CORUS Co-receptor usage as a marker for specific HIV diagnostics - - PowerPoint PPT Presentation

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CORUS Co-receptor usage as a marker for specific HIV diagnostics - - PowerPoint PPT Presentation

Oct 03, 2023 427 likes •566 views

Co-receptor diagnosis the clinical perspective CORUS Co-receptor usage as a marker for specific HIV diagnostics with high sensitivity CXCR4 CORUS CORUS CORUS MARAVIROC Genotypic assay Moyle 2005 JID 191;866-72 TROFILE TROFILE

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SLIDE 1

CORUS

Co-receptor usage as a marker for specific HIV diagnostics with high sensitivity Co-receptor diagnosis – the clinical perspective

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SLIDE 2

CORUS

CXCR4

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SLIDE 3

CORUS

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SLIDE 4

CORUS

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SLIDE 5

MARAVIROC

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SLIDE 6

Genotypic assay

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SLIDE 7

TROFILE

Moyle 2005 JID 191;866-72

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SLIDE 8

TROFILE

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SLIDE 9

TROFILE

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SLIDE 10

Trofile - drawbacks

  • No detection of minority variant populations
  • Testing only in California or France
  • Labor intensive and expensive
  • Time consuming
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SLIDE 11

CORUS – research goals

Strengths of a new assay should include:

  • Fast and easy performance
  • Applicability in vitro
  • Suitability for routine diagnostics

Development of diagnostic assay for selective detection of X4-tropic minorities in HIV-1-infection

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SLIDE 12

CORUS - Subprojects

  • Univ. Cologne
  • Univ. Düsseldorf

HZI GSH

  • Univ. Duisburg-Essen

SIEMENS DIAGNOSTICS