Information Theory and Sequence Logos Yosi Shibberu Rose-Hulman - - PowerPoint PPT Presentation

SLIDE 1

Information Theory and Sequence Logos

Yosi Shibberu Rose-Hulman Institute of Technology 2014

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 2

What are Sequence Logos?

Insulin

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 3

What are Sequence Logos?

Insulin Sequence

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 4

What are Sequence Logos?

Insulin Sequence for 11 Species

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 5

What are Sequence Logos?

Insulin Sequence Logo for 11 Species

weblogo.berkeley.edu

1 2 3 4 bits N 1

M

2

T

A

3 S

P

L

4

L

W

5 A

T

M

6

A

R

7

L

8

L

9

P

10

L

11

L

12 V

T

A

13

F

L

14

L

15 S I

V

A

16

L

17

L C

W

18 R

I A

E

G

19

L

P

20 S N

A

D

21

P

22

T

A

23

S P H R A

Q

24

A

25

F

26

V

27

N

28

Q

29

H

30

L

31

C

32

G

33

S

34

H

35

L

36

V

37

E

38

A

39

L

40

Y

41

L

42

V

43

C

44

G

45

E

46

R

47

G

48

F

49

F

50

Y

51

T

52

P

53

K

54 F

A

S

T

55

R

56

R

57

G

E

58

V A

59

D

E

60

E

D

61 Q

P

L

62

Q

63 M

G

V

64 R P K A

G

65

D

Q

66

L A

V

67

E

68

L

69

A

G

70

E

G

71 S

A

G

72

P

73

G

74

E

A

75

D

G

76 L

D G

S

77

P

L

78

R

Q

79

T A

P

80

S

L

81

A

82

L

83

E

84 M L A

V

G

85 P

S A

86 R Q

L

87

Q

88

K

89

R

90

G

91

I

92

V

93

D

E

94

Q

95

C

96

C

97

A

T

98

G

S

99

V

I

100

C

101

S

102

L

103

Y

104

Q

105

L

106

E

107

H

N

108

Y

109

C

110

N

C

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 6

What are Sequence Logos?

Insulin Sequence Logo for 11 Species

weblogo.berkeley.edu

1 2 3 4 bits N 1

M

2

T

A

3 S

P

L

4

L

W

5 A

T

M

6

A

R

7

L

8

L

9

P

10

L

11

L

12 V

T

A

13

F

L

14

L

15 S I

V

A

16

L

17

L C

W

18 R

I A

E

G

19

L

P

20 S N

A

D

21

P

22

T

A

23

S P H R A

Q

24

A

25

F

26

V

27

N

28

Q

29

H

30

L

31

C

32

G

33

S

34

H

35

L

36

V

37

E

38

A

39

L

40

Y

41

L

42

V

43

C

44

G

45

E

46

R

47

G

48

F

49

F

50

Y

51

T

52

P

53

K

54 F

A

S

T

55

R

56

R

57

G

E

58

V A

59

D

E

60

E

D

61 Q

P

L

62

Q

63 M

G

V

64 R P K A

G

65

D

Q

66

L A

V

67

E

68

L

69

A

G

70

E

G

71 S

A

G

72

P

73

G

74

E

A

75

D

G

76 L

D G

S

77

P

L

78

R

Q

79

T A

P

80

S

L

81

A

82

L

83

E

84 M L A

V

G

85 P

S A

86 R Q

L

87

Q

88

K

89

R

90

G

91

I

92

V

93

D

E

94

Q

95

C

96

C

97

A

T

98

G

S

99

V

I

100

C

101

S

102

L

103

Y

104

Q

105

L

106

E

107

H

N

108

Y

109

C

110

N

C

signal peptide chain B C peptide chain A 31 43 95 96 100 109

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 7

What are Sequence Logos?

Insulin Sequence Logo for 11 Species

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 8

What are Sequence Logos?

Module Materials Videos (7 approx 10 min each) Handouts (with space for solutions to examples) Lessons (3 with solutions for instructors)

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 9

What are Sequence Logos?

Screenshot of a Video

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 10

What are Sequence Logos?

Handouts

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 11

What are Sequence Logos?

Lessons

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 12

What are Sequence Logos?

Student Project (Steven Haussmann)

Insulin Structure Color Coded by Information Content

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13

SLIDE 13

What are Sequence Logos?

Acknowledgements

Mark Brandt, Chemistry & Biochemistry Dept. Nathanael Moore, CS Senior Andrew Piliser, Math Senior Rain Dartt, Computer Engineering Junior Steven Gregory, Chemistry Freshman

Yosi Shibberu () Information Theory and Sequence Logos Rose-Hulman Institute of Technology 2014 / 13