The Impo portance ance and Safet ety of of High gh-Do Dose
1950’s – Misdiagnosis of Williams Syndrome • A deletion on 26 genes occurring in 1 in 7000 births • Results in hypercalcemia and high levels of Vitamin D • Correctly diagnosed in the 60’s…but it was too late: • The reputation of vitamin D has remained tainted for 50+ years • To this day, doctors rarely consider even trying more than 2,000 IU daily • The importance of enough vitamin D might have been left undiscovered… • Were it not for the global emergence of vitamin D deficiency syndromes • “I have since learned that there is little concern at 10,000 IU and the toxic level for long term use is about 40,000 IU daily.” - John Cannell, M.D. Founder of the Vitamin D Council
22 o 22 of t the 38 R 38 Reas ason ons for or Vi Vitamin D D De Deficien ency Are NEW!
Epi Epidemic c Vi Vitamin D D Defici ciency ! Why? https://vitamindwiki.com/tiki-index.php?page_id=1586
My Myth-Understandings about “vitamin” D Myth - Spend 10-15 minutes in the sun three times a week and your vitamin D will be fine. Myth - Eat fish three times a week and your vitamin D will be adequate Myth - Can get all your vitamin D needs from food Myth - Drink a cup of milk every day and your vitamin D will be okay Myth - A daily multivitamin will meet your vitamin D needs Myth - You do not develop vitamin D deficiency if you live in a warm, sunny place Myth - Eating a healthy diet will take care of your vitamin D needs as well Myth - More Kidney stones if you take more vitamin D Myth - Need lots of Calcium while getting lots of vitamin D ( just the opposite actually) Myth - No tan is a safe tan (“skin cancer can happen in just a few minutes”) Myth - If I sunburn easily, I need to stay out of the sun (easy sun burning = severe D deficiency) Myth - Should reduce cholesterol ( no, increase cholesterol - to produce vitamin D) Myth - Sunlight alone causes skin cancer (melanoma often occur where the sun does not shine) Myth - Can get enough vitamin D from the sun to last you thru the winter Myth - Can get enough vitamin D even if wearing lots of sunscreen
Therapeutic Vitamin D3:K2 Riordan 3 Targeted Dose Monitoring Protocol Level 2 Optimal Dose Foundation Dose Vitamin Dose
Think in 4 Levels: Is D a vitamin 3 D is a receptor-modulator ? Level 2 D is a KEY cell-enabler D is a hormone D is a vitamin
1913 – The Birth of the “Vitamin Concept” Level 0 D < ----- Rickets (200iu) Vitamin C Scurvy Vitamin B Vitamin A
1937 Level 1 Discovery: D is made in the skin with UVB light!
D is a hormone synthesized in the body Level 1 3 D is a receptor-modulator Level 2 D is a KEY cell-enabler D is a hormone D is a vitamin
D D is a hormone 1 Endocrinology 30,000iu
D ? iu 2
D 1 3 500iu Pre- D
D D 3 500iu 200iu D 3 4 Pre- D 1300iu
D 25(OH)D 3 5 ? iu D 3 200iu D 3 ? iu ? iu
D 6 1 25(OH)D 3 5 3 2 D 3 500iu 200iu D 3 4 Pre- D 1300iu
D 6 25(OH)D 3 Calcidiol 1-25(OH) 2 D 3 Calcitriol
6 1 25(OH)D 3 5 3 2 D 3 500iu 200iu D 3 4 1-25(OH) 2 D 3 Pre- D Calcitriol 1300iu
D Ca 7 1-25(OH) 2 D 3 Calcitriol
D 25(OH)D 3 Ca 7 D 3 500 200 D 3 Pre- D 1-25(OH) 2 D 3 Calcitriol 1300
PTH When 25(OH)D3 goes UP… Calcitriol goes UP… 8 Calcium absorption from gut goes UP… Parathyroid hormone goes DOWN… Ca Serum calcium is regulated by… BOTH 1-25(OH) 2 D 3 25(OH)D3 AND PTH Calcitriol
D P PTH Ca 8 Parathyroid Cells Job : Monitor Calcium Ca If Calcium goes UP 7 PTH *** Make LESS 1-25(OH) 2 D 3 ***Absorb LESS Calcitriol calcium from bone & gut
D P PTH Ca 8 Parathyroid Cells Job : Monitor Calcium Ca If Calcium goes Down 7 ***Make MORE PTH 1-25(OH) 2 D 3 ***Absorb MORE Calcitriol calcium from bone & gut
6 1 PTH 25(OH)D 3 5 8 Ca 3 7 2 D 3 500iu 200iu D 3 4 1-25(OH) 2 D 3 Pre- D Calcitriol 1300iu
D PTH 25(OH)D 3 Ca D 3 500iu 200iu D 3 1-25(OH) 2 D 3 Pre- D Calcitriol 1300iu
Therapeutic Vitamin D3:K2 Riordan 3 Targeted Dose Monitoring Protocol Level 2 Optimal Dose Foundation Dose Vitamin Dose
D 3 is a hormone synthesized in the body Level 2 3 D is a receptor-modulator Level 2 D is a KEY cell-enabler D is a hormone D is a vitamin
The vitamin D FUNDAMENTALS hormone OF VITAMIN D HORMONE- 1,25(OH) 2 D 3 REGULATED GENE exerts its diverse EXPRESSION biological effects J Steroid Biochemical in target tissues Molecular by regulating Biology 2014 gene expression
25(OH)D Acts as a Cellular Function Enabler Stimulus Response
Autocrinology Epigenetic… Dynamic DNA
…to LOW Serum Calcium Ca Parathyroid Cell
Parathyroid Cell Ca
Parathyroid Cell Ca ? ? ?
Parathyroid Cell Ca ? ? ? PTH
Low Parathyroid Cell Calcium Ca PTH
If Intracellular Calcitriol is LOW, the response is weak Low Parathyroid Cell Calcium Ca PTH PTH
Low Parathyroid Cell Calcium Ca PTH
25(OH)D Acts as a Cellular Function Enabler Stimulus 1,25(OH) 2 D 3 Calcitriol Proper Response
25(OH)D Acting as a Robust Levels of Cellular Function Enabler 25(OH)D 3 1-25(OH) 2 D 3 Vibrant Response
25(OH)D Acting as a D 3 Deficiency Syndrome Cellular Function Enabler 25(OH)D 3 1-25(OH) 2 D 3 Weak Response
Therapeutic Vitamin D3:K2 Riordan 3 Targeted Dose Monitoring Protocol Level 2 Optimal Dose Foundation Dose Vitamin Dose
Optimal M Metabolism/Weight L Loss Prog ogram CRP-hs, Thyroid Profile: TSH, FT3, and FT4, Vitamin D, Lipid Profile, and Chem Profile/CBC
Mike Shaw, PA-C Wichita
D 3 modulates VDR Receptors Level 3 3 D is a receptor-modulator Level 2 D is a KEY cell-enabler D is a hormone D is a vitamin
Therapeutic Vitamin D3:K2 Riordan 3 Targeted Dose Monitoring Protocol Level 2 Optimal Dose Foundation Dose Vitamin Dose
Ryan Hartig, M.D. Gael Wheeler, D.O. Wichita Overland Park
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