Incremental shuttle walking test predicts survival in non-group 1 - - PowerPoint PPT Presentation

Background

• 6-MWT is a widely used sub-maximal walking test in pulmonary

hypertension

• ISWT externally paced incremental exercise test1
• Previously shown that ISWT distance predicts survival in Group 1 PAH 2

Methods

• Data from ASPIRE registry
• ISWT within 3/12 of RHC
• Treatment naïve and have non-group 1 pulmonary hypertension

Incremental shuttle walking test predicts survival in non-group 1 pulmonary hypertension without a ceiling effect

• 1. Singh S et al, Thorax 2008 2. Billings CG et al, J Heart and Lung Transplant 2017
• C. Billings1, R. Lewis1, J. Hurdman1, I. Armstrong1, I. Smith1, M. Austin1, C. Elliot1, A. Charalampopoulos1, I. Sabroe1, A. Lawrie2, R. Thompson2, R. Condliffe1, D. Kiely1

1 Sheffield Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital - Sheffield (United Kingdom), 2 Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School - Sheffield (United Kingdom)

Billings CG, Lewis R et al,

Results

Incremental shuttle walking test predicts survival in non-group 1 pulmonary hypertension without a ceiling effect

Band 1 ISWD m: 0-30; Band 2: 40-120; Band 3: 130-250; Band 4: 260-420; Band 5: 430 - 1020

n 1 year mortality % ISWD (m) 0-120 248 20.2 130-420 203 9.4 >420 28 ISWD (%pred) 0-20 248 21.1 >20-60 212 8.0 >60 21

Band 1 Band 2 Band 3 Band 4 Band 5

Conclusion

• ISWD and ISWD%pred correlates with symptoms and haemodynamics
• ISWD predicts survival in non-group 1 PH
• Can be used to risk stratify patients
• Provides an alternative field walking test to 6MWT

Robert Lewis was fully funded to attend the ERS by Pulmonary Vascular Research Institute

Incremental shuttle walking test predicts survival in non-group 1 pulmonary hypertension without a ceiling effect