Malaysian Healthy Ageing Society Research Center for Anti-Aging - PowerPoint PPT Presentation

Organised by: Co-Sponsored: Malaysian Healthy Ageing Society

Research Center for Anti-Aging Technology Development Muscle Health Promotion System for Prevention of Muscle Function Decrease Cheolmin Kim, M.D., PhD

Agenda  Introduction  About RCAATD  Device Development  Functional Food Development

Aging ? Anti-Aging? Aging ? multidimensional process of physical, psychological, and social changes in a person over time Anti-Aging ? slowing down or reversing the processes of aging to extend both the maximum and average lifespan The target of Anti-Aging ? • slowing down the aging processes • keep healthy living during aging • So well aging Exercise, Nutrition, Relation, Participation 4/49

Different views give different image. However, The real characteristic is same. It’s a cup for drinking coffee conveniently, safely, and comfortably. • Anti-Aging in Technology (view of engineer) • Healthy Aging in Practice (view of clinician) • Active Aging in Society (view of sociologist) • Well Aging for better life (view of people) Even though there’s controversy still now. (cf. Anti -aging Medicine) 5

Walking is the best and simplest way of exercise Exercise Walking is best Activation of almost every body function cognition ↑ Dementia↓ BP control Back pain↓ Good posture Heart attack ↓ Osteoporosis↓ DM ↓ Weight load Energy control Energy control GH & hormone GI function Anti- aging↓ balance control cognition ↓ Dementia ↑ Every function↓ No movement 6/49

Skeletal muscle wasting in cachexia and sarcopenia Diseases Cannot Work. Cannot Move. Diseases Cannot Exercise In vicious circle

If he/she cannot Walk by himself/herself ? EXERCISE MIMETICS Functional Nutrition ↑ Foods Synergistic → Metabolism ↑ Effect Circulation ↑ Devices Assisted exercise → M. function ↑ Self exercise → Recovery 8/49

Walking is the best and simplest way of exercise Age-related increase of inflammation in fat t. Age-related Decrease of Muscle Function Sarcopenia Energy ↑ M. cell ↑ Circulation ↑ Infl. ↓ Lipolysis ↑ Metabolism ↑ Functional Devices Foods Whole body Local Effects Effects

Organization of R&D team in RCAATD Functional Foods Donga Univ. Natural Hub Dongeu Univ. Sea-origin Evaluation model Pusan Univ. Device develop Clinical test System develop BTP SPIC Standardisation Devices

Integration of effective stimulation modules Devices Vibration Light Heat Magnetic Electric

BIA (Bio-electrical Impedance Analysis) module 1980 1900 1960 1850 1940 1920 Series1 1800 1900 Series1 Series2 1750 Series2 1880 Series3 Series3 1860 1700 1840 1650 1820 1 2 3 4 5 1600 1 2 3 4 5

Processes and Aim of Functional Foods Development Functional Foods • Resources Library • Objective evaluation and Clinical test • Get permission of Functional Food from Korean FDA • Global marketing

Resources Library of Functional Foods Functional Food Resources from Marin Origin

Objective evaluation of Function of Food materials In vitro Cell Culture Model using C2C12 myoblasts  C2C12 cells were originally obtained by Yaffe and Saxel (1977) through selective serial passage of myoblasts cultured from the thigh muscle of C3H mice 70 h after a crush injury.  These cells were shown to be capable of differentiation.  C2C12 cells are a useful model to study the differentiation of non-muscle cells to skeletal muscle cells (e.g., myosin phosphorylation mechanisms) and express muscle proteins and the androhen receptor (AR).  C2C12 cells can be used to study the differentiation of myoblast and osteoblast.