SCIENTIFIC AND HUMANITARIAN E X P E D I T I O N IN THE HIGHEST CITY OF THE WORLD FEBRUARY 2019 www.expedition5300.com
A N EXPEDITION IN THE HIGHEST CITY OF THE WORLD LED BY A WORLD-CLASS LABORATORY FROM GRENOBLE ALPS UNIVERSITY WWW.HP2.UNIV-GRENOBLE-ALPES.FR WWW.EXPEDITION5300.COM 0 2 |30
THE ESSENTIALS T E A M O F R E N O W N E D R E S E A R C H E R S O N A LT I T U D E , H Y P O X I A A N D G E N E T I C S W H O I S L E A D I N G A S C I E N T I F I C A N D H U M A N I TA R I A N E X P E D I T I O N U N I Q U E A N D O U T S T A N D I N G IN THE HIGHEST CITY OF THE WORLD H Y P O X I A , W H AT I S I T ? “ Decrease in the amount of oxygen available in the blood or tissues. This situation is associated with a rise in altitude or certain pathologies (respiratory for example). At the cerebral level, hypoxia results in a decrease in cognitive performance, memory issues, slowness of ideation and, in extreme cases, loss of consciousness. Hypoxia is associated with a series of cardio-respiratory and biological responses that may be protective or “ deleterious. 0 3 |30
THE ESSENTIALS L e d b y H P 2 L a b o r a t o r y, t h e U n d e r s t a n d m e c h a n i s m e s o f La Rinconada, in Peru is the highest international leader in altitude and altitude adaptations to treat city in the world (5300m) where more hypoxia research that will collaborante p a t i e n t s w i t h r e s p i r a t o i r e than 50 000 inhabitants are living with other laboratories. In total, more p a t h o l o g i e s a t s e a l e v e l . permanently. than 15 scientific and medical experts Supports (material, knowledge,…) to directly involved in this project. the local population. To develop new treatments of Scientific and humanitarian expédition Setting a laboratory of physiology and diseases related to lack of oxygen over a period of 6 weeks beginning of human biology in the heart of La and advance research in other 2019. Rinconada. areas : technology, space, ... 0 4 |30
THE ESSENTIALS Participate in an exceptional scientific Associate your profile to an expedition Contribute to developing our with a strong scientific, innovative and and human adventure. EXPEDITION knowledge on the limits of human human dimension with the best 5300 is the first expedition in the world adaptation to the extreme environment specialists in the world. to study permanent habitation at such of high altitude. an altitude. Expected benefits both for highlanders Spin-off in Space Exploration : future To explore new treatment stratégies for and for lowlanders travelling or working lunar and Mars missions will take place chronic diseases, in particular at high altitude. in space modules where oxygen respiratory patients suffering from a concentration will correspond to similar decreased oxygen level because of altitudes. their pathology. 0 5 |30
LINE OF ACTION 02 01 03 04 Contacts Appendices PRESENTATION LET’S SHARE Project Adventure
1 PROJECT PRESENTATION
OUR RESEARCH Studying the mechanisms that allow In 15 years, the Hypoxia Physiopathology (HP2) laboratory of INSERM and Grenoble highlanders to live with a very limited quantity Alpes University has become the French of oxygen but also their intolerance to this altitude hypoxia, is critical to identify and leader and one of the most recognized understand the extreme limits of the international groups in the field of hypoxia research . adaptation capacities of the guman body to its environment. The work of this team has led to many high- level scientific publications and have a strong Humanity has distinguished itself through millennia by its formidable abilities of societal impact, in particularly a significant adaptation to its living environment and its impact in the field of altitude and for people traveling or residing there for an extended evolutions. Adaptation to the environment is period or permanently. one of the outstanding aspects and a decisive contribution to the development of habitation throughout the planet Earth. 0 8 |30
