Information Theory and Sequence Logos Yosi Shibberu Rose-Hulman Institute of Technology 2014 Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Insulin Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Insulin Sequence Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Insulin Sequence for 11 Species Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Insulin Sequence Logo for 11 Species 4 3 M L L P L L L L P A F V N Q H L C G S H L V E A L Y L V C G E R G F F Y T P K R R Q E L P G A L E Q K R G I V Q C C C S L Y Q L E Y C N bits A W R L P E G G A G L Q E T S I N A E D Q L 2 L M A W A V G P L A D L V A 1 G T G S G V S T V E A Q S P G A A A G V 0 T P S L A A T V F I C L A I L N T A H R A G D E Q M K P D L A E S E D D P R T A S L A P R Q D A G V H 1 2 3 4 5 6 7 8 9 10 11 12 13 14 S 15 16 17 R 18 19 S 20 21 22 S P 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 F 54 55 56 57 58 59 60 61 62 63 R 64 65 66 67 68 69 70 71 72 73 74 75 L 76 77 78 79 80 81 82 83 M 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 N C weblogo.berkeley.edu Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Insulin Sequence Logo for 11 Species 31 43 95 96 100 109 4 M L L P L L L L P A F V N Q H L C G S H L V E A L Y L V C G E R G F F Y T P K R R Q E L P G A L E Q K R G I V Q C C C S L Y Q L E Y C N 3 A W R L P E G G A G L Q E T S I N L A W A E D Q P L L bits M A V 2 L V G A D A G T G S G 1 V S T V A Q S P A A G T P L A T F I C E A L N T R A A G D E G K P A D L A E E D D P R A S A V Q D A G V H 0 1 2 S 3 4 A 5 6 7 8 9 10 11 V 12 13 14 S 15 16 L 17 R I 18 19 S 20 21 22 P H S 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 F 54 55 56 57 58 59 60 Q 61 62 M 63 R 64 65 66 67 68 69 70 S 71 72 73 74 75 L 76 77 78 T 79 80 81 82 83 L M 84 P 85 R 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 N C weblogo.berkeley.edu signal peptide chain B C peptide chain A Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Insulin Sequence Logo for 11 Species Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Module Materials Videos (7 approx 10 min each) Handouts (with space for solutions to examples) Lessons (3 with solutions for instructors) Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Screenshot of a Video Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Handouts Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Lessons Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Student Project (Steven Haussmann) Insulin Structure Color Coded by Information Content Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
What are Sequence Logos? Acknowledgements Mark Brandt, Chemistry & Biochemistry Dept. Nathanael Moore, CS Senior Andrew Piliser, Math Senior Rain Dartt, Computer Engineering Junior Steven Gregory, Chemistry Freshman Rose-Hulman Institute of Technology 2014 Yosi Shibberu () Information Theory and Sequence Logos / 13
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