SLIDE 7 12/3/2016 7 Management of Bilateral LSCD Comparative Visual Outcomes
- Keratolimbal allografts
- Post-op VA > 20/200 in 44% of eyes1,2
- COMET
- Pre-op VA > 20/200 in 0% of eyes
- Post-op VA > 20/200 in 27% of eyes at 3-34 months3
- Boston keratoprosthesis
- Pre-op VA > 20/200 in 7% of eyes
- Post-op VA > 20/200 in 77%, 88% and 86% of eyes
at 1, 3 and 5 years
1. Shi W, Gao H, Wang T, et al. Combined penetrating keratoplasty and keratolimbalallograft transplantation in comparison with corneoscleraltransplantation in the treatment of severe eye burns. Clin Experiment Ophthalmol 2008;36:501–7.
- 2. Solomon A, Ellies P, Anderson DF, et al. Long-term outcome of keratolimbal allograft with or without penetrating keratoplasty for total limbalstem cell deficiency. Ophthalmology 2002;109:1159–66.
- 3. Inatomi T, Nakamura T, Koizumi N, Sotozono C, Yokoi N, Kinoshita S. Midterm results on ocular surface reconstruction using cultivated autologous oral mucosal epithelialtransplantation. Am J
- Ophthalmol. 2006;141:267-275.
Management of LSCD Boston Keratoprosthesis Retention
Cumulative Proportion of Retention
0.0 0.2 0.4 0.6 0.8 1.0
Length of Follow-up (Months)
24 48 72 96 120 LSCD Non-LSCD
Management of LSCD Boston Kpro vs KLAL Retention vs Survival
Solomon A, Ellies P, Anderson DF, Touhami A, Grueterich M, Espana EM, Ti SE, Goto E, Feuer WJ, Tseng SC. Long-term outcome of keratolimbal allograft with
- r without penetrating keratoplasty for total limbal stem cell deficiency.Ophthalmology. 2002;109:1159-66.
Cumulative Proportion of Retention
0.0 0.2 0.4 0.6 0.8 1.0
Length of Follow-up (Months)
24 48 72 96 120 LSCD Non-LSCD
Management of LSCD Boston Kpro vs KLAL Retention vs Survival
Cumulative Proportion of Retention
0.0 0.2 0.4 0.6 0.8 1.0
Length of Follow-up (Months)
24 48 72 96 120 LSCD Non-LSCD Ilari L, Daya SM. Long-term outcomes of keratolimbal allograft for the treatment of severe ocular surface disorders. Ophthalmology. 2002;109:1278-84.
