SLIDE 1 Paper Data analysis Queries & Tables EuResist centers EuResist Board Idea
From any EuResist member or non-member Is the proposal sound and ethical? Are my data available for this study? Sent from the EuResist IT staff to the proposal P.I. Done by the proposal P.I. and statisticians P.I. and statisticians, authorship according to EuResist rules
SLIDE 2 Paper Data analysis Queries & Tables EuResist centers EuResist Board Idea
From any EuResist member or non-member Is the proposal sound and ethical? Are my data available for this study? Sent from the EuResist IT staff to the proposal P.I. Done by the proposal P.I. and statisticians P.I. and statisticians, authorship according to EuResist rules
Contribution of each individual step to the overall effort and time required
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Biomedical domain IT & data management domain
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Learn the basics of data
structure
Avoid professional lingo Learn the basics of the
biomedical topic
Avoid professional lingo
Biomedical domain IT & data management domain
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Create and nurture a generation of "middleware" professionals Increase accuracy of data collection Minimize misunderstandings in generating datasets Expedite the process from data to product
Biomedical domain IT & data management domain
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Integration between the biomed and IT domains Cooperation & networking Periodical event Mostly hands-on format Working group with biomedical and IT tutor Queries are followed up remotely after the on-
site course
Suggestions for improvement always welcome!
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09:00 – 09:30 Introduction and Signing NDAs Let’s work! (Group A: floor -1; Group B: ground floor) 09:30 – 13:00 Query 1: Does resistance to NRTIs
influence response to INSTI plus NRTIs?
13:00 – 14:00 Lunch 14:00 – 17:30 Query 2: Efficacy of dual regimens as
switch in patients with undetectable VL, including the influence of past resistance
17:30 – 18:30 Presentation of the work done (plenary)
SLIDE 9 2002 – Collection of clinical data started to complement virological data 2004 – ARCA web site and db launched 2005 – ARCA
proposals 2014 – Major system revision to include Hepatitis data and turn to complete Electronic Medical Recording system
SLIDE 10 Building treatment response models and treatment decision
tools
On-line Electronic Medical Recording system HIV, HBV, HCV genotype interpretation via the AntiViroScan
algorithm, curated by the University of Siena
Repository for HIV, HBV, HCV research proposals requiring a
large amount of data or a specific uncommon patient population
Middle layer between local clinics and national/international
public programs, particularly focusing on response to antiviral therapy or molecular epidemiology
www.dbarca.net → Obiettivi
SLIDE 11 www.dbarca.net → Interroga il db in tempo reale
SLIDE 12 P.I. plus up to 4 collaborators Up to 15 total authors adding the ARCA Authorship
Delegates (subject to editorial policy limits)
(web site -> Statuto e regolamenti)
Individual DB’s Study dataset Included in authorship Not included in authorship but credits saved for future studies www.dbarca.net → Statuto e regolamenti
SLIDE 13 Publication system launched in 2005 (HIV) 110 data requests including 18 from abroad
107 publications
- 78 Conference papers
- 36 Papers
- Low paper/conference ratio (0.5)
Publications (public area) and requests (private area)
tracking available on the web site
(web site -> Pubblicazioni; web site -> Richieste)
www.dbarca.net → Pubblicazioni
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Use of real life data instead of
performing prospective clinical studies
Introduction to the data base structure Introduction to structured query language Workshop queries: Query 1: Does resistance to NRTIs influence
response to INSTI plus NRTIs?
Query 2: Efficacy of dual regimens as switch in
patients with undetectable VL, including the influence of past resistance
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Follow-up All participants will be contacted to proceed
with the analysis with the aim to reach a publication with all active participants
Who is interested to work on the db? Who would like to participate in this
workshop next year (2 groups: advanced and basic…..)
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Cooperation of partners (idea by ARCA) Each partner remains owner of his data Submit data to an integrated database Use data from the EuResist database Agree that others use your data upon request
(case by case decision)
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