How the DMM- AAI pr e dic ts br ain and be havior al r e sponse - - PowerPoint PPT Presentation

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How the DMM- AAI pr e dic ts br ain and be havior al r e sponse s of mothe r s and the ir infants L ane Str athe ar n, MBBS, PhD Unive rsity of Iowa , USA la ne - stra the a rn@uiowa .e du the inte rna tio na l a sso c ia tio n fo

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SLIDE 1

How the DMM- AAI pr e dic ts br ain and be havior al r e sponse s

  • f mothe r

s and the ir infants

L ane Str athe ar n, MBBS, PhD

Unive rsity of Iowa , USA la ne - stra the a rn@uiowa .e du

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SLIDE 2

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 3

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 4

MOTOR OUTPUT

(e.g. caregiving behavior)

SENSORY INPUT

(e.g. child face/cry cues)

Ne ur

  • biology of mate r

nal c ar e giving

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 5

MOTOR OUTPUT

(e.g. caregiving behavior)

SENSORY INPUT

(e.g. child face/cry cues)

Ne ur

  • biology of mate r

nal c ar e giving

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

slide-6
SLIDE 6

+ +/-

MOTOR OUTPUT

(e.g. caregiving behavior)

Mesocorticolimbic Dopamine Pathway: “Reward” VENTRAL STRIATUM VENTRAL TEGMENTAL AREA

SENSORY INPUT

(e.g. child face/cry cues)

VENTROMEDIAL PREFRONTAL CORTEX ENDOGENOUS OXYTOCIN HYPO- THALAMUS

Ne ur

  • biology of mate r

nal c ar e giving

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 7

+ +/-

MOTOR OUTPUT

(e.g. caregiving behavior)

Nigrostriatal Dopamine Pathway: “Habit Formation” Mesocorticolimbic Dopamine Pathway: “Reward” VENTRAL STRIATUM SUBSTANTIA NIGRA VENTRAL TEGMENTAL AREA

SENSORY INPUT

(e.g. child face/cry cues)

+/-

DORSOLATERAL PREFRONTAL CORTEX VENTROMEDIAL PREFRONTAL CORTEX DORSAL STRIATUM

+ +

ENDOGENOUS OXYTOCIN HYPO- THALAMUS

Ne ur

  • biology of mate r

nal c ar e giving

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

slide-8
SLIDE 8

+ +/-

MOTOR OUTPUT

(e.g. caregiving behavior)

Nigrostriatal Dopamine Pathway: “Habit Formation” Mesocorticolimbic Dopamine Pathway: “Reward” VENTRAL STRIATUM SUBSTANTIA NIGRA VENTRAL TEGMENTAL AREA

SENSORY INPUT

(e.g. child face/cry cues)

+/-

AMYGDALA DORSOLATERAL PREFRONTAL CORTEX VENTROMEDIAL PREFRONTAL CORTEX DORSAL STRIATUM

+ +

ENDOGENOUS OXYTOCIN HYPO- THALAMUS

Ne ur

  • biology of mate r

nal c ar e giving

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 9

mPFC

y=11 x=-6

Own Happy F ac e s: T ype B vs. T ype A

  • 1

1 2 3 4 5

Secure Insecure/Dismissing % Signal Change

  • 1.5
  • 1
  • 0.5

0.5 1 1.5

Secure Insecure/Dismissing % Signal Change (se=1.0, t=3.0, p=0.006) (se=0.4, t=3.1, p=0.005)

Bila te ra l Ve ntra l Stria tum Rig ht Me dia l PF C

Stra the a rn e t al. Ne uro psyc ho pharmac o lo g y (2009)

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

MEDIAL PREFRONTAL CORTEX

VENTRAL STRIATUM

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SLIDE 10
  • 0.4
  • 0.2

0.2 0.4 0.6 0.8 1 1.2

Secure Insecure/Dismissing % Signal Change

y=11 x=-6

VS

  • 0.6
  • 0.4
  • 0.2

0.2 0.4 0.6 0.8 1 1.2 1.4

Secure Insecure/Dismissing % Signal Change

y=11

Insula

y=17

R Ve ntra l Stria tum R I nsula

(se=0.4, t=3.1, p=0.005) (se=1.0, t=3.0, p=0.006)

Stra the a rn e t al. Ne uro psyc ho pharmac o lo g y (2009)

Own Sad F ac e s: T ype B vs. T ype A

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

VENTRAL STRIATUM

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SLIDE 11
  • I

nc lude s o c c urre nc e s o f c hildho o d a b use , ne g le c t, o r de a th o f a pa re nt

  • Curre nt disc o urse fro m Adult

Atta c hme nt I nte rvie w indic a te s tha t the tra uma ha s no t b e e n a de q ua te ly pro c e sse d, a nd c o ntinue s to inte rfe re with c urre nt func tio ning

