MOBC NIAAA UPDATE Brett Hagman, Ph.D. Raye Litten, Ph.D. Division of Treatment and Recovery Research, NIAAA 14 th Annual RSA Satellite Session on Mechanisms of Behavior Change: June 16th, 2018
Topics • Recent Accomplishments • New Directions for MOBC NIAAA Grant Portfolio • MOBC funding announcements • A Few Housekeeping Items
Welcome Dr. Raye Litten as Acting Director to the Division of Treatment and Recovery Research!
Recent Accomplishments • DTRR continues to actively maintain MOBC research portfolio • Collaboration with NIH Science of Behavior Change Common Fund • Funded N = 17 out of 32 (50%) PAR FOA – R01, R21, and R03 • Now expired • Continue to co-sponsor MOBC satellite meeting – funded by U13 conference grant • Reviewing ways to continue U13 funding • Published special MOBC sub-section in Journal of Studies on Alcohol and Drugs
Shifting Directions for MOBC Portfolio I. Understanding Processes of Recovery (NEW) II. Intersection of Moderation-Mediation and Personalized Medicine III. Advancing Research Methods IV. Defining, Training and Disseminating MOBC Best Practices (NEW)
New MOBC Direction: Understanding Processes of Recovery • Evaluate the nature and timing of relapse episodes using advanced data collection methods (e.g., Ecological Momentary Assessment) and data analytic techniques (e.g., Dynamic Systems Modeling) • Conduct studies that seek to identify and evaluate specific mechanisms that underlie how mutual help groups and/or continuing care/extended AUD treatments aid in recovery • Support basic neurobiological and behavioral research to identify the factors that facilitate or prevent relapse episodes, and promote resilience
Shifting MOBC Directions: Intersection of Moderated-Mediation and Personalized Medicine • Identify alcohol-related phenotypes and understand how they respond differently to AUD treatments. Evaluate moderated-mediated pathways among these phenotypes • Use dynamic and person-centered statistical modeling approaches to evaluate heterogeneity among MOBC that impact alcohol use behavior within specific AUD treatments and/or targets of relapse risk • Enhance translational research methods by identifying potential neurobiological, cognitive or genetic processes that may act as potential mechanisms of therapeutic change and AUD behavioral treatment outcome
Shifting MOBC Directions: Advancing Research Methods • Incorporate the use of advanced statistical procedures or new methods such as computational or mathematical modeling (e.g., dynamic systems modeling) to understand how fluctuations in specific mechanisms of change interact among individuals, their social environments and treatment outcomes • Understand how to leverage greater use of technology (e.g., computers) to enhance outreach of empirically-supported alcohol behavioral treatments among harder to reach populations • To monitor daily or in real time MOBC that lead to relapse or sustained behavior change and determine how they vary among AUD individuals. This includes using state of the art methodologies, such as the Ecological Momentary Assessment to identify changes in behavior and/or physiological parameters
New MOBC Direction: Dissemination and Training on MOBC Best Practices • Move towards developing MOBC (e.g., best practices) theoretical models based on empirical evidence and consensus in the field – test the models • Further enhance a current empirically-supported behavioral treatment or develop a novel behavioral treatment based on current MOBC empirical evidence • Focus on enhancing training of clinicians and addiction specialists on adopting MOBC best practices – enhance diversity training efforts • Enhance diversity efforts by evaluating how established MOBC within an empirically-supported AUD treatment operate within understudied and vulnerable populations
Funding Opportunities ….
