MOBC NIAAA UPDATE Brett Hagman, Ph.D. Raye Litten, Ph.D. Division - - PowerPoint PPT Presentation

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MOBC NIAAA UPDATE Brett Hagman, Ph.D. Raye Litten, Ph.D. Division - - PowerPoint PPT Presentation

Nov 17, 2022 17 likes •200 views

MOBC NIAAA UPDATE Brett Hagman, Ph.D. Raye Litten, Ph.D. Division of Treatment and Recovery Research, NIAAA 14 th Annual RSA Satellite Session on Mechanisms of Behavior Change: June 16th, 2018 Topics Recent Accomplishments New

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MOBC NIAAA UPDATE

Brett Hagman, Ph.D. Raye Litten, Ph.D. Division of Treatment and Recovery Research, NIAAA

14th Annual RSA Satellite Session on Mechanisms of Behavior Change: June 16th, 2018

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  • Recent Accomplishments
  • New Directions for MOBC NIAAA Grant

Portfolio

  • MOBC funding announcements
  • A Few Housekeeping Items

Topics

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Welcome Dr. Raye Litten as Acting Director to the Division of Treatment and Recovery Research!

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Recent Accomplishments

  • DTRR continues to actively maintain MOBC research portfolio
  • Collaboration with NIH Science of Behavior Change Common Fund
  • Funded N = 17 out of 32 (50%) PAR FOA – R01, R21, and R03
  • Now expired
  • Continue to co-sponsor MOBC satellite meeting – funded by U13

conference grant

  • Reviewing ways to continue U13 funding
  • Published special MOBC sub-section in Journal of Studies on

Alcohol and Drugs

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Shifting Directions for MOBC Portfolio

  • I. Understanding Processes of Recovery (NEW)
  • II. Intersection of Moderation-Mediation and Personalized Medicine
  • III. Advancing Research Methods
  • IV. Defining, Training and Disseminating MOBC Best Practices (NEW)
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New MOBC Direction: Understanding Processes of Recovery

  • Evaluate the nature and timing of relapse episodes using advanced data

collection methods (e.g., Ecological Momentary Assessment) and data analytic techniques (e.g., Dynamic Systems Modeling)

  • Conduct studies that seek to identify and evaluate specific mechanisms that underlie

how mutual help groups and/or continuing care/extended AUD treatments aid in recovery

  • Support basic neurobiological and behavioral research to identify the factors

that facilitate or prevent relapse episodes, and promote resilience

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  • Identify alcohol-related phenotypes and understand how they respond

differently to AUD treatments. Evaluate moderated-mediated pathways among these phenotypes

  • Use dynamic and person-centered statistical modeling approaches to

evaluate heterogeneity among MOBC that impact alcohol use behavior within specific AUD treatments and/or targets of relapse risk

  • Enhance translational research methods by identifying potential

neurobiological, cognitive or genetic processes that may act as potential mechanisms of therapeutic change and AUD behavioral treatment outcome

Shifting MOBC Directions: Intersection of Moderated-Mediation and Personalized Medicine

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Shifting MOBC Directions: Advancing Research Methods

  • Incorporate the use of advanced statistical procedures or new methods

such as computational or mathematical modeling (e.g., dynamic systems modeling) to understand how fluctuations in specific mechanisms of change interact among individuals, their social environments and treatment outcomes

  • Understand how to leverage greater use of technology (e.g., computers) to enhance
  • utreach of empirically-supported alcohol behavioral treatments among harder to

reach populations

  • To monitor daily or in real time MOBC that lead to relapse or sustained behavior

change and determine how they vary among AUD individuals. This includes using state

  • f the art methodologies, such as the Ecological Momentary Assessment to identify

changes in behavior and/or physiological parameters

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New MOBC Direction: Dissemination and Training on MOBC Best Practices

  • Move towards developing MOBC (e.g., best practices) theoretical models

based on empirical evidence and consensus in the field – test the models

  • Further enhance a current empirically-supported behavioral treatment or

develop a novel behavioral treatment based on current MOBC empirical evidence

  • Focus on enhancing training of clinicians and addiction specialists on

adopting MOBC best practices – enhance diversity training efforts

  • Enhance diversity efforts by evaluating how established MOBC within an

empirically-supported AUD treatment operate within understudied and vulnerable populations

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Funding Opportunities….

