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KD Research in London UK Prof Linda Greensmith Department of - PowerPoint PPT Presentation

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QUEEN SQUARE INSTITUTE OF NEUROLOGY KD Research in London UK Prof Linda Greensmith Department of Neuromuscular Diseases Queen Square Institute of Neurology University College London QUEEN SQUARE INSTITUTE OF NEUROLOGY UK KD Team: a coherent

  1. QUEEN SQUARE INSTITUTE OF NEUROLOGY KD Research in London UK Prof Linda Greensmith Department of Neuromuscular Diseases Queen Square Institute of Neurology University College London

  2. QUEEN SQUARE INSTITUTE OF NEUROLOGY UK KD Team: a coherent research program from the lab to the clinic • Queen Square UCL Institute of Neurology: Linda Greensmith, Pietro Fratta, Michael Hanna, Bilal Malik, Charlotte Spicer & Helen Devine • Oxford University: Carlo Rinaldi, Catheryn Wooi Lim, Mitra Forouhan, Ruth Ellerington & Subhashis Banerjee A collegiate & collaborative research group

  3. QUEEN SQUARE INSTITUTE OF NEUROLOGY UK National KD Clinic at Queen Square Institute of Neurology • National Registry established of all KD patients in UK in 2005 • KD Clinic established by Pietro Fratta at Queen Square in 2014 • Clinic joined by Carlo Rinaldi (Oxford) in 2018 • Team includes a specialist research nurse (Luca Zampedri) and a MND nurse consultant (Jan Clarke), a research physiotherapist (Gita Ramdharry) • Dedicated National Clinic enables • KD Patient cohorts • KD natural history studies • KD patient biobank of samples • KD biomarker studies: “wet”; “imaging” eg muscle MRI: QUANTITATIVE “TRIAL READY”

  4. QUEEN SQUARE INSTITUTE OF NEUROLOGY YOU TUBE: https://www.youtube.com/watch?v=_fBGIuGQXVA

  5. QUEEN SQUARE INSTITUTE OF NEUROLOGY Eric Mager - UK

  6. QUEEN SQUARE INSTITUTE OF NEUROLOGY 2012/13 KD-UK Charity established by Kate Hopps: The UK’s first and only charity for KD

  7. QUEEN SQUARE INSTITUTE OF NEUROLOGY First UK KD Patients Day March 2017 >140 patients, carers and healthcare workers - UK, Canada, Denmark and Australia!

  8. QUEEN SQUARE INSTITUTE OF NEUROLOGY European collaborations in KD: European Neuromuscular Centre A worldwide network

  9. QUEEN SQUARE INSTITUTE OF NEUROLOGY 1 st ENMC Workshop in KD: March 2015 TOWARDS A EUROPEAN CONSORTIUM FOR RESEARCH AND PATIENT CLINICAL MANAGEMENT IN KD 15 - 17 February 2019 Second ENMC meeting on KD Organisers: Dr Pennuto (Italy), Dr Soraru (Italy), Prof Greensmith (UK), Dr Pradat (France) Key Outcomes: 1st International Conference in KD 2019/20

  10. QUEEN SQUARE INSTITUTE OF NEUROLOGY Investigating Disease Pathways in Kennedy’s disease Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology University College London

  11. QUEEN SQUARE INSTITUTE OF NEUROLOGY Our lab research in KD is focused on two main areas 1. to fully understand the reasons why motor neurons and muscle degenerate in KD - to pinpoint specific targets for drug development 2. Test treatment strategies in mouse model and human cells

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