LANABLUE NATURAL RETINOID-LIKE ACTIVE FOR WRINKLE REDUCTION - - PowerPoint PPT Presentation
ANTI-AGING/ ANTI-WRINKLING/ CELL TURNOVER LANABLUE NATURAL RETINOID-LIKE ACTIVE FOR WRINKLE REDUCTION Agenda - Lanablue Introduction on Lanablue Efficacy studies Effect of Lanablue on gene expression PCR
ANTI-AGING/ ANTI-WRINKLING/ CELL TURNOVER
– Effect of Lanablue™ on gene expression – PCR Results for Cell Proliferation/Differentiation Markers – Effect of Lanablue™ on differentiation markers on human skin explants – Clinical evaluation of the smoothing effect – Consumer evaluation
Origin: Blue-green algea extract rich in vitamis, amino acids and proteins. Cosmetic properties: Retinoid-like activity without any side effects. Skin benefits: Reduces the appearance of wrinkle and smooths the skin
Klamath Lake is a basin covering 615 km2, with an average depth ranging from 110 to 120
percolating from Crater Lake, which is a very extraordinary geology. The situation has created water with outstanding mineral wealth. The thick layer of sediments bestow on Klamath Lake its highly unique nutritional properties. The lake is also called Medicine Lake, the Shield of the Volcano or the Sleeping Monster. The Klamath Indians say that the water of the Lake has the power to confer shamanistic powers
A unique micro-algae extract, from Cyanophyta class. This bacterium fixes the atmospheric nitrogen and helps maintain the unique protected eco-system of Klamath Lake. The role of this blue-green alga has been vital in the evolution of species. This alga appeared around 3.5 billion years ago and is the first photosynthetic oxygen-producing organism. It is a creator of atmospheric oxygen, which is essential for all species. Aphanizomenon flos-aquae var.flos aquae (invisible living water flower)
Harvesting process: 1: Transportation through conveyors 2: The alga is filtered by centrifuging 3: Refreshing around 5°C 4: Drying through a patented convection- evaporation process called “refractance window™”
LANABLUE
Harvested during algae bloom between end of August and end of October exclusively on the lake. Characteristics of the blue-green alga after treatment
Blue color powerful active ingredient
Aphanizomenon flos-aquae var.flos aquae is rich in:
Isoleucine, Leucine, Phenylalamine & Tyrosine, Lysine.
Vitamin B1 (Thiamine A): favour micro-circulation & capillary permeability Vitamin B2 (Riboflavin): tissue oxygenation Vitamin B5 (Pantothenic Acid:):reinforce hair Vitamin B6 (Pyridoxine): dandruff prevention Vitamin B12 (Cobalamione): dandruff elimination Vitamin C: Antioxidant Lysine: Amino acids essential to collagen synthesis Methionine: Its sulphide content allows numerous tissue proteins synthesis Proline: A collagen constituent, increase its synthesis Serine: Essential for cells wall phospholipids synthesis
The wealth and diversity of its chemical composition has allowed it to be used as a food complement for physical well-being. Its composition of polyunsaturated essential fatty acids is of real importance in regulating the metabolism of lipids. Micro-algae improve digestive assimilation by increasing the concentration of certain digestive enzymes. Its consumption increases children's capacity for intellectual concentration. In general, the consumption of micro-algae helps to maintain the state of well being, particularly when the body is unsettled by physiological causes. It reinforces the immune system and exercises a biomodulating action and it possesses anti- inflammatory and anti-oxidant properties.
Because of its composition, Lanablue™ has been studied for anti-aging properties and retinoid- like properties. Skin differentiation is a genetically programmed process base on specific genes:
involved in the repair process.
Retinoid especially acts on these genes to improve skin roughness. superficial wrinkles and pigmentation problems. Its effects will be to:
Decrease gene expression of filaggrin, loricrin, calmodulin Increase gene expression of Cal A & B Decrease gene expression of MMP1, MMP2
Protocol
A 2% Lanablue™ applied twice a day for 2 days on skin explant Gene expression by cDNA microarrays Results
Vimentin MMP11 MMP3 Stromolysine1 IL-2R g IL2RG Cytokine R p64 Filaggrin Loricrin Proteins related to differentiation Psoriasin Ornithine decarboxylase Calmodulin Like skin protein TIMP1 EPA transine1 Integrin beta 4 Elafin, ESI, SKALP Spermidine acethyltransferase
Lanablue™ represents a natural alternative to retinoid without any side effects
Lanablue™ regulates epidermal differentiation for a better skin regeneration
Protocol
Immunological marking on a skin explant. The explants are then treated for 48 hours with a solution containing 3% Lanablue™.
Results
Protocol
The analysis focus on:
wrinkles number and their depth. A decrease shows a smoothing effect.
isotropy, no directions are favored. Wrinkles tend to orientate all furrows. A diminution of the isotropy shows a smoothing effect.
Consumer Questionnaire
These illustrations show the decrease of the wrinkles and the smoothing effect
In 21 days only, the cream containing Lanablue™ has been appreciated by 95% of the women.
Lanablue™ smoothes the skin for a younger and healthier appearance
Recommended dosage:
1 to 5%
Potential Applications:
INCI name: Sorbitol (and) Water (and) Algae Extract
Should be incorporated at the end of the manufacturing process, at a temperature of 35°/40°C
To focus on…
Innovations – Performance – Safety
components.
2015-12-09