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Alcohol Use Disorders: Treatment, Services, and Recovery Research

Research Domain #2: Behavioral Therapies and Mechanisms of Behavior Change

  • R01: PA-18-194 (https://grants.nih.gov/grants/guide/pa-files/PA-18-194.html)
  • R21: PA-18-202 (https://grants.nih.gov/grants/guide/pa-files/PA-18-202.html)
  • R03: PA-18-201 (https://grants.nih.gov/grants/guide/pa-files/PA-18-201.html)

Announcement will expire in September, if so, use the following Parent Announcement:

  • R01: PA-18-484 (https://grants.nih.gov/grants/guide/pa-files/PA-18-484.html)
  • R01: PA-18-345 (https://grants.nih.gov/grants/guide/pa-files/PA-18-345.html)
  • R21: PA-18-489 (https://grants.nih.gov/grants/guide/pa-files/PA-18-489.html)
  • R21: PA-18-344 (https://grants.nih.gov/grants/guide/pa-files/PA-18-344.html)

Program Announcements

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Other Program Announcements Understanding Processes of Recovery in the Treatment

  • f Alcohol Use Disorders (Clinical Trial Optional)
  • R01: PA-18-285 (https://grants.nih.gov/grants/guide/pa-files/PA-17-285.html)
  • R21: PA-18-284 (https://grants.nih.gov/grants/guide/pa-files/PA-17-284.html)

Goal of FOA: The purpose of this FOA is encourage applications that seek to examine processes of recovery and relapse in the treatment of Alcohol Use Disorder

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Other Program Announcements

Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R01 Clinical Trial Optional)

  • R01: PA-18-722 (https://grants.nih.gov/grants/guide/pa-files/PA-18-722.html)
  • R21: PA-18-723 (https://grants.nih.gov/grants/guide/pa-files/PA-18-723.html)
  • MOBC language in PA: “NIAAA is also interested in alcohol treatment

research focused on understanding the mechanisms that underlie adherence to engaging in and maintenance of behavior change within

  • ur empirically-supported alcohol behavioral treatments that target

heavy and problematic alcohol use”

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NOT-AA-18-009: Notice of Data-Sharing Policy for Human Subjects Grants Research Funded by the National Institute on Alcohol Abuse and Alcoholism

The purpose of this notice is to inform prospective applicants responding to the current NIAAA-Funding Opportunity Announcements (FOAs) of a new policy whereby the National Institute on Alcohol Abuse and Alcoholism (NIAAA) will expect investigators and their institutions to provide basic plans for submitting grant-related human subjects data to a NIAAA-sponsored data repository, as outlined in this Notice. These plans should be included in the Data Sharing Plan located in the Resource Sharing Plan section of grant applications. This applies to all grant applications (new and resubmitted) that include human subject research, except Fellowship (F), Training (T), Small Business (SBIR/STTR), and Education (R25) grants. For additional information, please contact Dr. Daniel Falk (falkde@mail.nih.gov).

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Additional Housekeeping Items

  • Please send a concept paper (outlining specific aims, hypotheses and

provide description of integrating theory) via email for feedback

  • Remember, we have new clinical trial guidelines that have been

implemented – grants are required to have a clinical trial dissemination plan

  • NIAAA Data Repository – session guidance on Tuesday with Dr. Trish Powell
  • NIAAA is moving to a new office building (July 6th) -

expect some slight delay in communication

  • All yearly grant progress reports are due on time – grants management needs

your help on this

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Recap

  • NIAAA remains committed to MOBC research
  • Encouraging new directions for MOBC research in recovery,

personalized medicine and dissemination

  • Take advantage of our FOAs – keep those

applications coming!

  • Focus on INNOVATION, IMPACT and STRONGER

THEORETICAL MODEL DEVELOPMENT

  • Funding support available from NIAAA
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Helpful Links and References

https://www.nih.gov/about-nih/what-we-do/nih-turning-discovery-intohealth/personalized-medicine (Information on NIH Personalized Medicine Initiative) https://directorsblog.nih.gov/tag/personalized-medicine/ (Dr. Collin’s blog on Personalized Medicine) https://allofus.nih.gov/news-events-and-media/news/personalized-medicine-time-one-person-trials https://www.niaaa.nih.gov/dtrr (NIAAA DTRR Program Director and staff page) https://grants.nih.gov/policy/clinical-trials/reporting/index.htm (New NIH clinical trial guidelines)

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Thank You

For more information, please contact:

Brett Hagman, Ph.D. NIAAA brett.hagman@nih.gov 301-443-0638