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Coronel Instituut, Academisch Medisch Centrum Amsterdam
Creating a bibliographic reference base for new and emerging - - PowerPoint PPT Presentation
Creating a bibliographic reference base for new and emerging - - PowerPoint PPT Presentation
Creating a bibliographic reference base for new and emerging occupational health risks 21 October 2016 Modernet meeting Occupational and environmental diseases; from nano-problem to big data Annet Lenderink Coronel Instituut, Academisch
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New and emerging occupational health risks – finding the unknowns Triangular combinations of health problems, exposure and work setting, in which each of the three components can be new
New diseases are rare, so more often
- Already known diseases
caused by a new or changed way of exposure, or
- Already known exposure in
new work settings
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- Spontaneous reporting of possible new
combinations of health problems, exposure and work setting by occupational physicians, general practitioners and medical specialists
- Reporting by workers
- Active surveillance of health problems in work
settings
- Periodic screening of scientific literature
- Data mining in existing databases
- Combine data from existing databases
- Secondary analyses of patient data in existing
databases
Finding the unknowns: Signal detection - Possible approaches
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Current situation
- Information on new occupational
health risks is difficult to find
- Information is scattered
- References are not easy found
So where to turn to, if you see something in your daily practice that you never saw before
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Using an assessment in five steps:
- Which health problems occur and which
disease can be diagnosed?
- Is there evidence in the scientific
literature substantiating a relation between health problem and suspected exposure?
- Is the exposure relevant?
- Are other explanations possible?
- Final consideration using the Bradford Hill
criteria to assess causality
Evaluation:
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Has someone described it before? What if there were a quick reference database? New and Emerging Risks DataBase: NERDB?
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- Simple
- Adjustable
- Online access but not public
- Accessible after permission
- Connect to (pdf)-files
- Search function available
- No limits to the number of
records
- Cheap
NERDB? Requirements:
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https://www.obvibase.com/#table/ dFxelpBva19s/*
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Each column can be adjusted and edited Literature files can either be added by storing them in a shared Dropbox file
- r through a
URL
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NERDB: what do we need more?
- More records from different sources
- More participating experts
- Comments on existing records
- Adding literature to existing records
- ….
- ….
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