡ ♠♦❞❡❧s✳ ❇✉t ♣❡r❤❛♣s t❤❡ ♠♦st s❡r✐♦✉s s♦✉r❝❡ ♦❢ ❡rr♦r ❧✐❡s ✐♥ ❧❡tt✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ♠❛❦❡ ❞❡❝✐s✐♦♥s ❢♦r ②♦✉✳ P✳■✳ ●♦♦❞✱ ❈♦♠♠♦♥ ❡rr♦rs ✐♥ ❙t❛t✐st✐❝s✱ ❲✐❧❡② ✸ ✴ ✹✽

❯s✐♥❣ t❤❡ s❛♠❡ s❡t ♦❢ ❞❛t❛ ❜♦t❤ t♦ ❢♦r♠✉❧❛t❡ ❤②♣♦t❤❡s❡s ❛♥❞ t♦ t❡st t❤❡♠✳ ✳ ✳ ✳ ✳ ✳ ✳ ❋❛✐❧✐♥❣ t♦ ✈❛❧✐❞❛t❡ ♠♦❞❡❧s✳ ❇✉t ♣❡r❤❛♣s t❤❡ ♠♦st s❡r✐♦✉s s♦✉r❝❡ ♦❢ ❡rr♦r ❧✐❡s ✐♥ ❧❡tt✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ♠❛❦❡ ❞❡❝✐s✐♦♥s ❢♦r ②♦✉✳ P✳■✳ ●♦♦❞✱ ❈♦♠♠♦♥ ❡rr♦rs ✐♥ ❙t❛t✐st✐❝s✱ ❲✐❧❡② ❚❤❡ s♦✉r❝❡s ♦❢ ❡rr♦r ✐♥ ❛♣♣❧②✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ❛r❡ ❧❡❣✐♦♥ ❛♥❞ ✐♥❝❧✉❞❡ ❛❧❧ ♦❢ t❤❡ ❢♦❧❧♦✇✐♥❣✿ ✸ ✴ ✹✽

❋❛✐❧✐♥❣ t♦ ✈❛❧✐❞❛t❡ ♠♦❞❡❧s✳ ❇✉t ♣❡r❤❛♣s t❤❡ ♠♦st s❡r✐♦✉s s♦✉r❝❡ ♦❢ ❡rr♦r ❧✐❡s ✐♥ ❧❡tt✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ♠❛❦❡ ❞❡❝✐s✐♦♥s ❢♦r ②♦✉✳ P✳■✳ ●♦♦❞✱ ❈♦♠♠♦♥ ❡rr♦rs ✐♥ ❙t❛t✐st✐❝s✱ ❲✐❧❡② ❚❤❡ s♦✉r❝❡s ♦❢ ❡rr♦r ✐♥ ❛♣♣❧②✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ❛r❡ ❧❡❣✐♦♥ ❛♥❞ ✐♥❝❧✉❞❡ ❛❧❧ ♦❢ t❤❡ ❢♦❧❧♦✇✐♥❣✿ ❯s✐♥❣ t❤❡ s❛♠❡ s❡t ♦❢ ❞❛t❛ ❜♦t❤ t♦ ❢♦r♠✉❧❛t❡ ❤②♣♦t❤❡s❡s ❛♥❞ t♦ t❡st t❤❡♠✳ ✳ ✳ ✳ ✳ ✳ ✳ ✸ ✴ ✹✽

❇✉t ♣❡r❤❛♣s t❤❡ ♠♦st s❡r✐♦✉s s♦✉r❝❡ ♦❢ ❡rr♦r ❧✐❡s ✐♥ ❧❡tt✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ♠❛❦❡ ❞❡❝✐s✐♦♥s ❢♦r ②♦✉✳ P✳■✳ ●♦♦❞✱ ❈♦♠♠♦♥ ❡rr♦rs ✐♥ ❙t❛t✐st✐❝s✱ ❲✐❧❡② ❚❤❡ s♦✉r❝❡s ♦❢ ❡rr♦r ✐♥ ❛♣♣❧②✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ❛r❡ ❧❡❣✐♦♥ ❛♥❞ ✐♥❝❧✉❞❡ ❛❧❧ ♦❢ t❤❡ ❢♦❧❧♦✇✐♥❣✿ ❯s✐♥❣ t❤❡ s❛♠❡ s❡t ♦❢ ❞❛t❛ ❜♦t❤ t♦ ❢♦r♠✉❧❛t❡ ❤②♣♦t❤❡s❡s ❛♥❞ t♦ t❡st t❤❡♠✳ ✳ ✳ ✳ ✳ ✳ ✳ ❋❛✐❧✐♥❣ t♦ ✈❛❧✐❞❛t❡ ♠♦❞❡❧s✳ ✸ ✴ ✹✽

