New Methods in Predictive Analytics Using Big Data to Develop - - PowerPoint PPT Presentation

▶
new methods in predictive analytics using
SMART_READER_LITE
LIVE PREVIEW

New Methods in Predictive Analytics Using Big Data to Develop - - PowerPoint PPT Presentation

Oct 22, 2022 654 likes •712 views

New Methods in Predictive Analytics Using Big Data to Develop Personalized Treatment Models for Anxiety and Mood Disorders Ronald C. Kessler, Ph.D. McNeil Family Professor of Health Care Policy Harvard Medical School Presentation at Academy

slide-1
SLIDE 1

New Methods in Predictive Analytics Using Big Data to Develop Personalized Treatment Models for Anxiety and Mood Disorders

Ronald C. Kessler, Ph.D. McNeil Family Professor of Health Care Policy Harvard Medical School

Presentation at Academy Health in the session “Personalized Medicine Ain’t Just Genomics: Using Predictive Analytics to Deliver Patient-Centered Care and Population Health” June 28, 2016

1

slide-2
SLIDE 2
  • Many significant predictors
  • Few of these predictors are available in EMRs
  • Existing research is based on small clinical trial samples
  • Comparisons typically involve active comparison of 2 treatment options

(e.g., psychotherapy vs. medication)

Previous Research on Predictors of Differential Anxiety-Depression Treatment Response

2

slide-3
SLIDE 3
  • Feature selection
  • Web-based self-report
  • EMR data
  • The requirement for a large sample
  • Double-robust observational data vs. controlled trials
  • Non-random selection into type of treatment
  • Non-random loss to follow-up
  • Heterogeneity of treatment response
  • Development of a distinct model for each type of treatment
  • Cross-validated individual-level outcome comparison across treatments
  • Estimation
  • Ensemble machine learning

Challenges in Model-Building

3

slide-4
SLIDE 4
  • Demonstrating effectiveness
  • Pragmatic trials
  • Level of entry
  • Imposing on busy clinical schedules
  • Best practices quality assurance
  • Clinical decision support
  • Primary care & collaborative care support
  • Specialty care support

Challenges in Implementation

4

slide-5
SLIDE 5

Contact Ronald C. Kessler, Ph.D. kessler@hcp.med.harvard.edu Background Material Kessler, R.C., van Loo, H.M., Wardenaar, K.J., Bossarte, R.M., Brenner, L.A., Ebert, D.D., de Jonge, P., Nierenberg, A.A., Rosellini, A.J., Sampson, N.A., Schoevers, R.A., Wilcox, M.A., Zaslavsky, A.M. (2016). Using patient self-reports to study heterogeneity of treatment effects in major depressive disorder. Epidemiology and Psychiatric Sciences, [Epub ahead of print], 1-15. PMID: 26810628

5