!"#$%&'(")*+,'*-.&'+/-0'*%("'#+;:+/98#0'(")*+ !"#$%&'(")*+,'*-.&'+/-0'*%("'#+0%+123(%&'+ !("?'7+K'(2#+ + 4'2-).$+5'6"$%)+1)78$.%) + • L$1)0%#<J#+,MNOP1,!MQ+#:#0'2+-80%2-.$-99:+7"#$%&'(#+ • 5'-()")*+289.39'+#'2-).$+$-0'*%("'#+#"2890-)'%8#9:+"23(%&'#+ ;%%0#0(-33")*+;'$-8#'+0<'+$-0'*%("'#+$%)#0(-")+'-$<+%0<'(=+ )'*-.&'+$-0'*%("'#+;:+$98#0'(")*+0'(2#+0<-0+<-&'+ #'2-).$-99:+7("?'7=++ • ,'&'(0<'9'##>+;%%0#0(-33'(#+%?')+;'*")+0%+-$@8"('+")#0-)$'#+%A+ )'B>+8)7'#"('7+$-0'*%("'#=++ • CLMG+7'0'$0'7+0'(2#+0<-0+<-&'+7("?'7+A(%2+0<'+%("*")-9 + #'2-).$+$-0'*%(:>+;80+0<':+B'('+#"239:+7"#$-(7'7=++ • C<')+0<"#+;'<-&"%(+"#+%;#'(&'7>+-77".%)-9+D)'*-.&'E+#'2-).$+ $-0'*%("'#+$-)+;'+2-)8-99:+7'F)'7+0%+7(-B+-B-:+0<'+8)7'#"('7+ • ,MNOP1,!MQ+$-$<'#+0<'+7("?'7+0'(2#+-)7+0<')+*(%83#+ B%(7#+-)7+$%)0'60#=++ #"2"9-(+7("?'7+0'(2#+&"-+$98#0'(")*=++ • G80+H+2-)8-99:+7'F)")*+)'*-.&'+$-0'*%("'#+"#+-+A%(2+%A+<82-)+ #83'(&"#"%)=+I)7+"0+0:3"$-99:+('@8"('#+('F)'2')0+;:+"0'(-.&'9:+ • K<'+*%-9+"#+0%+-80%2-.$-99:+"7').A:+*(%83#+%A+7("?'7+ %;#'(&")*+0<'+#:#0'2J#+;'<-&"%(=++ 0'(2#+0<-0+('3('#')0+ !"#$%&'$ +-)7+ !"()$*+, +$-0'*%("'#=+ + ,MNOP1,!MQ+P9%B$<-(0 + /98#0'(")*+!("?'7+K'(2# + • R"'(-($<"$-9+-**9%2'(-.&'+$98#0'(")*+"#+8#'7+0%+*(%83+ #"2"9-(+0'(2#=++ – ")".-99:>+'-$<+0'(2+"#+-##"*)'7+0%+-)+")7"&"78-9+$98#0'(=+ – +0<'+$98#0'(#+-('+"0'(-.&'9:+2'(*'7+;-#'7+%)+-+#"2"9-("0:+2'0("$>+ 8).9+S8#0+%)'+$98#0'(+T$%)0-")")*+'&'(:0<")*U+('2-")#=+ • K<'+#"2"9-("0:+%A+V+$98#0'(#+"#+0<'+-&'(-*'+7"#0(";8.%)-9+ #"2"9-("0:+;'0B'')+-99+3-"(#+%A+0'(2#+-$(%##+0<'+$98#0'(#=+ – 0<':+8#'7+0<'+#"2"9-("0:+2'0("$+A%(+7'0'$.)*+#'2-).$+7("?W+ $%)0'60+&'$0%(#+B"0<+0O0'#0+B'"*<0#+X+B'"*<0'7+Y-$$-(7+2'0("$+ • /98#0'(")*+3'(A%(2'7+B<')+7("?+$-$<'+<-#+VZ[+0'(2#=+ ! ! ! !
