Journey of SCAD Research Dr Abi Al-Hussaini Objectives Where we are - - PowerPoint PPT Presentation

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Journey of SCAD Research Dr Abi Al-Hussaini Objectives Where we are - - PowerPoint PPT Presentation

Dec 09, 2022 172 likes •681 views

Journey of SCAD Research Dr Abi Al-Hussaini Objectives Where we are so far Before the research day On the day of research After the research day Preliminary Data How can you help Where we are so far 328 registrants to

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Journey of SCAD Research

Dr Abi Al-Hussaini

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Objectives

  • Where we are so far
  • Before the research day
  • On the day of research
  • After the research day
  • Preliminary Data
  • How can you help
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Where we are so far


  • 328 registrants to the SCAD website
  • 20 from Europe
  • 287 Online Questionnaire completed
  • New website to be launched
  • European Collaboration
  • 50 patients seen in research study
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Before the research day 


Thank you email and Link to the SCAD Questionnaire SCAD MAILBOX Registration to the SCAD UK website With interest in participating in research

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SCAD diagnosis verified

Invitation for research Date

Medical data and Angiogram requested

Screening consent

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Research date

Patient information sheet and consent form Confirmation email Travel arrangement Any questions

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On the day

Arrival Consent Imaging Flow mediated diliation SWS MRI CT Clinical History & Examinati

  • n

Optional Skin Biopsy Retinal Imaging Bloods for Biobankin g Summary

  • f MRI

Clinical Review Questions

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Flow Mediated Dilation

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Flow Mediated Dilation

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Occlusion Cufg release

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Intimal Medial Thickness

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MRI

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CT

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Biobanking

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Skin Biopsy

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Fibroblast cell culture

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Retinal Photography

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Clinical Phenotyping

  • History
  • Examination
  • Height and Arm Span
  • Wight and BP and HR
  • Examination of Joints and connective

tissue

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Following research day

  • Analysis of data
  • Generate Reports
  • Summary letter
  • Follow up Call
  • Clinic Follow up
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Preliminary data

  • Heterogeneous Phenotype
  • Young
  • Peri/ Post partum
  • Perimenapausal
  • Men
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Menstrual cycle

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Hormonal changes

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Hormonal changes in Menopause

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Hormonal changes with Pregnancy

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So far …….

  • Most SCAD in the luteal phase
  • Perimenapause
  • Post partum
  • Suggests a hormonal aetiology
  • In men….. Not so clear
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  • Many patient with cyclical recurrent

symptoms commonly in the luteal phase

  • Improvement of Symptoms with

Mirena

  • Role of Diltiazem to help with

symptoms

  • ? Aetiology may be Spasm
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Imaging

  • CT cohort

Healing of the dissection Seen as early as 4 weeks Aids clinical management

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  • Magnetic Resonance Angiogram

Vascular abnormality Cardiac MRI No significant infarction, no significant damage Particularly in the conservative managed

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Clinical

  • Heterogeneous population
  • Features of hypermobility
  • Most patient have many side efgects from

medications

  • Post traumatic Stress, Depression and

Anxiety

  • Recurrence rate
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Development

  • Educate the Cardiology care service
  • Education of all medical professionals
  • Specialized Rehab program for your

patients

  • Understanding the Psychological

impact and provide support

  • Referrals
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How can you help?

  • Registry
  • Questionnaire
  • Data retrieval
  • Research day
  • Contact us
  • Healthy volunteers
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Thank you

BRU stafg

SCAD participants

AM Marsh Ellie Clark BRU nurses Jay Gracey K Green B Wreck K Cooper M Harrison E Beeston IT Support S Sterland R Bramley N Holden Dr Adlam Dr G Mccan Dr Will Adir Francesca Sinai Bart Wagner