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Enabling Data-Driven Healthcare with Pervasive Technology - - PowerPoint PPT Presentation

Enabling Data-Driven Healthcare with Pervasive Technology Temiloluwa Prioleau Assistant Professor of Computer Science Dartmouth College Webinar on Diabetes and Technology Management Center for Digital Health Interventions March 17, 2020


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Enabling Data-Driven Healthcare with Pervasive Technology

Temiloluwa Prioleau Assistant Professor of Computer Science Dartmouth College Webinar on Diabetes and Technology Management Center for Digital Health Interventions March 17, 2020

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Background

Pervasive technologies provide unparalleled opportunities for:

  • 1. Continuous sensing of people in daily living
  • 2. Real-time detection of health abnormalities
  • 3. Data-informed decision and treatment strategies
  • T. Prioleau - Department of Computer Science

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Location Blood Glucose Rehabilitation Heart Rhythm Activity

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Diabetes & Technology

Diabetes

  • Prevalent chronic condition
  • Characterized by impaired

glucose metabolism

State-of-art technology

  • Continuous glucose monitor
  • Insulin pump
  • T. Prioleau - Department of Computer Science

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https://jdrf.org.uk/information-support/treatments- technologies/continuous-glucose-monitors/

High blood glucose Low blood glucose

https://jdrf.org.uk/news/diabetes-tech-whats-on-its-way/

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Project: Digital SMD

Developing Digital Tools for Improved Self-Management of Diabetes

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  • T. Prioleau – Department of Computer Science

User Studies

  • Understand clinical and

patient needs

  • Evaluate technology solutions

Pervasive Sensing

  • Leverage mobile and wearable

technology for continuous sensing

Data Analytics

  • Investigate behavioral factors

that affect management

  • Develop algorithmic solutions

to inform treatment

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Digital SMD

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Reflection Needs for Personal Health Data

User Studies

Adherence to CGM Use

Data Mining

  • T. Prioleau – Department of Computer Science

This Talk Algorithms for Blood Glucose Prediction Sensing More than Physiology

Machine Learning

Behavioral Factors and Glucose Trends

Data Mining

Other Work

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Digital SMD

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Reflection Needs for Personal Health Data

User Studies

Adherence to CGM Use

Data Mining

  • T. Prioleau – Department of Computer Science
  • T. Prioleau, A. Sabharwal, M. Vasudevan, “Understanding Reflection Needs for Personal Health

Data in Diabetes”, Int. Conf. on Pervasive Computing Technologies for Healthcare, May 2020. (forthcoming)

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Reflection on Personal Health Data

Continuous Glucose Monitor (CGM)

  • Enable real-time monitoring of glycemic trends to inform immediate corrective action
  • Enable retrospective analysis of glucose trends to inform future management <- Significantly underutilized

Limitation

  • A lack of effective methods for data reporting and interpretation
  • For example, physicians tend to review primarily the most recent [two-weeks] data to assess management during clinical visits
  • Potentially missing insights in long-term data that is currently not reviewed/analyzed

7

  • T. Prioleau – Department of Computer Science

Fig: Conventional visual is daily overlay plot [https://www.dexcom.com/clarity]

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Two-Phase User Study

Participants:

  • 20 subjects (10 patients with diabetes, 7 clinicians, 3 care-givers)
  • 5 subjects in Phase 1 user study
  • 15 subjects in Phase 2 user study
  • T. Prioleau - Department of Computer Science

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Needs Assessment (Survey) Develop Visualization (PixelGrid_v1) Concept Validation (Phase 1) Improve Visualization (PixelGrid_v2) User Study (Phase 2)

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Needs Assessment Survey

Example Question:

1. What do you wish CGM reports included that could help and/or speed up analysis and interpretation of diabetes management?

Top responses:

  • 1. Automatically extract trends/patterns, detect changes in management

and suggest specific behavior changes

  • 2. Integrate data from insulin pumps, bluetooth insulin pens, and

carbohydrate intake

  • 3. Enable reviewing and analysis of multiple days of day
  • T. Prioleau - Department of Computer Science

9

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DataViz + Concept Validation

  • T. Prioleau - Department of Computer Science

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1-Week CGM Assessment

Low Wear Time (< 50%) Very High BG (> 250 mg/dL) High BG (180 - 250 mg/dL) In Range BG (70 - 180 mg/dL) Low BG (54 - 70 mg/dL) Very Low BG (< 54 mg/dL)

PixelGrid: m x n matrix-based plot

  • Designed to facilitate comparison by date, time of day, and day of week
  • Recurrent time block chosen to identify underlying temporal patterns

Sun Multi-Week Summary q Poor TIR = 26% q Moderate TIR = 50% q Good TIR = 24%

Insufficient Data Poor TIR (< 50%) Moderate TIR (50 - 70%) Good TIR (> 70%)

* TIR means Time-in-Range

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User Study – Q&A

Example Question:

  • 1. What do you like or NOT like about the PixelGrid?