R-(&'#.)*+_-`'()#+A%(+0<'+,'*-.&'+ 17').A:")*+,'*-.&'+/98#0'(# + /-0'*%("'# + • KB%+#0(-0'*"'#+B'('+0("'7+0%+"7').A:+8#'A89+)'*-.&'+$-0'*%(:+ • C<')+-+)'*-.&'+$98#0'(+"#+"7').F'7>+0<'+0'(2#+")+0<'+ $98#0'(#=++ $98#0'(+;'$%2'+0<'+ %$$/.0"1/%. A%(+0<'+)'B+$-0'*%(:=+ • N')'(-9+%;#'(&-.%)+O+")+-**9%2'(-.&'+$98#0'(")*>+0<'+2%#0+ • _-`'()#+28#0+0<')+;'+'60(-$0'7+A%(+0<'+$-0'*%(:=+ #"2"9-(+0'(2#+-('+2'(*'7+F(#0=++ – I99+3-`'()#+0<-0+$%O%$$8(+B"0<+-+)'*-.&'+#''7+-('+'60(-$0'7+ • !"#$%&%'()&*+,-$./0' "7').A:+0<'+ - +2%#0+#"2"9-(+0'(2#+;:+'6".)*+ -)7+(-)^'7+B"0<+('#3'$0+0%+0<'+#''7#=++ 0<'+$98#0'(")*+3(%$'##+-#+#%%)+-#+-+$98#0'(+%A+#"\' .-. "#+A%(2'7=+ – K<'+0%3O#$%(")*+ ( +3-`'()#+-('+#-&'7+A%(+0<'+)'*-.&'+$-0'*%(:=+ • 1&+)$,-'()&*+,-$./0' ]= +"7').A:+0<'+7("?'7+0'(2+ ! . 0<-0+"#+9'-#0+#"2"9-(+0%+0<'+F(#0+ + + • 1A+-+3-`'()+3('&"%8#9:+8#'7+A%(+-)%0<'(+$-0'*%(:+$%O 0'(2#+")+0<'+9'6"$%)+T0<"#+<-#+-9('-7:+;'')+3('O$%2380'7+A%(+ %$$8(#+B"0<+-+)'*-.&'+#''7>+0<'+3-`'()+"#+7"#$-(7'7=+ 7("?+7'0'$.%)U=+ V= '6"0+0<'+$98#0'(")*+3(%$'##+B<')+-+$98#0'(+%A+#"\'+^+"#+A%(2'7+ 0<-0+$%)0-")#+0'(2+ ! = . ! ! L-)8-99:+!'F)'7+,'*-.&'+ 5%$-9+&#=+N9%;-9+!"#$%&'(: + /-0'*%("'# + • !"a'(')0+#0(-0'*"'#+B'('+-9#%+0("'7+A%(+9'-()")*+)'*-.&'+ $-0'*%("'#+ )23"))4 +T;-#'7+%)+")7"&"78-9+$-0'*%("'#U+-)7+ /)25"))4 + Author identified categories by observing the behavior of WMEB ! T;-#'7+%)+0<'+').('+9'6"$%)U=++ ! New Category Drifted from ! • 623")'7$*328,-40' '-$<+$-0'*%(:+<-#+"0#+%B)+ 2"!32 +7("?+$-$<'>+B<"$<+ AMINO ACID ! MUTATION ! ANIMAL/BODY ! CELL/DIS/SIGN ! "#+$98#0'('7+")7'3')7')09:+A(%2+0<'+%0<'(#=+ ORGANISM ! DIS ! • 9)25")'7$*328,-4 W+-99+7("?'7+0'(2#+-('+3%%9'7+")+-+#")*9'>+ ,2"432 + $-$<'=+K<"#+2-:+;'+;')'F$"-9+"A+289.39'+$-0'*%("'#+7("?+")0%+0<'+ #-2'+8)7'#"('7+#'2-).$+$9-##'#=++ • !$#+&-,'7$*328,-40' 4"5# +9%$-9+-)7+*9%;-9+7("?+$-$<'#+-('+ 2-")0-")'7+T"='=>+-+7("?'7+0'(2+*%'#+")0%+;%0<+$-$<'#U=+/98#0'(")*+ "#+3'(A%(2'7+%)+;%0<+$-$<'# =++ Independent domain expert identified categories ! ! !