P✳■✳ ●♦♦❞✱ ❈♦♠♠♦♥ ❡rr♦rs ✐♥ ❙t❛t✐st✐❝s✱ ❲✐❧❡② ❚❤❡ s♦✉r❝❡s ♦❢ ❡rr♦r ✐♥ ❛♣♣❧②✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ❛r❡ ❧❡❣✐♦♥ ❛♥❞ ✐♥❝❧✉❞❡ ❛❧❧ ♦❢ t❤❡ ❢♦❧❧♦✇✐♥❣✿ ❯s✐♥❣ t❤❡ s❛♠❡ s❡t ♦❢ ❞❛t❛ ❜♦t❤ t♦ ❢♦r♠✉❧❛t❡ ❤②♣♦t❤❡s❡s ❛♥❞ t♦ t❡st t❤❡♠✳ ✳ ✳ ✳ ✳ ✳ ✳ ❋❛✐❧✐♥❣ t♦ ✈❛❧✐❞❛t❡ ♠♦❞❡❧s✳ ❇✉t ♣❡r❤❛♣s t❤❡ ♠♦st s❡r✐♦✉s s♦✉r❝❡ ♦❢ ❡rr♦r ❧✐❡s ✐♥ ❧❡tt✐♥❣ st❛t✐st✐❝❛❧ ♣r♦❝❡❞✉r❡s ♠❛❦❡ ❞❡❝✐s✐♦♥s ❢♦r ②♦✉✳ ✸ ✴ ✹✽

❚❛✐❧♦r❡❞ ♣r♦❜❛❜✐❧✐t② ▼✐❝❤❛❡❧ ❑❛tt❛♥ ✭❝♦♠♣✉t❡r s❝✐❡♥t✐st✱ ♣❛t✐❡♥t✮✿ ❲❤❡♥ ■ ✇❛s ❞✐❛❣♥♦s❡❞ ✇✐t❤ ❧②♠♣❤♦♠❛ ✶✶ ②❡❛rs ❛❣♦✱ ■ ✇❛s ❡❛❣❡r t♦ ❧❡❛r♥ ♠② ♣r♦❣♥♦s✐s✳ ✶ ■ r❡❛❧❧② ✇❛♥t❡❞ ❛ ♣r❡❞✐❝t❡❞ ♣r♦❜❛❜✐❧✐t② ♦❢ s✉r✈✐✈❛❧ ❛♥❞ ❞✐❞♥✬t s♣❡❝✐✜❝❛❧❧② ❝❛r❡ ✇❤❛t t❤❡ ♣r♦❣♥♦st✐❝ ❢❛❝t♦rs ✇❡r❡✱ ✇❤❛t ♠② r❡❧❛t✐✈❡ r✐s❦ ♠✐❣❤t ❜❡✱ ♦r ✐♥ ✇❤❛t r✐s❦ ❣r♦✉♣ ■ ❜❡❧♦♥❣❡❞✳ ❲❡ s❤♦✉❧❞ ♣r♦❞✉❝❡ ✐♥❝r❡❛s✐♥❣❧② ❛❝❝✉r❛t❡ ♣r❡❞✐❝t✐♦♥ ♠♦❞❡❧s ❜② ✐♥❝r❡❛s✐♥❣ s❛♠♣❧❡ s✐③❡s✱ ❛❞❞✐♥❣ ✐♥❢♦r♠❛t✐✈❡ ♠❛r❦❡rs✱ ❛♥❞ ❛♣♣❧②✐♥❣ ♠♦r❡ s♦♣❤✐st✐❝❛t❡❞ ♠♦❞❡❧✐♥❣ ❛♣♣r♦❛❝❤❡s✳ ✶ ❙t❛t✐st✐❝❛❧ ♣r❡❞✐❝t✐♦♥ ♠♦❞❡❧s✱ ❛rt✐✜❝✐❛❧ ♥❡✉r❛❧ ♥❡t✇♦r❦s✱ ❛♥❞ t❤❡ s♦♣❤✐s♠ ■ ❛♠ ❛ ♣❛t✐❡♥t✱ ♥♦t ❛ st❛t✐st✐❝✳ ❏♦✉r♥❛❧ ♦❢ ❈❧✐♥✐❝❛❧ ❖♥❝♦❧♦❣②✱ ✷✵✿✽✽✺✲✽✽✼✱ ✷✵✵✷ ✹ ✴ ✹✽

