Micro-Bubbles By: Givi Basishvili Xavier Marrero What are - - PowerPoint PPT Presentation

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Mar 05, 2023 540 likes •746 views

Micro-Bubbles By: Givi Basishvili Xavier Marrero What are Micro-Bubbles? Small bubbles (>10m; 0.000001meters) Can hold: Oxygen - Genetic Info (DNA) - Drugs - Used for Medical Purposes 10m Purpose Deliver Chemicals

SLIDE 1

Micro-Bubbles

By: Givi Basishvili Xavier Marrero

SLIDE 2

What are Micro-Bubbles?



Small bubbles (>10µm; 0.000001meters)



Can hold:

Oxygen
Genetic Info (DNA)
Drugs



Used for Medical Purposes

10µm

SLIDE 3

Purpose

 Deliver Chemicals to

specific areas.

 Targeted and popped

by Ultrasound.

 Can be used to treat

cancer, lung failure and

ther disorders.

SLIDE 4

Oxygen Bubbles

 Will keep patients with

lung failure alive!

 Injected directly into

blood.

 Oxygen acquired by

Red blood cells and Hemoglobin.

SLIDE 5

Bubble Chemistry

 Components:

Lipid
Oxygen
Water

 Intermolecular

Forces

SLIDE 6

Engineering Bubbles

Lipid + Oxygen + Sound Waves = Oxygen Bubbles

SLIDE 7

Research

 Create stable Bubbles  Determine best storing conditions.  Determine bubble properties.  Test in vivo (living organisms)

Bubble

SLIDE 8

STABILITY TESTS

 Problem: Our micro-bubbles only last for 3-5

days so we want to make it as stable as possible.

 Perform different experiments to test whether

leaving the micro-bubbles in refrigeration is more stable than leaving it outside in room temperature.

 First test: Leave the micro-bubbles outside in room

temperature.

 Second test: Leave the micro-bubbles in a

refrigerator.

SLIDE 9

STABILITY TEST’S RESULTS

10 20 30 40 50 60 20 40 60 80 100 120 Gas % Time (hrs) Gas % Over Time of Refrigeration vs. Room Temperature

Non Refrigerated Refrigerated



The gas density decreased in both experiments but greatly in the room temperature micro-bubbles.

SLIDE 10

CONCLUSION FOR STABILTY TESTS

 The micro-bubbles left in the refrigerator

were far more stable that the ones left

utside in room temperature.

SLIDE 11

Storage: Rotation

Bubbles growing over time.

 Hypothesis: Rotation will prevent bubble coalescence.

SLIDE 12

Data

SLIDE 13

Size Growth

SLIDE 14

Conclusion #2

 Rotation = Higher Kinetic Energy = More

Instability

 Collision with the wall also causes damage.

SLIDE 15

Future Tests

 Testing different lipid formulas.  Vary engineering used to create bubbles.  Determine the elasticity of bubbles.

SLIDE 16

References



Sirsi, S. R., M. A. Borden. Microbubble compositions, properties and biomedical applications. Department of Chemical Engineering, Columbia University, New York. April 16, 2009.



Ferrara, Katherine, Rachel Pollard, Mark Borden. Ultrsound Microbubble Contrast Agents: Fundamentals and Application to Gene and Drug Delivery. The Annual Review of Biomedical

Engineering. 2007



http://www.research.philips.com/newscenter/archive/2008/backgrounders/080930- microbubbles.html



http://www.safework.sa.gov.au/contentPages/images/ChemicalsPic.gif



http://api.ning.com/files/FSiO4LhKSO6y92- wFwrcoGwiDXkpvVevmv9mNi3UQ6Ngb8HukzRAXJ4qyTSYRGH9KRAKj-aC4y449g3Y- SBSaAqCZxjvJJKy/engineering.jpg



http://www.bradfitzpatrick.com/store/images/products/thumbs/bo002-cartoon-desk-clipart.jpg



http://images.clipartof.com/thumbnails/5081-Female-Scientist-Holding-Pencil--Clipboard- Clipart.jpg



http://kidneyinthenews.files.wordpress.com/2008/03/19443.jpg

SLIDE 17

Acknowledgements

 Prof. Mark Borden  Ed Swanson  Nathan Lee  Chemical Engineering Department at

Columbia University

 Dr. Sat Bhattacharya  Harlem Children Society

SLIDE 18

Thank You for Listening.

Any questions?