/%23-(-.&'+Q'#890#+B"0<+!"a'(')0+ 1)b8')$'+%A+L-)8-99:+!'F)'7+ !("?+/-$<'+40(-0'*"'#+ ,'*-.&'+/-0'*%("'# + P"(#0>+0<':+2'-#8('7+0<'+"23-$0+%A+0<'+2-)8-99:+7'F)'7+ )'*-.&'+$-0'*%("'#+-#+-&'(-*'+3('$"#"%)+%&'(+0<'+]Z+0-(*'0+ $-0'*%("'#W++ 6//&+,.+$,3*'$.!35$,"1&$%.!2$3127.&()1"'$%.)$18"1(3+!$9. ! ! ! ! Q'#0-(.)*+B"0<+0<'+!"#$%&'('7+,'*-.&'+ /%2;")")*+L-)8-99:+!'F)'7+-)7+ /-0'*%("'# + I80%2-.$-99:+!"#$%&'('7+,'*-.&'+/-0'*%("'# + _('&"%8#9:>+0<'+;%%0#0(-33'(+$%897+%)9:+;')'F0+A(%2+0<'+7"#$%&'('7+ c8'#.%)W+/-)+,MNOP1,!MQ+9'-()+8#'A89+)'*-.&'+$-0'*%("'#+;':%)7+ $-0'*%("'#+-?'(+0<':+B'('+9'-()'7+T"='=>+-?'(+2-):+"0'(-.%)#U=+ B<-0+-+<82-)+'63'(0+7'F)'#d+ + + K<'#'+'63'("2')0#+('#0-(0+0<'+;%%0#0(-33")*+3(%$'##>+3(%&"7")*+"0+ K<'+#:#0'2+B-#+")".-9"\'7+B"0<+0<'+]Z+0-(*'0+$-0'*%("'#+I,!+0<'+ 2-)8-99:+7'F)'7+)'*-.&'+$-0'*%("'#W+ B"0<+0<'+-80%2-.$-99:+7"#$%&'('7+)'*-.&'+$-0'*%("'#+")".-99:=++ ! ! ! !
4'2"OI80%2-.$+M).0:+4'0+Q'F)'2')0+ I)-9:#"#+%A+Q'#890#+A%(+1)7"&"78-9+4'2-).$+ ef:-#+-)7+_-)0'9>+,II/5+VZZgh + /-0'*%("'# + • 4%2'+#'-($<+')*")'+$%23-)"'#+2-")0-")+9"#0#+%A+)-2'7+ ')..'#+0%+"23(%&'+#'-($<+('#890#=++ • L-)8-99:+$%)#0(8$.)*+-)7+2-")0-")")*+)-2'7+').0:+ 9"#0#+"#+'63')#"&'>+#%+0<':+-('+")0'('#0'7+")+-80%2-0'7+ *,+',#:".*$2. +0'$<)"@8'#=++ • 4'2"O#83'(&"#'7+0'$<)"@8'#+-('+8#'A89+A%(+0-(*'.)*+ #3'$"F$+7'#"('7+$-0'*%("'#>+B"0<+2")"2-9+<82-)+")380=+ • G80+2-)8-9+('F)'2')0#+-)7+'((%(+$%(('$.%)+-('+%?')+ )''7'7+#")$'+0<'#'+0'$<)"@8'#+-('+)%0+3'(A'$0+-)7+$-)+ #8a'(+A(%2+#'2-).$+7("?=++ ! ! ! ! i':+j;#'(&-.%)# + 4'2"O483'(&"#'7+Q'F)'2')0 + • I2;"*8%8#+#''7+B%(7#+%?')+9'-7+0%+#'2-).$+7("?=++ ;<," W+")$%(3%(-0'+ 1$2$'3+!$.8$$/43!-. 0<-0+-#^#+-+<82-)+ 0%+"7').A:+T-0+2%#0U+%)'+'((%(+")+'-$<+"0'(-.%)=+ Q%2-)+N%7+4''7#W+ :&+$1'3;.<$)5=+$;.>3!!=%;.?=+";.6)"22".. ]= ('2%&'+"0'2#+0<-0+-('+7"#0(";8.%)-99:+#"2"9-(+0%+0<'+ M63-)7'7+5"#0W+ :31%;.@$+=%;.:""+;.:$1!=17;.3%5$1"&/;.?=)&5$1;. 2-)8-99:+"7').F'7+'((%(#=+ A315#;.!"($5;.B"++$;.B=+;.C. V= 7:)-2"$-99:+$<-)*'+0<'+A'-08('+#3-$'+;-#'7+%)+0<'+ • I2;"*8%8#+')..'#+0<-0+#<-('+%)'+#')#'+8#8-99:+7%+)%0+ '((%(+ #<-('+%0<'(+#')#'#+0<-0+-('+#'2-).$-99:+#"2"9-(=+ m= ('$%2380'+0<'+#"2"9-("0:+%A+'-$<+').0:+B"0<+('#3'$0+ – P%(+'6-239'W+ 6))2$ +-)7+ B=+ +;%0<+#<-('+0<'+#')#'+ /jL_I,k =++ 0%+0<'+#''7#>+-)7+7"#$-(7+0<%#'+B"0<+9%B+#"2"9-("0:+ – G80+0<'"(+%0<'(+#')#'#+T PQl1K+ -)7+ /M5M4K1I5+Gj!k U+-('+ #'2-).$-99:+7"a'(')0=+++ ! ! ! !
Recommend
More recommend
