DEEP-LEARNING APPROACHES TO VALIDATE FORMAL MODELS OF BIOLOGICAL - - PowerPoint PPT Presentation

DEEP-LEARNING APPROACHES TO VALIDATE FORMAL MODELS OF BIOLOGICAL SYSTEMS

Mahdi Behroozikhah, Dhranidar Dang, Debashis Sahoo

Boolean Lab

11 0 1 0 1 0 1 1 0 1111 0 0 0 0 11 0 0 0 1 0 0 0 0 0 0 11 0 0 0 0 0 0 0 1 1111 0 0 0 0 1 0 0 1 0 111 1 0 1 0 0 111 0 0 0 111 0 0 1111 0 0 0 1

Motivation

■ It It is h hard t to c create a a f formal m model o

• f

f biological s systems b because t the w working principles a are o

• ften unk

unkno nown ■ Availability of high-throughput sequencing, generated massive d data in the context of biological systems ■ We developed a computational framework where we can start to build abstract formal model of a biological system

Overview

■ Gathered and analyzed hundreds studies ■ Introduced Boolean Model based on gene expression ■ Validated in colon tissue using deep learning

Thank You