NDAL`s Research Activities and the State of Biological Research in - - PowerPoint PPT Presentation
NDAL`s Research Activities and the State of Biological Research in Turkey A. Nazl Baak Boazii University Department of Molecular Biology and Genetics Neurodegeneration Research Laboratory Outline Part I Research Interests of
Boğaziçi University Department of Molecular Biology and Genetics Neurodegeneration Research Laboratory
– established at Boğaziçi University in 2005 – by Suna and Inan Kıraç Foundation
– education, – health care – culture and arts
field of health sciences, between an academic institution and an NGO in Turkey
– enhance biomedical research and – specifically neurosciences in Turkey
– NDAL is the only center in Turkey offering routine molecular diagnosis in several neurological disorders
SCA 30% FRDA 17% HD 15% PD 13% ALS 9% DM 9% AD 5% SBMA 1% DRPLA 1%
– expanding the scope of our research to include functional studies
– aiming to understand the mechanisms leading to neurodegenerative processes
Application of bioinformatics and systems biology to human disease Understanding the biology of brain tumors Gaining insights into ALS from genetics/genomics Corticospinal MN development and repair mechanisms Accurate animal models
neurodegenerative disease Functional studies on alsin
– next generation genomic technologies – e.g. exomic and whole-genome sequencing
Undefined SOD1 ANG TDP-43 FUS Other genes 70%
20% 1% 4% 4% 1%
SOD1-D90A
– mutations of alsin give rise to juvenile ALS as well as other neuromuscular diseases
Gerards R., et al., 2004
– homologous recombination
O’Keefe L. V. et al., 2007
development, differentiation and repair
– candidate genes playing a role in the development of CSMN
– temporal analysis of the expression of cand genes in tissue – knock-out mice models of cand genes – in vivo cell labelling – fluorescent cell isolation
– activation of progenitors in the adult cortex to develop into CSMNs (controlled neurogenesis)
neurodegenerative and mental disorders
– GWAS: SNP genotyping in sporadic ALS
– converted into a TR state univ in 1971
universities in Turkey
– well known for its outstanding education at undergraduate and graduate levels – medium of instruction is in english
richer scientific environment cutting-edge technologies
intense networking, collaborations with advanced centers
to increase the critical mass of scientists high chances of support from European Funds large number of potential young scientists excellent theoretical education qualified undergrad and grad students
– hands-on training – state-of-the-art laboratory equipment – well-trained technical personnel
A state of the art and internationally competitive research university with a strong infrastructure!
Friedrich Miescher Lab, 1868
Broad Institute, MIT-Harvard, 2010
We are ready to assist DTU during its transition period…
Istanbul, 2007
Stem Cells, , RNAi and Neurode dege generation
Istanbul, 2009