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Intracoronary Compared with Intravenous Bolus Abciximab Application During Primary Percutaneous Coronary Intervention Cardiac Magnetic Resonance Substudy of the AIDA STEMI trial Holger Thiele, MD; Jochen Whrle, MD; Henning Suenkel, BSc;


  1. Intracoronary Compared with Intravenous Bolus Abciximab Application During Primary Percutaneous Coronary Intervention Cardiac Magnetic Resonance Substudy of the AIDA STEMI trial Holger Thiele, MD; Jochen Wöhrle, MD; Henning Suenkel, BSc; Josephine Meissner, MD; Sebastian Kerber, MD; Bernward Lauer, MD; Matthias Pauschinger, MD; Ralf Birkemeyer, MD; Christoph Axthelm, MD; Rainer Zimmermann, MD; Petra Neuhaus, PhD; Oana Brosteanu, PhD; Steffen Desch, MD; Matthias Gutberlet, MD; Gerhard Schuler, MD; Ingo Eitel, MD on behalf of the AIDA STEMI Investigators

  2. Disclosures Off-label use of IC abciximab Funding: Unrestricted grant by Lilly, Germany University of Leipzig – Heart Center University of Leipzig, Clinical Trial Centre Leipzig: supported by the Federal Ministry of Education and Research (BMBF) FKZ 01KN1102 Potential Conflict of Interest: Research Funding: Terumo, Lilly. Maquet Cardiovascular, Teleflex Medical Consulting: Maquet Cardiovascular, Avidal Speaker Honoraria: Lilly, Astra Zeneca, Daiichi Sankyo, Boehringer Ingelheim, Maquet Cardiovascular, Medicines Company

  3. Background GP IIb/IIIa IC versus IV 2 x Bolus within 10 min. 180 μ μ μ μ g/kg eptifibatide IC versus IV, subsequently 2 μ μ μ μ g/kg -1 .min -1 continuous infusion i.v. for 18 h IPA Periphery (20 μ μ mol/L ADP) μ μ GpIIb/IIIa Receptor-Blockade 110 110 P=0.67 100 100 P=0.013 P=0.995 P<0.001 P=0.001 90 90 80 80 % Receptor-Blockade 70 70 %IPA 60 60 50 50 40 40 30 30 20 20 10 10 0 0 15 min Baseline 30 min 60 min Bolus 1 Bolus 2 Bolus 1 Bolus 2 post Bolus post Bolus post Bolus Peripheral blood Blood coronary sinus IC Eptifibatide n=21 IV Eptifibatide n=19 Deibele et al. Circulation 2010;121:784-791

