Ebola and the Eye Allen Eghrari, MD Wilmer Eye Institute at Johns - - PowerPoint PPT Presentation

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Ebola and the Eye Allen Eghrari, MD Wilmer Eye Institute at Johns - - PowerPoint PPT Presentation

Jan 10, 2024 138 likes •471 views

Ebola and the Eye Allen Eghrari, MD Wilmer Eye Institute at Johns Hopkins Ophthalmic Anesthesia Society Annual Meeting CDC/Cynthia Goldsmith A high case fatality rate <21 years old: 57% >45 years old: 94% 28,555 affected 11,311

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Ebola and the Eye

Allen Eghrari, MD Wilmer Eye Institute at Johns Hopkins Ophthalmic Anesthesia Society Annual Meeting

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CDC/Cynthia Goldsmith

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A high case fatality rate

  • <21 years old: 57%
  • >45 years old: 94%
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28,555 affected 11,311 deaths

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Credit: Liam Sharp

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Early reports of survivor complaints

Survivors Conference in Kenema, late 2014

http://www.who.int/features/2014/post-ebola-syndrome/en/

An urgent need for knowledge and intervention

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Eye sub-study objectives

  • Explore causes of decreased vision and other
  • cular problems reported by EVD survivors
  • Relate the timing of ocular complaints to disease

course and other systemic problems

  • Classify the ocular pathology present in EVD

survivors, and define the nature of associated

  • cular inflammation
  • Facilitate treatment for EVD-associated vision loss
  • Follow patients longitudinally for up to 5 years
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Our clinic

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Training

  • Practice with equipment
  • Didactics on eye topics
  • Monitoring and real-time

feedback

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Training

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Training

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Posterior synechiae

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Inflammatory anterior subcapsular plaque Posterior subcapsular cataract

Lens

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2+ AC cell, 1+ vit cell, 1+ haze ERM, minimal CME, no vitreous cell

Vitreous cells Clear vitreous with early PVD

Vitreous Cell

OD OS

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Focal retinal lesions

Disruption of outer retina Focal lesion

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Intraretinal fluid

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Research in Liberia

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History of Ophthalmology Clinical Research in Liberia

  • Infectious Diseases
  • Onchocerciasis
  • Cataract surgery in leprosy
  • Case reports of Liberians abroad
  • West African Crystalline Maculopathy
  • Tuberculosis conjunctivitis

Am J Trop Med Hyg. 1963 Sep;12:761-6

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Prevail 7 Clinical Trial

  • Is it safe to do surgery in eyes of Ebola survivors?
  • Can the virus persist in the central nervous system?
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Surgery, Anesthesia, and Ebola

  • Risks to anesthesiologist
  • Risks to patient
  • Risks to surgeon
  • Risks to staff
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