LA RINCONADA : A UNIQUE PLACE This is the highest city in the world, nestled in Peru with nearly UNDERSTAND THE MECHANISMS THAT ALLOW THE HUMAN BODY TO ADAPT TO FUTURE ENVIRONMENTAL CHANGES. 50,000 inhabitants living at over 5000 m altitude. While it is generally considered that permanent human life is not possible beyond 5000 m, the population of La Rinconada is challenging current knowledge on the adaptations of the human organism to its environment and in particulary to hypoxia. TO SUPPORT SPACE RESEARCH BY REPRODUCING ALTITUDE CONDITIONS SIMILAR TO LIFE ON MARS. La Rinconada inhabitants are born, grow and work at an altitude higher than Mont Blanc that climbers hardly reach due to the lack of oxygen. TO DEVELOP OTHER AREAS OF RESEARCH THANKS TO OUR RESULTS : TECHNOLOGICAL AND MEDICAL ... A significant part of the local population shows difficulty in tolerating the lack of oxygen and develops symptoms which we know only superficially and whose treatment strategies have still to be L A R I N C O N A D A ? determined. Analyze, understand, act, these are the main objectives of A T R U E O P P O R T U N I T Y T O D E V E L O P O U R KNOWLEDGE AND ADDRESS FUTURE SCIENTIFIC , EXPEDITION 5300 to enable Research and Medicine to move MEDICAL AND SOCIAL CHALLENGES . forward. 0 9 |30
LA RINCONADA : A UNIQUE PLACE
AN EXPEDITION THAT LINKS SCIENCE WITH HUMANITY IMPLEMENTATION OF COLLABORATIONS AND PARTNERSHIPS BETWEEN PERUVIAN AND FRENCH The development of scientific knowledge on the human SCHOOLS adaptations and maladaptations to extreme environments, and in particular high altitude hypoxia, is a central element of SCIENTIFIC AND MEDICAL TRAINING this project. Much larger issues can be addressed as the entire project unfolds. In La Rinconada where the population is remote, there are SCIENTIFIC AND MEDICAL EQUIPMENT FOR LOCAL STAFF difficult living conditions due to the environment (isolation, lack of oxygen, extreme temperatures, etc.), pollution (due to the concentration of population, industry lack of modern CREATION OF PREVENTION MATERIALS ON THE infrastructure) and relative poverty. Our project aims to E F F E C T S O F H I G H A LT I T U D E F O R L O C A L make this city better known to the public and POPULATION international institutions, to initiate medical, health and educational projects benefiting to local population. EXTENSION AND AWARENESS VIA CONFERENCES O N T H E S P E C I F I C I T I E S O F H Y P O X I A , T H E ENVIRONMENT,… Learn more ? For more information on our research, please refer to the note we sent you as an attachment. 1 1 |30
AN EXPEDITION LED BY THE BEST RESEARCHERS DR. SAADI KHOCHBIN DR. SAMUEL VERGÉS PHYSIOLOGIST, EXPERT IN HYPOXIA - RESEARCH DIRECTOR, EXPERT IN AND EXPEDITION LEADER GENETICS AND EPIGENETIC PR. PHILIPPE CONNES PHYSIOLOGIST, DR. STÉPHANE DOUTRELEAU HAEMATHOLOGIST EXPERT DR. JULIEN THÉVENON CARDIOLOGIST SPECIALIZED IN EXERCISE SCIENCES MEDICL CONSULTANT, EXPERT IN GENETICS PR. FRANÇOIS ESTÈVE DOCTOR AND PHYSICIAN DR. SÉBASTIEN BAILLIEUL DR. AURELIEN PICHON DOCTOR IN SPORT MEDICINE AND DR. PAUL ROBACH REHABILITATION PHYSIOLOGIST, SPECIALIST IN PHYSIOLOGIST AND RESPIRATORY CONDITIONS IN PROFESSIONAL MOUNTAIN GUIDE HYPOXIA DR. IVAN HANCCO PERUVIAN DOCTOR, PHD STUDENT 1 2 |30 OF HP2 LABORATORY
C O M M U N I C AT I O N T E A M AXEL PITTET LOUIS LAFORET VIDEO MAKER MARKETER, COMMUNICATION PHOTOGRAPHY SPECIALIST T E C H N I C A L P A R T N E R S CHAIR «MOUNTAIN, ALTITUDE, HEALTH » OF UNIVERSITY GRENOBLE ALPES FOUNDATION THIS CHAIR WAS LAUNCHED IN 2018 AND SUPPORTS THE RESEARCH IN THE FIELD OF MOUNTAIN AND ALTITUDE HEALTH. IT ESPECIALLY SUPPORTS THE PROJECT EXPEDITION5300. THIS SUPPORT IS IN CONJUNCTION WITH THE SCIENTIFIC AND MEDICAL STAFF OF UNIVERSITY GRENOBLE ALPS TOGETHER WITH PRIVATE CONTRIBUTORS AND PARTNERS ASSOCIATED WITH THIS PROJECT. CENTER OF ALTITUDE EXPERTISE (EXALT) THIS CENTER OF EXPERTISE JOINS THE MAIN EXPERTS AND CENTRAL INSTITUTIONS OF FRANCE AND ALPINE COUNTRIES IN THE FIELD OF MOUNTAIN AND ALTITUDE HEALTH. EXALT IS A COLLABORATIVE NETWORK INITIATING AND SUPPORTING RESEARCH PROJECTS AND INNOVATION IN RELATION TO ALTITUDE. THE EXPEDITION5300 PROJECT IS SUPPORTED BY EXALT. 1 3 |30
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