NOW! Industrial Development Corporation, Select Greater - - PowerPoint PPT Presentation

By

BANU ONARAL, PHD

SENIOR ADVISOR – STRATEGIC PARTNERSHIPS TEKNOPARK ISTANBUL, TURKEY

&

• H. H. SUN PROFESSOR AND DIRECTOR

SCHOOL OF BIOMEDICAL ENGINEERING, SCIENCE AND HEALTH SYSTEMS DREXEL UNIVERSITY PHILADELPHIA PA, USA

IP MANAGEMENT @ UNIVERSITIES…30-31 OCTOBER’14 Boğaziçi University, Istanbul, Turkey

“UNIVERSITY-INDUSTRY PARTNERSHIPS: SUCCESS STORIES”

COULTER-DREXEL TRANSLATIONAL RESEARCH PARTNERSHIP A

MODEL TO COMMERCIALIZE ACADEMIC IP

AND

DAVOOD TASHAYYOD

COULTER PROJECT DIRECTOR

Unmet clinical need Assemble all those who bring value to commercialization

– Academics bring scientific and technological goods – Industry provides commercialization means – Shared mission implemented through concrete projects

• Entrepreneurs, lawyers, business and economic development

professionals and investors embedded in the academic trenches Project management discipline is a MUST  One size does not fit all – local rules of engagement

FUSING ACADEMIC AND BUSINESS CULTURES

TO COMMERCIALIZE UNIVERSITY RESEARCH

DIMENSIONS OF TRANSLATIONAL RESEARCH

Road map to accelerate commercialization of university innovation

• De-risking process that brings university biomedical innovations to a critical endpoint
• Compressed timelines and laser focus effort
• Attract follow-on funding from ‘professional investors’ or industry: SUCCESS METRICS

Project Management

• Office of Coulter Project Director
• Deliverables, Milestones & Budgets

Due Diligence

• Market Research – Go/No Go
• IP – Patentability & Freedom to Operate
• Regulatory Pathway
• Reimbursement

Diligence is the mother of good luck

Benjamin Franklin (Poor Richard's Almanack, 1736)

Joined in 2011  Columbia University  Johns Hopkins University  University of Louisville  University of Missouri  University of Pittsburgh  University of Southern California

“Science serves humanity”

…Address unmet needs in healthcare Starting in 2006

• Boston University
• Case Western Reserve University
• Drexel University*
• Duke University
• Georgia Technology Institute
• University of Michigan
• Stanford University
• University of Virginia
• University of Washington
• University of Wisconsin

… that fuses academic and business cultures

A TRANSFORMATIVE PARTNERSHIP A NATIONAL BEST PRACTICE

FRAMEWORK

Working Hypothesis

 An industry like approach for product development

• Can be established in the universities
• Will accelerate the translation of innovation to market place

Investment Guidelines

 Develop products for the improved management of unmet or poorly met clinical needs:

• For any significant medical problems or diseases
• Demonstrable clinical impact and improve patient lives
• Invasive and non-invasive medical devices
• Diagnostic or therapeutic technologies
• Clinical software
• Hybrid hardware-software systems



Drexel Partners

Medicine; Public Health; Nursing and Health Professions; Arts and Science; Engineering; Information Science; Media Arts and Design; Business and Law



Economic Development Agencies & Trade Organizations

Ben Franklin Technology Partners, BioAdvance, PA Bio, Philadelphia Industrial Development Corporation, Select Greater Philadelphia, University City Science Center…



Corporate Partners

Exponent, Integra Life Sciences, Shire, Johnson and Johnson…



Institutional Partners

Children’s Hospital of Philadelphia (CHOP); Fox Chase Cancer Research Institute; Good Shepherd Rehabilitation Network; Inglis Foundation; Lankenau Hospital; Monell Chemical Senses Center; Shriners Hospitals for Children; Thomas Jefferson University; University of Pennsylvania; Wistar Institute…



Business Development, Legal and Investment Partners… Alumni and Friends…

…State of Pennsylvania and Federal Agencies

RETHINKING PHILADELPHIA ✓ REINVENTING PHILADELPHIA ✓

ACTION PHILADELPHIA

NOW!

…WHERE IT ALL BEGAN

OUR EXPANDING COMMERCIALIZATION COMMUNITY

Regional Innovation Partners

WHY DREXEL?

• Misssion & Mandate: Relevance to the clinic and the industry
• Translational research track record
• Multi-disciplinary and multi-institutional culture
• end to end solutions
• Committed to engagement with industry and investment community
• Access to a far-reaching network of innovation partners

Global Innovation Partners Turkey: Regional health innovtion

movements: INOVIZ, INOVAnkara, INOVITA…

Teknopark Istanbul, OSTIM, DEpark, EGE Teknopark…

China: Shanghai Jiao Tong University – Med-X

Research Institute, Dual PhD; Drexel - Shanghai Advanced Research Institute (SARI)

Israel: Hebrew University - Institute for Drug

Research; Hadassah Medical Center; Yissum Technology Transfer; Haifa University – Edmond

• J. Safra Brain Research Center

+

IMPACT

INVEST  IMPLEMENT  LEVERAGE  OUTCOMES

NATIONAL COULTER TRANSLATIONAL RESEARCH - PARTNERSHIP OUTCOMES 6TH YEAR AUDITED RESULTS (AS OF DECEMBER 31, 2012) Number of projects US$ in million

