DR. PARTHA BASU HEAD, DEPARTMENT OF GYNECOLOGIC ONCOLOGY - - PowerPoint PPT Presentation

• DR. PARTHA BASU

HEAD, DEPARTMENT OF GYNECOLOGIC ONCOLOGY CHITTARANJAN NATIONAL CANCER INSTITUTE, KOLKATA, INDIA

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Background

 VIA is affordable & feasible test for low &

medium resource countries

 High rate of false positive tests can offset the

cost saving

 Triaging options like magnification, cytology

• etc. have not been successful

 HPV DNA detection Hybrid Capture 2 is highly

sensitive & reasonably specific

 Low cost version (CareHPV) is available

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Objectives & Methods

 The study aims to evaluate role of

HC2 in triaging the VIA +ve women

 Total 21764 women aged 30-60 yrs (mean

38.4 + 6.1 yrs) screened by HC2 & VIA

 All VIA +ve women had colposcopy  Punch biopsies obtained if colpo abnormal

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Results

NORMAL BX/COLPO HPV/ ATYPIA/ CIN1 CIN2 CIN3 INV CA TOTA L VIA +ve; HC2 -ve 756 728 38 8 1530 VIA +ve; HC2 +ve 48 54 11 35 18 166 TOTAL 804 782 49 43 18 1696

• PPV OF VIA FOR CIN3+: 3.6%
• PPV OF VIA & HC2 FOR CIN3+: 31.9%

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CONCLUSIONS

 Triaging with HC2 reduces referral

from 7.8% to 0.8%

 Sensitivity to detect CIN3+: 86.9%  Specificity to detect CIN3+: 93.1%  Sample for HC2 can be obtained

immediately after VIA