Executing Global Partnership (GP) projects in Sub-Saharan Africa and - PowerPoint PPT Presentation

Executing Global Partnership (GP) projects in Sub-Saharan Africa and Egypt Martin H. Groschup Head of Institute of Novel and Emerging Infectious Diseases at Friedrich-Loeffler-Institut Island of Riems, Germany Institute of Novel and Emerging Infectious Diseases 2nd OIE Global Conference on Biological Threat Reduction, Ottawa, Oct. 31 st – Nov. 2 nd ,.2017

Prevalence and diagnostics of Ø Crimean-Congo hemorrhagic fever, Egypt Ø Rift valley fever and Mauri- tania Ø zoonotic paramyxoviruses in Sierra Came- Leone roon Mauritania Sierra Leone Cameroon Egypt Centre Njala National Kafr el Sheik National de University, Veterinary University l'Élevage Department Laboratory et de of Animal (LANAVET) Mansoura Recherches Science University Vétérinaires University (CNERV) Yaounde I Institute of Novel and Emerging Infectious Diseases Kick off 2013

• Two 3-year program terms (2013-2016 and 2017-2019) are part of Germany's commitment to the G7 Global Partnership. • The program is based on the Biological Security Deliverables of the G7 Biosecurity Sub-Working Group (BSWG). • The program is funded and managed by the Federal Foreign Office. • Program Goals – Reduce global biological security risks – Reinforce Germany’s contribution to global biosecurity – Strengthen Germany’s role in the Global Partnership group Institute of Novel and Emerging Infectious Diseases 3

Phase I (2013-2016, blue and red) Phase II (2017-2019, red) Institute of Novel and Emerging Infectious Diseases + regional: GIBACHT Academy

Implementing Partners Bundeswehr Institute of Microbiology Institute of Novel and Emerging Infectious Diseases

Toolbox approach The activities supported by the program are divided into six key areas with a large number of different modules. This methodological framework ensures a comprehensive contribution to global biosafety and allows tailor-made projects for each partner country. Institute of Novel and Emerging Infectious Diseases 6

Implementing the six key areas Biosafety and Biosecurity: Ensure safe and adequate working conditions in order to prevent accidents (biosafety). Establish security standards in laboratories to prevent theft / intentional misuse of dangerous agents (biosecurity). Implementation of biosafety/biosecurity in national legislations Capacity Building: Building the laboratory and personnel capacities to improve public health systems Surveillance: On-going systematic collection, analysis, evaluation and dissemination of data on infectious diseases for the purpose of planning, implementation and evaluation of disease control measures. Detection and Diagnostics: Develop / establish pathogen detection and diagnostic assays in laboratories. Networking: Establishment national, international and intersectoral cooperation. Information about biological threats is actively shared with global public health community. Awareness Raising: For biosafety / biosecurity issues (incl. challenges to the health system) to design and implement risk mitigation strategies. Institute of Novel and Emerging Infectious Diseases 7

Interactions with top-level political authorities v Meetings v Networking v Implementation of biosecurity agenda Dr. Lemrabott Dr. Winter CVO Mauritania German Ambassador Mai Moussa Abari, Dr. Taiga, Minister of Livestock, Fisheries Institute of Novel and Emerging Infectious Diseases FAO Representative and Animal-Industries, Cameroon to Cameroon

Training of African experts at FLI in 2013-2017 24 participants from Ø Sierra Leone (6) Ø Cameroon (7) Ø DR Congo (4) Ø Mauritania (1) Ø Egypt (6) Training (2-3 weeks) included ELISA, IFA and PCR for CCHFV and RVFV, aspects of biosafety and biosecurity Training success was evaluated by blinded internal ring trials with participants Fifa World Cup 2014 Institute of Novel and Emerging Infectious Diseases

Nine workshops in African partner laboratories 2013-2017 10-days Workshop 10-days Workshop 14-days Workshop 10-days Workshop Outbreak-Management, Diagnostic, Biosafety, Diagnostic, Organization of Diagnostic, Biosafety, Diagnostics, Biosafety Organization of Laboratory Laboratory + Infrastructure Organization Infrastructure Training of 4 scientists/ Training of 5 scientists/ Training of 12 scientists/ Training of 12 scientists/ lab technicians / students lab technicians / students lab technicians / students lab technicians / students Mauritania, 2013 Sierra Leone, 2014 DR Congo, 2014 Cameroon, 2015 Mauritania, 2013 Institute of Novel and Emerging Infectious Diseases

Institute of Novel and Emerging Infectious Diseases

Key question: How to keep the v infrastructures functional and v personnel motivated and trained over time? à Goal is to achieve long- term sustainability Institute of Novel and Emerging Infectious Diseases

Motivations: 1) Donor country 2) Donor country partnering institution 3) African partner countries 4) African partnering institutions Institute of Novel and Emerging Infectious Diseases

Motivations: 1) Donor country Ø Striving for the Biological Security Deliverables 2) Donor country partnering institution 3) African partner countries Ø Striving for the Biological Security Deliverables Ø Capacity building - legal framework for biosecurity - functional laboratories - training of diagnosticians / scientists 4) African partnering institutions Institute of Novel and Emerging Infectious Diseases

Motivations: 1) Donor country Ø Striving for the Biological Security Deliverables 2) Donor country partnering institution 3) African partner countries Ø Striving for the Biological Security Deliverables Ø Capacity building - public health system - livestock industry - biodiversity / tourism 4) African partnering institutions Institute of Novel and Emerging Infectious Diseases

Motivations: 1) Donor country 2) Donor country partnering institution 3) African partner countries 4) African partnering institutions Ø Infrastructure and workforce development Ø Network building Research interests Ø Institute of Novel and Emerging Infectious Diseases

Motivations: 1) Donor country 2) Donor country partnering institution Ø International animal health mission Ø Research interests 3) African partner countries 4) African partnering institutions Ø Infrastructure and workforce development Ø Network building Research interests Ø Institute of Novel and Emerging Infectious Diseases

Common research interests of FLI and African partners Preparedness for the emergence of novel or already known biothreat pathogens • Virus discovery and phylogeny studies • Virus isolation • Diagnostic method development (qPCR, serology) and assay validation • Surveillance and molecular epidemiology • In vivo pathogenesis studies under BSL3/4 conditions • Development of veterinary and public health protection strategies (management, vaccination) à Access to biological samples Publications together with African partners Institute of Novel and Emerging Infectious Diseases

Major scientific achievements Development of a battery of new molecular and serological assays for • the diagnosis of RVFV and CCHFV infections Better understanding of prevalence of RVFV and CCHFV infections in • animals for many African countries Detection of target pathogens in risk areas • Detection of off-target hemorrhagic fever viruses (e.g. NgariV) • Insight into the role of ruminants (cattle, goats, sheep, camels etc.) • as reservoir hosts and of arthropods as vectors for these bunyaviral hemorrhagic fever viruses (studies ongoing) Institute of Novel and Emerging Infectious Diseases