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Outcome: Feedback will be used to inform future work on insight- suggestive visualization of long-term diabetes data.

S18 (physician)

I do like how I can visualize

  • verall patterns in ONE

screenshot.

S12 (patient)

If there is no detectable patterns, you [the end- user] will just see random colors which can be frustrating to a patient.

Example responses:

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Follow-up Work

  • 1. Automated algorithm to identify patterns of adverse glycemic

events and support personalized goal setting

  • 2. Integrate data from other mobile devices (e.g. insulin pumps

& smartphones) to contextualize adverse glycemic events

  • T. Prioleau - Department of Computer Science

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Digital SMD - Ongoing Work

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Reflection Needs for Personal Health Data

User Studies

Adherence to CGM Use

Data Mining

  • T. Prioleau – Department of Computer Science

10/10/19

  • S. Vhaduri, T. Prioleau, “Adherence to Personal Health Devices: A Case Study in Diabetes

Management,” Int. Conf. on Pervasive Computing Technologies for Healthcare, May 2020. (forthcoming)

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Adherence to CGM Devices

  • T. Prioleau - Department of Computer Science

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Background

  • CGM use = greatest prediction for lowering

hemoglobin A1C [American Diabetes Association] Problem

  • Adherence to CGM use is a challenge for

some patients with diabetes

CGM Use

https://hcp.eversensediabetes.com/why-eversense-cgm

Research Objective

  • Investigate whether and to what extent achieving target glycemic goals

affect wearing behavior of CGMs in diabetes management

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Approach

Data-driven analysis of patient data (n=44)

  • 1. Statistical tests to study the significance of data gaps in BG categories
  • 2. Evaluated the duration of data gaps in normal vs. abnormal BG

categories

  • T. Prioleau - Department of Computer Science

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Understanding Data Gaps

Data gap is a period of contiguous missing data in CGM recording Assumption for analysis:

  • Data gaps are associated with non-wearing given that a physiological signal (e.g.

blood glucose) always exists when wearing device is worn.

  • However, other reasons for data gaps include sensor malfunction/battery life
  • T. Prioleau - Department of Computer Science

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Fig: conventional daily overlay plot showing 1-week data

Data Gap Characterization:

  • 1. Increase in BG (e.g. C)
  • 2. Decrease in BG (e.g. A)
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Some Results

1. Subjects with poorly controlled diabetes (A1C > 7) had on average longer data gaps (i.e. worse adherence to CGMs) than subjects with well- controlled diabetes (A1C < 7) 2. Longer duration of data gaps occurred in suboptimal BG categories and the longest data gaps occurred in the most severe categories (i.e. very low, very high)

  • T. Prioleau - Department of Computer Science

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Key Takeaway

Implement data-driven adherence analysis in embedded algorithms to better understand context associated with CGM nonadherence

  • T. Prioleau - Department of Computer Science

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Increased CGM Use Improved Glycemic Outcomes

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Digital SMD

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  • T. Prioleau – Department of Computer Science

Algorithms for Blood Glucose Prediction Sensing More than Physiology Machine Learning Behavioral Factors and Glucose Trends Data Mining

Other Work

Reflection Needs for Personal Health Data

User Studies

Adherence to CGM Use

Data Mining

This Talk

  • S. Morton, R. Li, S. Dibbo, T. Prioleau, “Data-driven Insights on Behavioral Factors that Affect

Diabetes Management”, Under Review, 2020.

  • K. Gu, R. Dang, T. Prioleau, "Neural Physiological Encoder: A Simple Module for Blood Glucose

Prediction," Under Review, 2020.

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Thank You! Questions?

Contact: Temiloluwa Prioleau; E. tprioleau@dartmouth.edu; W: www.t-prioleau.com 20

Endocrine Team - Dartmouth Hitchcock Medical Center (DHMC) Research Assistants Support

https://www.tidepool.org/