DRUG DISCOVERY: A NEW ANTIBIOTIC TO TREAT KOALAS WITH CHLAMYDIA - PowerPoint PPT Presentation

Jul 04, 2023 •122 likes •273 views

DRUG DISCOVERY: A NEW ANTIBIOTIC TO TREAT KOALAS WITH CHLAMYDIA INFECTIONS Dr Wilhelmina Huston Wilhelmina.huston@uts.edu.au @willaonthego ACKNOWLEDGEMENTS Lab team: Sarina Gloeckl Amba Lawrence Pooja Patel Collaborators: Adam

DRUG DISCOVERY: A NEW ANTIBIOTIC TO TREAT KOALAS WITH CHLAMYDIA INFECTIONS Dr Wilhelmina Huston Wilhelmina.huston@uts.edu.au @willaonthego
ACKNOWLEDGEMENTS Lab team: Sarina Gloeckl Amba Lawrence Pooja Patel Collaborators: Adam Polkinghorne (USC), Amber Gillet (Aus Zoo/ Wildlife Warriers), Peter Timms (USC), Joel Tyndall (Otago), Matt Bogyo (Stanford) Funding: Queensland Government DHEP Koala Research Grant KRG016
C. trachomatis C. suis C. muridarum C. psittaci C. abortus C. caviae C. pneumoniae C. felis C. pecorum
CHLAMYDIA TAKE OVER CELLS EB 2hr PI 8hr PI RB 48-72hr PI 8-18hr PI 18-48hr PI (asynchronous) http://www.healthofchildr en.com/images/gech_00 01_ 0004_0_img0276.jpg AB Persistent infection http://brighamrad.harvard.edu/Cases/bwh/images/56 R18HSG2.GIF
Koalas get Chlamydia too! science.uts.edu.au
WE NEED A NEW TREATMENT FOR CHLAMYDIA Joanna E Griffith, Thesis, USyd science.uts.edu.au
KOALA DRUGS ARE TRICKY! Gut microbiome essential Extreme hepatic metabolism Delivery and Efficacy tricky Nat Museum of Aus science.uts.edu.au
KOALA CHLAMYDIA ISOLATES science.uts.edu.au
Validated against 10 clinical isolates science.uts.edu.au
Natalia – Natalia – uterus cells – Natalia – Natalia – uterus cells – day 5 uterus cells – uterus cells – day 7 day 11 day 1 Not toxic against Koala cells Works on Koala Chlamydia isolates grown in Koala cells science.uts.edu.au
JO146 OR DERIVATIVES AS A KOALA THERAPY??? Yes 3-5 year plan or faster science.uts.edu.au
OVERALL PORTFOLIO Intracellular pathogen cultures Antibiotic susceptibility testing Primary tissue work Immune responses Diagnostics Womens health; infertility and pelvic inflammatory disease http://www.uts.edu.au/staff/wilhelmina.huston science.uts.edu.au
Summary : Drug development for the Koala Chlamydial diseases A national icon under major threat An urgent priority A challenging scenario for drug discovery Wilhelmina.Huston@uts.edu.au Core capabilities for research: Chlamydia culture Biochemistry Toxicity Primary Koala tissue work science.uts.edu.au

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