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MECIR Toby Lasserson April 2016 Trusted evidence. Informed - - PowerPoint PPT Presentation
MECIR Toby Lasserson April 2016 Trusted evidence. Informed - - PowerPoint PPT Presentation
MECIR Toby Lasserson April 2016 Trusted evidence. Informed decisions. Better health. Session overview MECIR: brief history CEU review screening & use of MECIR MECIR 2.0 MECIR standards Developed from existing Handbook guidance MECIR
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MECIR standards
Developed from existing Handbook guidance
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MECIR standards
Developed from existing Handbook guidance Extensive consultation process
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MECIR standards
Developed from existing Handbook guidance Extensive consultation process Never apply all at once
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MECIR standards
Developed from existing Handbook guidance Extensive consultation process Never apply all at once Supported: Sofuware prompts for users
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Screening
Spot the missing piece
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Key learning points
Implement Implementation o ation of f pr prot
- toc
- col me
- l methods
thods Int Interpr erpretation ation Inc Inconsist
- nsistenc
ency y Excluding studies due to
- utcome reporting
Unacknowledged departures from protocol Subgroups (misuse & interpretation) Analysis errors SoF tables footnotes/ downgrading decisions Use of GRADE Prescriptive conclusions Results in text/tables Mismatch between full- text & summary versions
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Feedback loop for MECIR
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Feedback loop for MECIR
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MECIR 2.0
Of sets & standards…
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New developments
4 sets (conduct; reporting protocol; reporting review & updating) Booklet format Standards revised to reflect what screening has taught us
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Changes to conduct standards
5 fewer conduct standards (75 versus 80) Surviving standards draw on learning points from screening & related audit work
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New set for reporting protocol
44 standards to mirror Conduct Standards Investing effort in formulating question
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Changes to reporting standards
Reporting standards revised to incorporate learning points from review screening Clarification based on user feedback
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Updating
Challenge notion that updating = adding studies Start with a re-evaluation of the original research question (new protocol if necessary) Separation of standards between planning & considerations for reporting
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Where next?
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Supporting implementation
Finalise & circulate the final sets as booklet Handbook & sofuware integration Update learning resources Produce targeted guidance on aspects of conduct & reporting that pose greatest challenge
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