❈❤❛♣t❡r ■✿ Pr❡❞✐❝t❡❞ r✐s❦ ✺ ✴ ✹✽

Pr❡❞✐❝t✐♦♥s ✐♥ s✉r✈✐✈❛❧ ❛♥❛❧②s✐s Pr❡❞✐❝t✐♥❣ ❡✈❡♥t t✐♠❡s ✐s ♥♦t ♣♦ss✐❜❧❡ ❛❧♠♦st ❛❧✇❛②s✱ ♣❛rt❧② ❜❡❝❛✉s❡ ♦❢ t♦♦ ♠✉❝❤ ✉♥❝❡rt❛✐♥t②✱ ♣❛rt❧② ❜❡❝❛✉s❡ ♦❢ ❧✐♠✐t❡❞ ❢♦❧❧♦✇✲✉♣✳ ■♥st❡❛❞✿ ◮ Pr❡❞✐❝t ♣❡rs♦♥❛❧✐③❡❞ ❛❜s♦❧✉t❡ r✐s❦ t❤❛t t❤❡ ❡✈❡♥t ♦❝❝✉rs ❜❡t✇❡❡♥ t✐♠❡ ♦r✐❣✐♥ ❛♥❞ t✐♠❡ ❤♦r✐③♦♥ ◮ ❊✳❣✳✱ r✐s❦ ♦❢ ❝❛♥❝❡r r❡❝✉rr❡♥❝❡ ✇✐t❤✐♥ ✺ ②❡❛rs ❛❢t❡r s✉r❣❡r② P❡rs♦♥❛❧✐③❡❞ ♣r♦❜❛❜✐❧✐st✐❝ ♣r❡❞✐❝t✐♦♥s ❛r❡ ✐♥t✉✐t✐✈❡ ❢♦r t❤❡ ♣❛t✐❡♥t ❜✉t ✉s✉❛❧❧② r❡q✉✐r❡ ❛ ❝♦♠♣❧❡① ♠♦❞❡❧ ❜❡❝❛✉s❡ ♦❢ ✭r✐❣❤t✮ ❝❡♥s♦r✐♥❣✳ ✻ ✴ ✹✽

❚❤❡ r♦❧❡ ♦❢ t✐♠❡ Prediction model timeline Time point at which Time point patient is provided attached to the prediction with prediction followup baseline Origin (time 0) Horizon (time t) Lost to followup, or (right) censored, means that patient was not followed until horizon time t. ❯♥t✐❧ t✐♠❡ t✱ t❤r❡❡ t❤✐♥❣s ❝❛♥ ❤❛♣♣❡♥✿ ◮ ♣❛t✐❡♥t ✐s ❡✈❡♥t✲❢r❡❡ ◮ t❤❡ ❡✈❡♥t ♦❢ ✐♥t❡r❡st ❤❛s ♦❝❝✉rr❡❞ ◮ ❛ ❝♦♠♣❡t✐♥❣ ❡✈❡♥t ❤❛s ♦❝❝✉rr❡❞ ✼ ✴ ✹✽

❚❤❡ ♠❛❦✐♥❣ ♦❢ ❛ st❛t✐st✐❝❛❧ r✐s❦ ♣r❡❞✐❝t✐♦♥ ♠♦❞❡❧ ✶✳ ❙♣❡❝✐❢② ♠♦❞❡❧❧✐♥❣ str❛t❡❣② ✐♥❝❧✉❞✐♥❣ ❞❛t❛ ❞❡♣❡♥❞❡♥t st❡♣s s✉❝❤ ❛s s②st❡♠❛t✐❝ s❝r❡❡♥✐♥❣ ♦❢ ♣♦t❡♥t✐❛❧ r✐s❦ ❢❛❝t♦rs✱ ❝❤♦✐❝❡ ♦❢ ❧✐♥❦ ❢✉♥❝t✐♦♥✱ ♣❡♥❛❧t② ❛♥❞ ♦t❤❡r ❤②♣❡r✲♣❛r❛♠❡t❡rs✳ ✷✳ ❆♣♣❧② ♠♦❞❡❧✐♥❣ str❛t❡❣② t♦ ❧❡❛r♥✐♥❣ ❞❛t❛ s❡t ❛♥❞ ♦❜t❛✐♥ ♠♦❞❡❧✿ ˆ π ( t , X i ) ≈ ❘✐s❦ ♦❢ ❡✈❡♥t ❜❡❢♦r❡ t ❢♦r ♥❡✇ s✉❜❥❡❝t X i ✸✳ ❱❛❧✐❞❛t❡ ♠♦❞❡❧✭✐♥❣ str❛t❡❣②✮ ✐♥t❡r♥❛❧❧② ✈✐❛ ❝r♦ss✈❛❧✐❞❛t✐♦♥ ✹✳ ❱❛❧✐❞❛t❡ ♠♦❞❡❧ ❡①t❡r♥❛❧❧② ✉s✐♥❣ ✐♥❞❡♣❡♥❞❡♥t ✈❛❧✐❞❛t✐♦♥ ❞❛t❛ ✽ ✴ ✹✽