  4. Background Abciximab IC versus IV 30-day Mortality Intracoronary abciximabIntravenous abciximab Odds ratio Odds ratio Study or Subgroup Events Total Events Total Weight M-H, Fixed 95% M-H, Fixed 95% CICERO 2010 5 271 263 33.7% 0.69 7 CRYSTAL AMI 2010 0 25 23 7.4% 0.29 (0.01;7.59) 1 Dominguez-Rodriguez 2009 0 25 Not estimable 25 0 EASY-MI 2010 0 53 52 Not estimable 0 Iversen 2011 2 185 170 44.8% 0.20 (0.04;0.92) 9 Thiele 2008 2 77 14.1% 0.66 (0.11;4.05) 77 3 Total (95%) 636 610 100.0% 0.43 (0.20;0.94) 9 20 Total events Heterogeneity: Chi 2 =1.88, df=3 (P=0.60);I 2 =0% 0.01 0.1 1 10 100 Test for overall effect: Z=2.11 (P=0.03) Favors IV Favors IC 30-day Myocardial Infarction Intracoronary abciximab Intravenous abciximab Odds ratio Odds ratio Study or Subgroup Total Weight M-H, Fixed 95% M-H, Fixed 95% Events Total Events 3 271 4 263 27.5% 0.72 (0.16;3.27) CICERO 2010 0 53 0 52 Not estimable EASY-MI 2010 5 185 8 170 55.5% 0.56 (0.18;1.75) Iversen 2011 0 77 2 77 17.0% 0.19 (0.01;4.13) Thiele 2008 Total (95%) 586 0.54 (0.23;1.28) 562 100.0% 636 Total events 8 14 Heterogeneity: Chi 2 =0.58, df=2 (P=0.75);I 2 =0% 0.01 0.1 1 10 100 Test for overall effect: Z=1.39 (P=0.17) Favors IC Favors IV 30-day Target Vessel Revascularization Intracoronary abciximab Intravenous abciximab Odds ratio Odds ratio Study or Subgroup Total Weight M-H, Fixed 95% M-H, Fixed 95% Events Total Events 9 CICERO 2010 271 10 263 27.5% 0.87 (0.35;2.17) 0 EASY-MI 2010 53 0 52 Not estimable 7 Iversen 2011 16 170 0.38 (0.15;0.94) 185 55.5% 0 Thiele 2008 77 2 77 17.0% 0.19 (0.01;4.13) Total (95%) 586 562 100.0% 0.53 (0.29;0.99) 636 Total events 16 28 Heterogeneity: Chi 2 =2.58, df=2 (P=0.36);I 2 =2% Test for overall effect: Z=2.00 (P=0.05) 0.01 0.1 1 10 100 Favors IC Favors IV Navarese et al. Platelets 2011;1-8

  5. Background Study Design, Flow, and Compliance 2065 patients with suspected STEMI willing to participate Randomised (n=2065) Allocation Intravenous abciximab (n=1033) Intracoronary abciximab (n=1032) • Received intervention (n=993) • Received intervention (n=995) • Did not receive intervention (n=40) • Did not receive intervention (n=37) - STEMI not confirmed, no abciximab bolus (n=23) - STEMI not confirmed, no abciximab bolus (n=23) - emergency CABG, no abciximab bolus (n=8) - emergency CABG, no abciximab bolus (n=5) - exclusion criteria detected before or during PCI, no - exclusion criteria detected before or during PCI, no abciximab bolus (n=5) abciximab bolus (n=5) - technical problems with PCI, no abciximab bolus (n=4) - technical problems with PCI, no abciximab bolus (n=4) Follow-up Lost to follow-up (n=101) Lost to follow-up (n=97) - Withdrew informed consent (n=31) - Withdrew informed consent (n=33) - Lost to follow-up (n=15) - Lost to follow-up (n=17) - Incomplete documentation (n=15) - Incomplete documentation (n=10) - Premature study termination before receiving - Premature study termination before receiving abciximab bolus (n=40 – see description above) abciximab bolus (n=37 – see description above) Primary endpoint analysis Analyzed at 90-day follow-up (n=935) Analyzed at 90-day follow-up (n=932) Thiele et al. Lancet 2012;379:923-31

  6. Background Combined Clinical Endpoint p=0.54 Cumulative event free survival from congestive heart failure [%] death, reinfarction and Intracoronary Abciximab Intravenous Abciximab Time from randomization [days] Thiele et al. Lancet 2012;379:923-31

  7. Background Congestive Heart Failure p=0.03 Cumulative event free survival of Intracoronary Abciximab congestive heart failure [%] Intravenous Abciximab Time from randomization [days] Thiele et al. Lancet 2012;379:923-31

  8. AIDA STEMI CMR Substudy • CMR enables investigation of mechanistic and pathophysiological effects of intracoronary + intravenous abciximab application on myocardial damage and reperfusion injury. • To determine potential benefits of intracoronary abciximab application on infarct size, myocardial salvage, microvascular obstruction and ventricular function to further evaluate the benefit with respect to congestive heart failure. Thiele et al. Am Heart J 2010;159:547-554

  9. CMR Prognostic Implications Prognostic Prognostic Prognostic Prognostic Prognostic relevance relevance relevance relevance relevance validated validated partly validated validated partly validated Prognostic relevance Hemorrhage Myocardial salvage Microvascular obstruction Infarct size LV Volumes + Ejection fraction Desch et al. Trials 2011:12:e204-215

