Double stranded helicates metal binding domain bridge - - PowerPoint PPT Presentation

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double stranded helicates
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Double stranded helicates metal binding domain bridge - - PowerPoint PPT Presentation

Apr 04, 2023 170 likes •582 views

Double stranded helicates metal binding domain bridge substitution pattern Double helicates Triple stranded helicates - Ni(II) : octahedral geometry - one ligand can not wrap around one Ni(II) cation : trimerization - other metals: Co(II),

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binding domain bridge metal

Double stranded helicates

substitution pattern

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Double helicates

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  • Ni(II) : octahedral geometry
  • one ligand can not wrap around one Ni(II) cation : trimerization
  • other metals: Co(II), Fe(II), lanthanides

Triple stranded helicates

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Double and Triple Helicates: an example of Selective-Recognition

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Cyclic Helicates

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2X2 Cu(I) grid

Molecular Grids

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Reaction year A B h/c catalyst Glaser 1869 RC≡CH sp RC≡CH sp homo Cu Ullmann 1901 Ar-X sp² Ar-X sp² homo Cu Sonogashira 1975 RC≡CH sp R-X sp³ sp² cross Pd and Cu Negishi 1977 R-Zn-X sp³, sp², sp R-X sp³ sp² cross Pd or Ni Stille 1978 R-SnR3 sp³, sp², sp R-X sp³ sp² cross Pd Suzuki 1979 R-B(OR)2 sp² R-X sp³ sp² cross Pd Hiyama 1988 R-SiR3 sp² R-X sp³ sp² cross Pd Buchwald- Hartwig 1994 R2N-R SnR3 sp R-X sp² cross Pd

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1H-NMR

ESI-MS

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Catenani

1mM 50mM

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catione paraquat Bis-parafenilene-[34]-crown-10

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acilazione 20%

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Hydrophobic effect

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Hydrophobic effect

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Halogen bond templating