Funded projects

~250 56

VC funding

40 352.2

Repeat VC funding

13 119.4

New VC funding

12 79.9

Industry

29

Success rate to license to VC/A funded startup or Industry

27.6%

Projects in clinical trials

11

Partial reporting

Projects in the market

9

Partial reporting

ROI

~7X

Commercialization Outcomes

• 31 Technologies supported and 10 Technologies seeded
• Patents: Invention disclosures 57; Patent applications 91; Issued patents 19
• 12 Technologies licensed (2 Technologies licensed to regional companies - 2

Drexel students hired by regional licensees)

• $31M of follow-on funding raised

Community Impact

• Industry and Corporate Innovation Partnerships
• Regional, National and Global Innovation Partnerships

   DREXEL INNOVATION NEIGHBORHOOD

IMPACT INVEST  IMPLEMENT  LEVERAGE 

OUTCOMES 2006 - 11

COULTER-DREXEL TRANSLATIONAL RESEARCH PARTNERSHIP - LICENSED TECHNOLOGIES

• VEUSim: A Virtual Endovaginal Ultrasound Simulator for Physician Training
• LCL Grafts: Innovative Small Caliber Vascular Grafts for Coronary Bypass
• Optical Diagnosis and Treatment Optimization in Chronic Diabetic Wounds: A

Pilot Clinical Study

• Living Tissue Sterilization by the Dielectric Barrier Discharge Plasma
• Cardiac Biomarker Detection using Q-DOT Immunoassay QLIDA

COULTER-DREXEL TRANSLATIONAL RESEARCH PARTNERSHIP - LICENSED TECHNOLOGIES

• Bioactive Alimentary Protein-Based Scaffolds (APS) for Wound Healing
• Electronic Blood Pressure Wristwatch
• Portable Breast Cancer Screening by Elasticity and Mobility Measurement to

Locate Tumor Malignancy

• Syk Kinase as a Biomarker of Skin UV Damage and Photocarcinogenesis
• Biomimetic Aggrecan Injection

• Real-time Seizure Detection and Control System using Our Patented

Ceramic-base Multisite Electrode

• Functional Near-infrared Spectroscopy as a Monitor for Depth of

Anesthesia

• Fast Plasma-assisted Hand Disinfection or Sterilization System
• Quantum Dots for interaoperative Margin Determination during Breast

Cancer Surgery

• Non-Invasive Hand-Held Brain Edema Monitoring System

COULTER-DREXEL TRANSLATIONAL RESEARCH PARTNERSHIP - LICENSED TECHNOLOGIES

• Maternity "Smart Fabric Bellyband" to Monitor Uterine Activity and Assess Fetal

Well-being

• Ultrasound for Localizing Endotracheal Tubes (ETTs) in Neonates
• Diagnosis of Tissue Damage (Bed Sores) from Micron to Centimeter Depths Using

Non-Contact Near Infrared

• Nanoscale Thin Coatings for Neural Prostheses (Seed)
• Functional Near-infrared Spectroscopy for Assessment in Schizophrenia (Seed)
• Injectable Hydrogel Loaded with Particles Releasing Minocycline for Spinal Cord

Repair (Seed)

• Plasma-activated Antimicrobial Wound Dressing (Seed)

COULTER-DREXEL TRANSLATIONAL RESEARCH PARTNERSHIP - LICENSED TECHNOLOGIES

CHRONOLOGICAL PERSPECTIVE OF TRANSLATIONAL RESEARCH AT DREXEL UNIVERSITY

• Biomedical Engineering and Science Institute founded, 1960
• Reorganized as the School of Biomedical Engineering, 1998 – New mission: Move

discoveries to healthcare

• Alumni participation - First Entrepreneurship in Biomedical Engineering course

taught, 2000

• Outreach to university and regional partners (other universities, research

institutes, development agencies), 2001

• Technology Transfer Office established – One licensing professional, 2004
• Coulter Translational Partnership Program announced, 2004
• Coulter Translational Partnership Competition (80 Universities), 2005
• Drexel wins the Coulter TP award together with 9 other Universities (Conditional
• n recruitment of additional licensing professionals), 2006
• Rob Loring, an Alumnus, serves as the first Coulter Project Director
• Coulter Endowment awarded to Drexel and 4 other schools, 2011

HOW TO GET INVOLVED

Collaborative Research Programs Oversight Committee Service

• Advise & Mentorship
• Consultant / Business Advisor
• Out-licensing
• Option Agreement
• License Agreement
• Sponsored Research Agreement

INNOVATION NEIGHBORHOOD

A mixed use - multifunction neighborhood for innovation, technology, globalization, and economic development that:

• Brings educational institutions together with businesses, entrepreneurs, and government

leaders

• Leverages our Coulter program as a model for translational research partnerships
• Starts new companies and to foster economic growth and development (Drexel Ventures)
• Intersection of Engineering, Media Arts & Design (ExCITe Center)

 Pioneer in cooperative education (co-op) since 1919  One of the largest co-op programs in the world  Enables undergraduate and graduate students to balance classroom theory with practical, hands-on experience  Alternating six months of classes with six months employment  Over 5000 students in more than 75 majors participate in the co-op program annually  Approximately 1500 employers  From start-ups to multi-national corporations!

STEINBRIGHT CAREER DEVELOPMENT CENTER

HIRING A DREXEL CO-OP STUDENT?

RECENT CELEBRATIONS

INDUSTRY INNOVATION PARTNERSHIP

April 10, 2013 @ Drexel University

GLOBAL INNOVATION PARTNERSHIP FORUM &

Nov 20–22, 2013 @ Drexel University Davood Tashayyod dt97@drexel.edu +1 (202) 368-1216

THANK YOU!

Banu Onaral banu.onaral@Drexel.edu +1 (215) 776 2194 GLOBAL INNOVATION PARTNERSHIP FORUM’12