SLIDE 1
4/21/2018 1
Loss of reversibility in flow-induced pulmonary arterial hypertension is associated with a senescent vascular phenotype
Diederik van der Feen, MD
Network Pediatric Pulmonary Hypertension
University Medical Center Groningen -Center for Congenital Heart diseases
Increased flow & pressure are the essential triggers
University Medical Center Groningen Center for Congenital Heart diseases Dickinson, AJP 2013; van der Feen, Eur Heart J 2017 University Medical Center Groningen Center for Congenital Heart diseases
Normalisation of Flow (Haemodynamic Unloading) reverses PAH-CHD… …but not after a certain point of no return.
van der Feen, Eur Heart J 2017
Clinical Problems
University Medical Center Groningen Center for Congenital Heart diseases
It has been difficult to ascertain: When PAH-CHD becomes irreversible
- How can we recognize reversibility?
Why PAH-CHD becomes irreversible
- Why does the one patient with PAH-CHD reverse after HU and the other not?
and Opportunities
- Study the mechanisms that orchestrate the transition to irreversible PAH.