Innovation Innovating to Win - - PowerPoint PPT Presentation

Revolutionizing Medical Device Innovation

Innovating to Win

http://www.symmetrymagazine.org/article/february-2011/crossing-the-valley-of-death The Valley of Death for Medical Devices

Innovating to Win

1) To build meaningful and productive collaborations with clinicians and companies 2) Reduce risk so companies pull technology out of UTD 3) Leverage small seed grants from center into federal funding (~25X ROI) 4) Create a reputation that results in partnerships with donors and companies 5) Create talent that can enter the biomedical engineering workforce 6) Increase research publications to add value to technology and center 7) Recruit talent to increase bandwidth and skill sets 8) Develop corporate and individual support to sustain activities

Technology Pathway

• $12 Million in External Funding
• DARPA, GlaxoSmithKlein, and NIH
• 40 Peer Reviewed Publications
• 4 Clinical Trials
• 8 Pre-clinical Trials
• 2 Commercial Devices Exiting this Year

Center Productivity 2012-2013

TxBDC Research Success (Years 3.0)

Twentieth century medical innovation changed the world by focusing on infectious disease.

Smallpox 400 million deaths Measles 97 million deaths Flu 76 million deaths Whooping cough 38 million deaths Tetanus 37 million deaths Meningitis 22 million deaths Hepatitis B 13 million deaths Diphtheria 1 million deaths Polio 0.1 million deaths

World Health Organization

World Health Organization

Chronic Pain 700 million Anxiety 650 million Depression 350 million Drug Addiction 185 million Severe Tinnitus 70 million Traumatic Brain Injury 54 million Epilepsy 50 million Alzheimer's Disease 36 million Autism 34 million Stroke 33 million Parkinson’s Disease 10 million

Twenty-first century innovation will change the world by focusing on brain disorders.

Diphtheria Tuberculosis Whooping Cough Yellow Fever Typhus Influenza Polio Japanese Encephalitis Anthrax Adenovirus Oral Polio Vaccine Measles Mumps Rubella Chicken Pox Pneumonia Meningitis Hepatitis B Influenza Hepatitis A Lyme Disease Rotavirus Papillomavirus

Present

Timeline of Vaccine Development

1921 1926 1932 1937 1945 1952 1954 1957 1962 1963 1967 1970 1974 1977 1978 1981 1985 1992 1998 2006

Technology Tipping Point

Young brains can change Adult brains can change

Brain stimulation changes the brain Plasticity rules discovered VNS-directed plasticity Tinnitus Therapy Developed First Human Clinical Trial Stroke Therapy Developed PTSD Therapy Developed First Human Stroke Trial TBI Therapy Developed US Clinical Trial for Tinnitus US Clinical Trail for Stroke SCI Therapy Developed Pain Therapy Developed US Clinical Trial MS and SCI Clinical Trial Chronic Pain US Clinical Trial PTSD

1977 1991 1998 2012 2003 2009 2013 2011 2014 2016 2017 2018 2019 2020 2021

Technology Tipping Point Future

Timeline of Targeted Plasticity Therapy

Miniaturized Wireless Implant By 2018 Outpatient Procedure

Therapeutic White Space

Duration Precision

Specific Circuit Whole Brain Minute Year

Drugs ECT DBS TMS

Brain Region Week

TPT Provides Specific and Long Lasting Changes in Function

Duration Precision

Specific Circuit Whole Brain Minute Year

Drugs ECT DBS TMS

Brain Region Week

TARGETED PLASTICITY

Use The Bodies Natural Pathway To Enhance Learning

Acetylcholine + Norepinephrine

Neural Plasticity

Locus Coeruleus VNS + Experience Nucleus Basalis Vagus Nerve

Stimulation of the Vagus Nerve Strengthens Active Circuits

VNS paired with Motor Rehab

VNS paired with Stroke Rehab Strengthens The Circuits Generating Those Movements

VNS paired with Stroke Rehab

These Brain Changes Lead to Motor Function Improvement

Aged Stroke Chronic Stroke

Unpublished Unpublished

Targeted Plasticity Therapy Enhances Motor Recover Following Stroke in Animals

TBI: Handle Pull Task * * *

Targeted Plasticity Therapy Enhances Motor Recover Following Stroke and TBI in Animals

TBI: Handle Pull Task

Targeted Plasticity Therapy Enhances Motor Recover Following Different Types of Strokes in Animals

Potential VNS-facilitated Therapies

• Tinnitus
• Communication disorders
• Chronic Pain
• Motor Impairments
• Cognitive Impairments
• PTSD / Anxiety

Tones + VNS Speech therapy + VNS Touch + VNS Skilled movement + VNS Cognitive therapy + VNS Desensitization therapy + VNS

Auditory Rehab Motor Rehab PTSD Rehab

Stroke Clinical Trials

Post VNS Therapy

Pre and 1 Month Post

Pre and 7 Months Post

https://vimeo.com/106525058 micro1

Innovations

https://vimeo.com/106525058 micro1

Reduce cost and size so it is minimally invasive and readily available. Provide from a non-profit

Innovations

Next Year

Flexible Electronics and Advanced Materials

Center Productivity 2012-2013

Innovations

Clinical Trial at UTSW Exiting the University This Year

Center Productivity 2012-2013

Innovations

PTSD with USC

page 31

VNS for Tinnitus Overview

The therapy pairs each tone played via headphones with a burst of vagus nerve stimulation. Over time, this will alter the neurons in the auditory cortex and reduce the perception of tinnitus in the patient.

Center Faculty Involved in Targeted Plasticity Initiative

Rob Rennaker, Ph.D. Mike Kilgard, Ph.D. Jane Wigginton, MD Diana Easton, Ph.D. Elliot Frohman, MD Ph.D. Teresea Frohman, PA-C Hunt Batjer, MD Seth Hays, Ph.D. Sven Vanneste, Ph.D. Christa McIntyre, Ph.D. Ted Price, Ph.D. Walter Voit, Ph.D. Shalini Prasad, Ph.D. Mario Romero-Ortega, Ph.D. Stuart Cogan, Ph.D. Patrick Ganzer, Ph.D. Dane Grasse, Ph.D. Director

• Assoc. Director

Chief Medical Officer Director of Regulatory Affairs MS MS Neurosurgeon Stroke and Parkinson’s Disease Tinnitus Post-Traumatic Stress Disorder Chronic Pain Materials Science Sensory Technology Peripheral Nerve Injury Biomedical Devices Spinal Cord Injury Wireless Implant Technology