Histopathology Luis Beltran Royal London Hospital Barts Health

Histopathology • What do Histopathologists do? • Why are we important? • TNM and grading

Histopathology

Histopathology • Haematoxylin and eosin (H&E): gold standard • Subjective interpretation • Grey areas • Inter and intrapersonal variations

Histopathology • Diagnosis • Prognosis • Response to targeted therapies • Immunohistochemistry • FISH • PCR

Histopathology. TNM. • Staging system for all solid tumours was devised by Pierre Denoix between 1943 and 1952 • Developed and maintained by the International Union Against Cancer (UICC) to achieve consensus on one globally recognised standard for classifying the extent of spread of cancer. • Also used by the American Joint Committee On Cancer (AJCC) and the International Federation of Gynaecology and Obstetrics (FIGO). • In 1987, the UICC and AJCC staging systems were unified into a single staging system.

Histopathology. TNM. Cancer staging system that describes the extent of cancer in a patient’s body. T describes the size of the tumour and whether it has invaded  nearby tissue, N describes status of regional lymph nodes ,  M describes distant metastases .  Prefix modifiers c : stage given by clinical examination of a patient. The c-prefix is  implicit in absence of the p-prefix p : stage given by pathologic examination of a surgical specimen  y : stage assessed after treatment i.e. chemotherapy and/or  radiation therap y ; in other words, the individual had neoadjuvant therapy r : stage for a recurrent tumor in an individual that had some  period of time free from the disease. a : stage determined at autopsy. 

Histopathology. TNM. • G (1 – 4): the grade: grade of differentiation • R (0/1/2): the completeness of the resection/ residual tumour • L (0/1): invasion of lymphatic vessels • V (0/1/2): invasion into vein • C (1 – 5): a modifier of the certainty (quality) of the last mentioned parameter

Histopathology. TNM.

Histopathology

Histopathology. Immunohistochemistry.

Histopathology. Grade.

Histopathology Any questions?

Histopathology Luis Beltran Royal London Hospital Barts Health - PowerPoint PPT Presentation

Histopathology Luis Beltran Royal London Hospital Barts Health Histopathology What do Histopathologists do? Why are we important? TNM and grading Histopathology Histopathology Histopathology Histopathology Histopathology

Diagnostic studies Diagnostic studies (histopathology & PCR) (histopathology & PCR)

The Changes to Come: A Trainees Perspective Dr Sarah Harris ST4 Histopathology West of

Bag-of-Visual-Ngrams for Histopathology Image Classification opez-Monroy, M.Sc. 1 A. Pastor L

Histopathology reporting of liver resection specimens for metastatic colorectal carcinoma:

Deep Learning for Magnification Independent Breast Cancer Histopathology Image Classification

Histopathology of AKI Peter Boor pboor@ukaachen.de Pathology & Nephrology RWTH Aachen,

DEPARTMENT OF PATHOLOGY List of UG Class slides S.No Slides Histopathology Slides Fatty Change

Transfer Learning for Cell Nuclei Classification in Histopathology Images Neslihan Bayramoglu,

Caitlin Reid Rudi Schmigylski Dumfries and Galloway Royal Infirmary Histopathology dept moved

2015 Prostate Re-audit: Assessment of Prostate Biopsy Histology Concordance with RVI MDT Review

NIFTP: Histopathology of a Cytological Monkey Wrench B. Wehrli Non-Invasive Encapsulated

28/04/2020 About me Professional Registration with the Science Council Biomedical Scientist

GENES AS POTENTIAL DRUG TARGETS Sciences AGAINST TUBERCULOSIS USING University of PULMONARY

vie w Principies of MHC class 1-mediated antigen presentation and T cell selection H.-G. Ljunggren

Salivary Gland Neoplasms Sam J. Cunningham, MD, PhD Faculty Advisor: Shawn D. Newlands, MD, PhD

Invited Review Principles of MHC class I-mediated antigen presentation and T cell selection

Waseem Jugon & Mijanur Rahman Disclaimer The views expressed in this paper are those of the

By The Life Raft Group What is cancer? Cancer consists of over 100 diseases. Cancer begins

Confirmatory subgroup analyses: Case Studies Frank Bretz, Gerd Rosenkranz, Emmanuel Zuber EMA

Neoadjuvant Hemithoracic Intensity Modulated RT: The SMART Approach for Malignant Pleural

A Contemporary View of Lumpectomy Margin Evaluation Stuart J. Schnitt, M.D. Department of

Cue Based Feeding in the NICU ANNA ELSENBROCK, MS, OTR/L, CPST, CNT LAURA LUCAS, MS, RD, CSP, LD

Organ failure scores in Organ failure scores in neonatal sepsis. neonatal sepsis. Hugo

+ Agenda 2 2 Infant Mortality Statistics MDCH Dashboard 1. History of Perinatal