DRUG DISCOVERY: A NEW ANTIBIOTIC TO TREAT KOALAS WITH CHLAMYDIA - - PowerPoint PPT Presentation

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Jul 04, 2023 122 likes •276 views

DRUG DISCOVERY: A NEW ANTIBIOTIC TO TREAT KOALAS WITH CHLAMYDIA INFECTIONS Dr Wilhelmina Huston Wilhelmina.huston@uts.edu.au @willaonthego ACKNOWLEDGEMENTS Lab team: Sarina Gloeckl Amba Lawrence Pooja Patel Collaborators: Adam

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DRUG DISCOVERY: A NEW ANTIBIOTIC TO TREAT KOALAS WITH CHLAMYDIA INFECTIONS

Dr Wilhelmina Huston Wilhelmina.huston@uts.edu.au @willaonthego

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ACKNOWLEDGEMENTS

Lab team: Sarina Gloeckl Amba Lawrence Pooja Patel Collaborators: Adam Polkinghorne (USC), Amber Gillet (Aus Zoo/ Wildlife Warriers), Peter Timms (USC), Joel Tyndall (Otago), Matt Bogyo (Stanford) Funding: Queensland Government DHEP Koala Research Grant KRG016

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C. trachomatis
C. suis
C. muridarum
C. caviae
C. psittaci
C. felis
C. abortus
C. pneumoniae
C. pecorum

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RB EB 2hr PI 8hr PI 8-18hr PI 18-48hr PI (asynchronous) 48-72hr PI Persistent infection AB

http://www.healthofchildr en.com/images/gech_00 01_ 0004_0_img0276.jpg http://brighamrad.harvard.edu/Cases/bwh/images/56 R18HSG2.GIF

CHLAMYDIA TAKE OVER CELLS

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Koalas get Chlamydia too!

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WE NEED A NEW TREATMENT FOR CHLAMYDIA

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Joanna E Griffith, Thesis, USyd

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KOALA DRUGS ARE TRICKY!

Gut microbiome essential Extreme hepatic metabolism Delivery and Efficacy tricky

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Nat Museum of Aus

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KOALA CHLAMYDIA ISOLATES

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Validated against 10 clinical isolates

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Natalia – uterus cells – day 1 Natalia – uterus cells – day 5 Natalia – uterus cells – day 7 Natalia – uterus cells – day 11

Not toxic against Koala cells Works on Koala Chlamydia isolates grown in Koala cells

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JO146 OR DERIVATIVES AS A KOALA THERAPY???

Yes 3-5 year plan or faster

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OVERALL PORTFOLIO

Intracellular pathogen cultures Antibiotic susceptibility testing Primary tissue work Immune responses Diagnostics Womens health; infertility and pelvic inflammatory disease http://www.uts.edu.au/staff/wilhelmina.huston

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Summary : Drug development for the Koala Chlamydial diseases

A national icon under major threat An urgent priority A challenging scenario for drug discovery Wilhelmina.Huston@uts.edu.au

Core capabilities for research: Chlamydia culture Biochemistry Toxicity Primary Koala tissue work