Global Health Infectious Disease Research Program John H Adams, PhD - - PowerPoint PPT Presentation

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Global Health Infectious Disease Research Program John H Adams, PhD - - PowerPoint PPT Presentation

Aug 05, 2023 10 likes •83 views

Global Health Infectious Disease Research Program John H Adams, PhD Distinguished USF Health Research Professor 21 st Century World Class Scholar, 2007 Chair, USF Research Council USF College of Public Health Department of Global Health

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Global Health Infectious Disease Research Program

John H Adams, PhD

Distinguished USF Health Research Professor 21st Century World Class Scholar, 2007 Chair, USF Research Council USF College of Public Health Department of Global Health

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  • 2 – USF Undergraduate

Honors Students

  • 4 – Doctoral

Candidates/2 PhDs awarded

  • 1 – MSPH/MPH students
  • 5 – PhD/MD level scientists
  • 6 – Full-time Research Staff
  • 3 – Part-time

Staff/Research Assistants

2013-2014 Research Program

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Functional genomics for drug discovery

  • Funding NIH grants, MMV; $2,266,499:

R01AI094973, R21AI098098, R21AI105328

  • US Patent 7932088 (April 26, 2011 ) awarded for

piggyBac transposon use in malaria parasites

  • Goal: improve use of current drugs and develop new

types of antimalarial drug

  • Obstacle: modern genetics is difficult with malaria

parasites

  • A translational study that combines genetics,

computational biology, and medicinal chemistry

  • Key USF faculty links: Dennis Kyle, Rays Jiang, Bill Baker

High content image analysis Genetics + computational biology In silico drug discovery Flow cytometric Quantitative analysis

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Functional genomics for drug discovery

Simple pairwise comparisons Multipairwise comparisons Clusters functionally link genes & drugs data link knowns and unknowns

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Functional genomics for drug discovery

Identify targets linked to drug mode of action

How results are used to identify drug targets

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Functional genomics for drug discovery

Define chemotype of unknown drugs

How results are used to identify new drugs

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Enabling Technologies: ‘Lab-on-a-Chip’ Liver Model

Collaboration with Drs. Dennis Kyle (USF) and Wajeeh Saadi USF-Draper Laboratories. Grant support from BMGF $11,523,029/5years

  • Goal: provide in vitro

screening platform for antimalarial drug discovery research.

  • Obstacles: human liver

cells are difficult to grow & maintain in culture; requires sophisticated insectary laboratory

  • A translational study that

combines parasitology, drug discovery, and bioengineering.

Basic research of parasite biology + advanced bioengineering