  10. Methods Study Organization and Study Sites Investigator Initiated Trial 22 study sites in Germany 8 CMR study sites CMR core laboratory: Ingo Eitel (Coordinator) Josephine Meissner Henning Sünkel Holger Thiele DSMB: Uwe Zeymer Hans-Richard Arntz Christoph Bode Karl Wegscheider Steering Committee: Holger Thiele Jochen Wöhrle Oana Brosteanu Gerhard Schuler CRO: Clinical Trial Center Leipzig

  11. Methods CMR Protocol Contrast- Injection 1,5 mmol/kg/BW Bolus Gd i.v. 35 40 0 5 10 15 20 25 30 Time Delayed T2 (min) Function Function enhancement SA 4CH+2 CH Short axes 4CH + 2CH + SA Survey Area at risk + late MO + Infarct size EF, EDV, ESV Hemorrhage Thiele et al. Am Heart J 2010;159:547-554

  12. Methods CMR Image Analysis Core laboratory assessed by blinded observers: • Edema • Hemorrhage • Endocardial contours • Epicardial contours • Infarct • Microvascular obstruction Area at risk = Volume Edema/Volume LV mass %Infarct Size = Volume Infarct/Volume LV mass %MO = MO-Volume/Volume LV mass %Hemorrhage = T2 hypointense core/Volume LV mass Myocardial salvage = Edema-Infarct Size Myocardial salvage index = Edema-Infarct Size/Edema Thiele et al. JACC 2010; 2010;55:2201-2209 Eitel et al. JACC 2010; 55:2470–2479

  13. Methods Study Design, Flow, and Compliance 2065 patients enrolled and randomly assigned No CMR (n=1270) 795 patients underwent CMR 401 assigned to intravenous 394 assigned to intracoronary abciximab abciximab Incomplete CMR scan Incomplete CMR scan - Scan terminated n=3 - Scan terminated n=4 - T2 poor image quality n=40 - T2 poor image quality n=39 - DE poor image quality n=10 - DE poor image quality n=7 Analyzed CMR data Analyzed CMR data - LV function n=394 - LV function n=401 - T2-weighted imaging n=355 - T2-weighted imaging n=361 - DE imaging n=387 - DE imaging n=391 - MO n=384 - MO n=390 - Hypointense core/Hemorrhage n=346 - Hypointense core/Hemorrhage n=353

  14. Results Patient Characteristics IC Abciximab (n=394) IV Abciximab (n=401) Age (years); median (IQR) 63 (51-71) 61 (51-71) Male sex; n (%) 287 (73) 316 (79) Current Smoking; n/total n (%) 161/364 (44) 178/363 (49) Hypertension; n/total n (%) 284/393 (72) 256/399 (64) Hypercholesterolemia; n/total n (%) 147/391 (38) 157/396 (40) Diabetes mellitus; n/total n (%) 87/392 (22) 73/400 (18) Body mass index (kg/m 2 ); median (IQR) 27.4 (24.9-30.1) 27.3 (24.8-30.5) Prior myocardial infarction; n/total n (%) 23/393 (6) 25/401 (6) Prior PCI; n/total n (%) 35/394 (9) 32/401 (8) Prior CABG; n/total n (%) 2/394 (1) 9/401 (2) Anterior myocardial infarction; n/total n (%) 180/382 (47) 183/376 (49) Creatinine clearance (ml/min); median (IQR) 92 (72-120) 96 (74-117) Symptom-onset - PCI hospital, median (IQR) 164 (108-300) 190 (110-335) Door-to-balloon-time; median (IQR) 30 (22-43) 29 (22-42) Killip-class on admission; n/total n (%) 1 341/394 (87) 358/401 (89) 2 35/394 (9) 24/401 (6) 3 11/394 (3) 9/401 (2) 4 7/394 (2) 10/401 (3)

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