How to print organ? How to print organ? Vladimir Mironov MD, PhD - - PowerPoint PPT Presentation

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How to print organ? How to print organ? Vladimir Mironov MD, PhD - - PowerPoint PPT Presentation

Feb 14, 2024 345 likes •659 views

How to print organ? How to print organ? Vladimir Mironov MD, PhD Vladimir Mironov MD, PhD Director of Director of MUSC Bioprinting Bioprinting Center Center MUSC Medical University of South Carolina Medical University of South Carolina

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How to print organ? How to print organ?

Vladimir Mironov MD, PhD Vladimir Mironov MD, PhD Director of Director of MUSC MUSC Bioprinting Bioprinting Center Center Medical University of South Carolina Medical University of South Carolina Charleston, South Carolina, USA Charleston, South Carolina, USA

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Kidney price: $30, Kidney price: $30,000.00 .00

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Tissue assembly technologies Tissue assembly technologies

  • 1. Rolling
  • 1. Rolling
  • 2. Embedding
  • 2. Embedding
  • 3. Seeding
  • 3. Seeding
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How to print organ? How to print organ?

Part I. Part I. Engineering Engineering aspects aspects

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What is organ printing? What is organ printing?

Automatic computer Automatic computer-

  • aided

aided layer by layer deposition layer by layer deposition of

  • f

living and biologically relevant living and biologically relevant materials with purpose of rapid materials with purpose of rapid manufacturing of functional manufacturing of functional human organ human organ

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Computer Computer-

  • assisted

assisted prototype polymer scaffold printing prototype polymer scaffold printing

Therics Therics Inc, NJ, USA Inc, NJ, USA Rapid prototyping technology Rapid prototyping technology

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Organ printing technology Organ printing technology

nScript nScript Inc.(Sciperio Inc.(Sciperio), USA ), USA Organ printing technology Organ printing technology

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Three Main Steps in Three Main Steps in Organ Printing Technology Organ Printing Technology

  • 1. Preprocessing
  • 1. Preprocessing

(CAD, blueprints, preconditioning) (CAD, blueprints, preconditioning)

  • 2. Processing
  • 2. Processing

(actual printing, solidification) (actual printing, solidification) 3.

  • 3. Postprocessing

Postprocessing (perfusion, (perfusion, postconditioning postconditioning, , accelerated tissue maturation) accelerated tissue maturation)

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How to print organ? How to print organ?

  • 1. Preprocessing
  • 1. Preprocessing

(CAD, blueprints, preconditioning) (CAD, blueprints, preconditioning)

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Blueprint for Heart Blueprint for Heart

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Blueprints for Vasculature Blueprints for Vasculature

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Blueprint for Vasculature Blueprint for Vasculature

According to TissueInformatics, Inc.

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Blueprint for Vasculature Blueprint for Vasculature

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Blueprint for Vasculature Blueprint for Vasculature

(from R. Karch et al., 1999, 2000)

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How to print organ? How to print organ?

  • 2. Processing
  • 2. Processing

(actual printing, solidification) (actual printing, solidification)

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Bioprinter Bioprinter is probably not a big problem ... is probably not a big problem ...

Therics Therics Envisiontech Envisiontech Sciperio Sciperio Sandia Sandia NL NL Canon, Epson, Canon, Epson, HP, Lexmark HP, Lexmark Neatco Neatco

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Neatco Neatco Inc. Canada

  • Inc. Canada
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Methods of Dispensing Methods of Dispensing

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Modeling of Printed Vascular Unit Modeling of Printed Vascular Unit

V A

Sometimes modeling Sometimes modeling is not a bad idea... is not a bad idea...

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Roadmap for organ printing Roadmap for organ printing

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How to print organ? How to print organ?

  • 3. Postprocessing
  • 3. Postprocessing

(perfusion, accelerated tissue maturation, (perfusion, accelerated tissue maturation, postconditioning postconditioning) )

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Perfusion bioreactor Perfusion bioreactor

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… …one of “Six technologies that will change the world”

  • ne of “Six technologies that will change the world”

…at least according to magazine “Business -2.0”

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Organ Printing Technology Organ Printing Technology

Printing of living organs Printing of living organs will be another pioneering will be another pioneering step in the history of science, step in the history of science, technology and civilization technology and civilization

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Bioprinting Bioprinting in 2024 in 2024

Here is what Michael Dell (Dell Inc) said in his speech at Hitotsubashi University, Japan (24 May 2004): (Micheal Dell started his company when he was 19 years old student with only $1,000

  • cash. 20 years later Dell Inc is one of fastest growing $50bln company with $14bln cash)

Question:

"How could you imagine yourself, your company in 2024?"

Michael Dell’s answer:

”… I think certainly by the time there will be a whole new industry as you combine the physical sciences and the biological sciences and we don't quite know what that will look like, but I think it's an incredible opportunity to change medicine and health. That brings me back to what I started to study in college, to be a doctor”.