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EPISTEM European Project to guide and investigate the potential for - - PowerPoint PPT Presentation
EPISTEM European Project to guide and investigate the potential for - - PowerPoint PPT Presentation
EPISTEM European Project to guide and investigate the potential for HIV cure by Stem Cell Transplantation. www.epistem-project.org EPISTEM Project to guide and investigate the potential for HIV cure in HIV-infected patients requiring
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Scientific Investigators: Javier Martinez-Picado (PI) and Annemarie Wensing (PI), Monique Nijhuis, Gero Hütter, Jan van Lunzen, Vanderson Rocha Clinical Investigators: Jürgen Kuball, Jose Luis Diez Martin
Investigators
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What does EPISTEM provide?
Panel Experts in Hematology Infectious Diseases Virology Immunology Pharmacology
Clinical, Pharmacological and Ethical Guidance
by multidisciplinary video calls, by provision of protocols
Donor search and CCR5 host testing Detailed Sampling Protocol Ultra-sensitive virological and immunological assays
qpcr, digital droplet pcr, single copy, viral
- utgrow, in depht phenotypic and genotypic
tropism characterisation, B/T cell assays, innate immunity, subset analyses and others
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To prospectively study allogeneic SCT recipients with HIV-1 infection, collecting complete information on underlying malignancy, chemotherapy, transplant procedure, donor selection, HIV-tropism, cART, and samples to be stored before and after the transplant.
AIM
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To systematically study recipient samples for (i) multiple complementary quantifications of the viral reservoirs, (ii) molecular and functional characterization of infecting virus, and (iii) immunological determinations during the multiple phases of an allogeneic SCT, which might help to understand the biological bases of a potential new case of HIV-1 cure.
AIM
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Organisation
Currently 11 patients included
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- Mrs. Antoinet van Kessel/ Drs. Karin Siebelt
A.vankessel-4@umcutrecht.nl or K.G.Siebelt@umcutrecht.nl +31 88 7556526
www.epistem-project.org
If you have an HIV infected patient who need a SCT please Contact
The EPISTEM project is supported by AmfAR Research Consortium on HIV eradication (ARCHE) Research Grant # 108930-56-RGRL