For Better or Worse: Clinical Correlation of SOX9 and Irradiated - - PowerPoint PPT Presentation

▶
for better or worse clinical correlation of sox9 and
SMART_READER_LITE
LIVE PREVIEW

For Better or Worse: Clinical Correlation of SOX9 and Irradiated - - PowerPoint PPT Presentation

Jan 19, 2024 218 likes •391 views

For Better or Worse: Clinical Correlation of SOX9 and Irradiated Rectal Cancer Xiuzhen Duan, Brandon Trac, and Xianzhong Ding, Department of Pathology Loyola University Medical Center Maywood, IL 60153 USA SOX9 and Cancer Stem-like Cells

slide-1
SLIDE 1

For Better or Worse: Clinical Correlation

  • f SOX9 and Irradiated Rectal Cancer

Xiuzhen Duan, Brandon Trac, and Xianzhong Ding, Department of Pathology Loyola University Medical Center Maywood, IL 60153 USA

slide-2
SLIDE 2

SOX9 and Cancer Stem-like Cells

  • it is well accepted that cancer stem-like cells

are the main driving force behind tumor formation, metastasis, and chemoresistance

  • Cancer stem like cells exhibit diverse cell

properties including self renewal, differentiation capacity, and resistance to apoptosis and chemotherapy

slide-3
SLIDE 3

SOX9

  • Sex-determining region Y (SRY)-box 9 protein (SOX9) is

a member of the SOX family of transcription factors

  • SOX9 participates in a variety of functions, such as

tumor cell differentiation, stem-like cell lineage formation and epithelial mesenchymal transition

  • Role of SOX9 in colon cancer: controversial
  • Effect of chemoradiation on SOX9 expression unclear
slide-4
SLIDE 4
slide-5
SLIDE 5
slide-6
SLIDE 6
slide-7
SLIDE 7

Aims and Methods

  • The objectives of this study is examining SOX9

expression in pre- and post-irradiated rectal cancer

  • 25 patients with locally advanced rectal cancer

– Moderately differentiated adenocarcinoma – Received neoadjuvant chemoradiation therapy followed by surgery

slide-8
SLIDE 8

Aims and Methods

  • SOX9 expression

– Evaluated by IHC – 4-tier grading system

  • 0: no expression
  • 1: low expression
  • 2: moderate expression
  • 3: high expression

– Percentage of SOX9 positive cells

slide-9
SLIDE 9
slide-10
SLIDE 10
slide-11
SLIDE 11
slide-12
SLIDE 12

Pre-CRT post-CRT Pre-CRT post-CRT Non-tumor mucosa Adenocarcinoma

slide-13
SLIDE 13

Pre-CRT post-CRT Pre-CRT post-CRT Non-tumor mucosa Adenocarcinoma

slide-14
SLIDE 14

SOX9 expression and tumor response to neoadjuvant therapy

  • 2 cases with complete response to

neoadjuvant therapy

– High expression of SOX9

  • No correlation of tumor volume reduction and

SOX9 expression prior to chemotherapy

  • No association with lymph node metastasis

and late distant metastasis

slide-15
SLIDE 15

Conclusions

  • Role of SOX9 in colon cancer is still

controversial

  • Might be a potential marker to predict tumor

response to chemoradiation and oncological

  • utcomes
  • Large cohort studies are needed to be

conclusive