Laurie Haws, PhD, DABT ToxStrategies, Inc Comments to the USEPA - PowerPoint PPT Presentation

Laurie Haws, PhD, DABT ToxStrategies, Inc Comments to the USEPA Science Advisory Board Dioxin Review Panel October 27, 2010 Comments Prepared On Behalf of US Magnesium

NHANES 95 th Percentile 100 NHANES 75 th Percentile NHANES 50 th Percentile NHANES 25 th Percentile TEQ Serum Concentration (pg/g lipid) NHANES 5 th Percentile 10 NHANES Max NHANES Min EPA OSF RL 1E-4 NHANES ¡TEQ ¡DL ¡ EPA OSF RL 1E-5 1 EPA OSF RL 1E-6 Cancer-based RfD JECFA TDI 0.1 0.01 12-19 20-29 30-44 45-59 60+ NHANES Age Group

100.0 Terminal TEQ Serum Concentration (pg/g lipid) 34.5 14.6 Background (14.0) 10.0 1.0 JECFA TDI EPA RfD Non-cancer Toxicological Benchmarks

283.5 Terminal TEQ Serum Concentration (pg/g lipid) 100.0 34.5 Background (14.0) 10.0 2.9 1.0 0.3 0.1 0.0 0.0 EPA OSF RL 1E-4 EPA OSF RL 1E-5 EPA OSF RL 1E-6 Cancer-based RfD JECFA TDI Cancer-based Toxicological Benchmarks

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Cancer-based RFD Lifetime Average TEQ Serum Concentration (pg/g lipid) 100.00 JEFCA TDI Background 10.00 EPA OSF RL 1E-4 1.00 EPA OSF RL 1E-5 0.10 EPA OSF RL 1E-6 0.01 3.7 9.4 90 200 300 500 1000 2000 Soil Concentration (ppt)