Laurie Haws, PhD, DABT ToxStrategies, Inc Comments to the USEPA - - PowerPoint PPT Presentation

Laurie Haws, PhD, DABT ToxStrategies, Inc Comments to the USEPA Science Advisory Board Dioxin Review Panel October 27, 2010

Comments Prepared On Behalf of US Magnesium

0.01 0.1 1 10 100 12-19 20-29 30-44 45-59 60+ TEQ Serum Concentration (pg/g lipid) NHANES Age Group NHANES Max NHANES Min EPA OSF RL 1E-4 EPA OSF RL 1E-5 EPA OSF RL 1E-6 Cancer-based RfD JECFA TDI

NHANES ¡TEQ ¡DL ¡

NHANES 95th Percentile NHANES 75th Percentile NHANES 50th Percentile NHANES 25th Percentile NHANES 5th Percentile

34.5 14.6 1.0 10.0 100.0 JECFA TDI EPA RfD Terminal TEQ Serum Concentration (pg/g lipid) Non-cancer Toxicological Benchmarks

Background (14.0)

2.9 0.3 0.0 283.5 34.5 0.0 0.1 1.0 10.0 100.0 EPA OSF RL 1E-4 EPA OSF RL 1E-5 EPA OSF RL 1E-6 Cancer-based RfD JECFA TDI Terminal TEQ Serum Concentration (pg/g lipid) Cancer-based Toxicological Benchmarks

Background (14.0)

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!"#$%&'()$*+,-&,.'/.0+,$12343$502067$ 83&$19':7$

+,-./012345678859120-:;< +,-./012345=5>"&5??@5;1A8 +,-./012345=5)$5??@5;1A8 +,-./012345=5'##5??@5;1A8 +,-./012345=5!###5??@5;1A8 +,-./012345=5$###5??@5;1A8 BC75DEF GBHI75JFK +,-./012345678859120-:;< +,-./012345=5>"&5??@5;1A8 +,-./012345=5)$5??@5;1A8 +,-./012345=5'##5??@5;1A8 +,-./012345=5!###5??@5;1A8 +,-./012345=5>"&5??@5;1A8 +,-./012345=5)$5??@5;1A8 +,-./012345=5'##5??@5;1A8 +,-./012345=5!###5??@5;1A8 +,-./012345=5$###5??@5;1A8 +,-./012345=5$###5??@5;1A8 BC75DEF +,-./012345678859120-:;< +,-./012345=5>"&5??@5;1A8 +,-./012345=5)$5??@5;1A8 GBHI75JFK BC75DEF

Lines appear generally in same order on graph

0.01 0.10 1.00 10.00 100.00 3.7 9.4 90 200 300 500 1000 2000 Lifetime Average TEQ Serum Concentration (pg/g lipid) Soil Concentration (ppt)

Background JEFCA TDI EPA OSF RL 1E-4 Cancer-based RFD EPA OSF RL 1E-6 EPA OSF RL 1E-5