Program Announcements Alcohol Use Disorders: Treatment, Services, and Recovery Research Research Domain #2: Behavioral Therapies and Mechanisms of Behavior Change • R01: PA-18-194 ( https://grants.nih.gov/grants/guide/pa-files/PA-18-194.html) • R21: PA-18-202 ( https://grants.nih.gov/grants/guide/pa-files/PA-18-202.html) • R03: PA-18-201 (https://grants.nih.gov/grants/guide/pa-files/PA-18-201.html) Announcement will expire in September, if so, use the following Parent Announcement: • R01: PA-18-484 (https://grants.nih.gov/grants/guide/pa-files/PA-18-484.html) • R01: PA-18-345 (https://grants.nih.gov/grants/guide/pa-files/PA-18-345.html) • R21: PA-18-489 (https://grants.nih.gov/grants/guide/pa-files/PA-18-489.html) • R21: PA-18-344 (https://grants.nih.gov/grants/guide/pa-files/PA-18-344.html)
Other Program Announcements Understanding Processes of Recovery in the Treatment of Alcohol Use Disorders (Clinical Trial Optional) • R01: PA-18-285 (https://grants.nih.gov/grants/guide/pa-files/PA-17-285.html) • R21: PA-18-284 (https://grants.nih.gov/grants/guide/pa-files/PA-17-284.html) Goal of FOA: The purpose of this FOA is encourage applications that seek to examine processes of recovery and relapse in the treatment of Alcohol Use Disorder
Other Program Announcements Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R01 Clinical Trial Optional) • R01: PA-18-722 (https://grants.nih.gov/grants/guide/pa-files/PA-18-722.html) • R21: PA-18-723 (https://grants.nih.gov/grants/guide/pa-files/PA-18-723.html) • MOBC language in PA: “ NIAAA is also interested in alcohol treatment research focused on understanding the mechanisms that underlie adherence to engaging in and maintenance of behavior change within our empirically-supported alcohol behavioral treatments that target heavy and problematic alcohol use”
NOT-AA-18-009: Notice of Data-Sharing Policy for Human Subjects Grants Research Funded by the National Institute on Alcohol Abuse and Alcoholism The purpose of this notice is to inform prospective applicants responding to the current NIAAA-Funding Opportunity Announcements (FOAs) of a new policy whereby the National Institute on Alcohol Abuse and Alcoholism (NIAAA) will expect investigators and their institutions to provide basic plans for submitting grant-related human subjects data to a NIAAA-sponsored data repository, as outlined in this Notice . These plans should be included in the Data Sharing Plan located in the Resource Sharing Plan section of grant applications. This applies to all grant applications (new and resubmitted) that include human subject research, except Fellowship (F), Training (T), Small Business (SBIR/STTR), and Education (R25) grants. For additional information, please contact Dr. Daniel Falk (falkde@mail.nih.gov).
Additional Housekeeping Items • Please send a concept paper (outlining specific aims, hypotheses and provide description of integrating theory) via email for feedback • Remember, we have new clinical trial guidelines that have been implemented – grants are required to have a clinical trial dissemination plan • NIAAA Data Repository – session guidance on Tuesday with Dr. Trish Powell • NIAAA is moving to a new office building (July 6 th ) - expect some slight delay in communication • All yearly grant progress reports are due on time – grants management needs your help on this
Recap • NIAAA remains committed to MOBC research • Encouraging new directions for MOBC research in recovery, personalized medicine and dissemination • Take advantage of our FOAs – keep those applications coming! • Focus on INNOVATION, IMPACT and STRONGER THEORETICAL MODEL DEVELOPMENT • Funding support available from NIAAA
Helpful Links and References https://www.nih.gov/about-nih/what-we-do/nih-turning-discovery-intohealth/personalized-medicine (Information on NIH Personalized Medicine Initiative) https://directorsblog.nih.gov/tag/personalized-medicine/ (Dr. Collin’s blog on Personalized Medicine) https://allofus.nih.gov/news-events-and-media/news/personalized-medicine-time-one-person-trials https://www.niaaa.nih.gov/dtrr (NIAAA DTRR Program Director and staff page) https://grants.nih.gov/policy/clinical-trials/reporting/index.htm (New NIH clinical trial guidelines)
Thank You For more information, please contact: Brett Hagman, Ph.D. NIAAA brett.hagman@nih.gov 301-443-0638
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