Unr e solve d tr auma in mothe r s

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 12

R y = -5

0.5 0.6 0.7 0.8 0.9 1.0 1.1

Happy Sad

  • B. Unresolved

trauma

  • A. No trauma

0.5 0.6 0.7 0.8 0.9 1.0 1.1

Happy Sad

Amygdala BOLD Signal Change (Estimated Marginal Means)

**

Own Unknown Infant Identity

Infant Affect

Amygdala ac tivation to infant distr e ss in mothe r s with unr e solve d tr auma

Amygdala

K im e t al. So c ial Ne uro sc ie nc e (2014)

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

AMYGDALA

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SLIDE 13
  • 98% o f study mo the rs with

a ddic tio n pro b le ms a lso ha d unre so lve d tra uma (vs. 67% o f c o ntro l g ro up; p<0.001)

Unr e solve d tr auma in addic te d mothe r s

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 14

Addicted Mothers (n=39) Normative Mothers (n=36)

VENTRAL STRIATUM VENTRO- MEDIAL PFC

  • 0.4
  • 0.2

0.2

  • 2

2 4 6 8

Time (sec)

  • 0.4
  • 0.2

0.2

  • 2

2 4 6 8

Time (sec)

  • 0.2
  • 0.1

0.1 0.2 0.3

  • 2

2 4 6 8

Time (sec)

  • 0.2
  • 0.1

0.1 0.2 0.3

  • 2

2 4 6 8 Time (sec)

>

Own-Happy Unknown-Happy

K im, S., Iye ng a r, U., Ma ye s, L . C., Po te nza , M. N., Ruthe rfo rd, H. J. V., & Stra the a rn, L . (2017). Human Brain Mapping , 38(11), 5421-5439.

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

slide-15
SLIDE 15

VENTRAL STRIATUM VENTRO- MEDIAL PFC

y = 7

  • 0.4
  • 0.2

0.2

  • 2

2 4 6 8

Time (sec)
  • 0.4
  • 0.2

0.2

  • 2

2 4 6 8

Time (sec)

x = -16

  • 0.2
  • 0.1

0.1 0.2 0.3

  • 2

2 4 6 8

Time (sec)

x = -7

  • 0.2
  • 0.1

0.1 0.2 0.3

  • 2

2 4 6 8 Time (sec)

y = 7

>

Own-Happy Unknown-Happy

Addicted Mothers (n=39) Normative Mothers (n=36)

K im, S., Iye ng a r, U., Ma ye s, L . C., Po te nza , M. N., Ruthe rfo rd, H. J. V., & Stra the a rn, L . (2017). Human Brain Mapping , 38(11), 5421-5439.

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 16
  • Ra ndo mize d c o ntro lle d tria ls o f

intra na sa l o xyto c in

  • Mo the rs with a ddic tio n
  • Po st-na ta l de pre ssio n
  • Mo the rs with inse c ure a tta c hme nt

Whe r e to fr

  • m he r

e ?

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 17

+ +/-

MOTOR OUTPUT

(e.g. caregiving behavior)

Nigrostriatal Dopamine Pathway: “Habit Formation” Mesocorticolimbic Dopamine Pathway: “Reward” VENTRAL STRIATUM SUBSTANTIA NIGRA VENTRAL TEGMENTAL AREA

SENSORY INPUT

(e.g. child face/cry cues)

+/-

AMYGDALA DORSOLATERAL PREFRONTAL CORTEX VENTROMEDIAL PREFRONTAL CORTEX DORSAL STRIATUM

+ +

ENDOGENOUS OXYTOCIN HYPO- THALAMUS

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

slide-18
SLIDE 18

+ +/-

MOTOR OUTPUT

(e.g. caregiving behavior)

Nigrostriatal Dopamine Pathway: “Habit Formation” Mesocorticolimbic Dopamine Pathway: “Reward” VENTRAL STRIATUM SUBSTANTIA NIGRA VENTRAL TEGMENTAL AREA

SENSORY INPUT

(e.g. child face/cry cues)

+/-

AMYGDALA DORSOLATERAL PREFRONTAL CORTEX VENTROMEDIAL PREFRONTAL CORTEX DORSAL STRIATUM

+ +

ENDOGENOUS OXYTOCIN HYPO- THALAMUS

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

INTRANASAL OXYTOCIN

+

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SLIDE 19

Oxytocin Placebo

Normative Mothers (n=10)

VENTRAL/ DORSAL STRIATUM VENTRAL TEGMENTAL AREA (VTA) AMYGDALA

Oxytoc in inc re a se s re wa rd a nd a myg da la re sponse to infa nt fa c e s

>

Own-Happy Unknown-Happy

the inte rna tio na l a sso c ia tio n fo r the stud y o f a tta c hme nt

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SLIDE 20

F rankfurt, 2012 Camb ridg e , 2010 Be rtino ro , 2008 Miami, 2015

T

  • download pr
  • gr

am mate r ials, c lic k he r e

https:/ / www.ia sa - dmm.org / ia sa - c onfe re nc e /